About Enhancer
| Enhancer ID: | E_04566 |
| Species: | Homo sapiens |
| Position : | chr11:5270500-5271500   |
| Year: | 2025 |
| Title: | Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38760567 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay; Endogenous enhancer perturbation; Disease-variant functional analysis |
| High Throughput Method: | RNA-seq; pooled CRISPRi screen; CRISPR genetic screen |
| Low Throughput Method: | CRISPRi, qRT-PCR; CRISPRi |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_04387 | chr11:5271421-5273421 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer