About Enhancer
| Enhancer ID: | E_04582 |
| Species: | Homo sapiens |
| Position : | chr2:16000000-16002000   |
| Year: | 2024 |
| Title: | Super-enhancer MYCNOS-SE promotes chemoresistance in small cell lung cancer by recruiting transcription factors CTCF and KLF15. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | small cell lung carcinoma |
| PMID: | 39511411 |
| MONDO: | MONDO:0008433 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | H446 cells |
| CVCL ID: | CVCL_0049 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Super-enhancer activity assay |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | Luciferase reporter assay; RT-RT-qPCR |
About Target Gene
| Target gene : | MYCNOS |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer