About Enhancer
| Enhancer ID: | E_04610 |
| Species: | Homo sapiens |
| Position : | chr6:135194929-135196024   |
| Year: | 2026 |
| Title: | CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 41759529 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | PDX#2263 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer essentiality screen; Functional cis-regulatory-element perturbation assay |
| High Throughput Method: | Pooled CRISPRi dropout screen; in vivo CRISPR screen; ATAC-seq; single-cell ATAC/RNA profiling; Perturb-seq |
| Low Throughput Method: | Targeted MYB cis-regulatory-element CRISPRi; RT-qPCR; proliferation assay; flow cytometry; in vivo competition validation |
About Target Gene
| Target gene : | MYB |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer