About Enhancer
| Enhancer ID: | E_04572 |
| Species: | Homo sapiens |
| Position : | chr8:128747315-128748315   |
| Year: | 2011 |
| Title: | Multiple Wnt/?-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 21533051 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | TCF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF4 | AndrogenReceptor | netpath | 167 |
| TCF4 | CDO in myogenesis | reactome | 29 |
| TCF4 | Coregulation of Androgen receptor activity | pid | 61 |
| TCF4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF4 | ID | netpath | 38 |
| TCF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF4 | TGF_beta_Receptor | netpath | 220 |
| TCF4 | Wnt | netpath | 118 |
| TCF4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer