About Enhancer
| Enhancer ID: | E_04616 |
| Species: | Homo sapiens |
| Position : | chr21:43770915-43772915   |
| Year: | 2013 |
| Title: | Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast cancer |
| PMID: | 23675462 |
| MONDO: | MONDO:0007254 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer chromatin-state assay; Enhancer occupancy assay; Transcriptional regulation assay |
| Low Throughput Method: | RPS6KA5/MSK1 ChIP-qPCR; RPS6KA4/MSK2 ChIP-qPCR; H3S10ph ChIP-qPCR; 14-3-3 ChIP-qPCR; SMARCA4/BRG1 ChIP-qPCR; RNA polymerase II ChIP-qPCR; RT-qPCR; siRNA knockdown; TPA stimulation |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04633 | chr21:43770915-43772915 | breast | NA | NA |
| E_04634 | chr21:43770915-43772915 | breast | NA | NA |
| E_03643 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03644 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03645 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03640 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03641 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03642 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
Expression of Target Genes for the Enhancer