About Enhancer
| Enhancer ID: | E_04628 |
| Species: | Mus musculus |
| Position : | chr12:113220000-113233375   |
| Year: | 2018 |
| Title: | 3'Igh enhancers hs3b/hs4 are dispensable for Myc deregulation in mouse plasmacytomas with T(12;15) translocations. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | plasmacytoma |
| PMID: | 30349647 |
| MONDO: | MONDO:0005615 |
| Tissue: | plasma-cell tumor / hematopoietic tumor context |
| Cell Source: | established T(12 |
| Cell Type: | plasma cell |
| Cell Ontology ID: | CL:0000786 |
| Experiment Type: | Genetic enhancer deletion; tumorigenesis/translocation analysis; Myc-expression assessment |
| High Throughput Method: | RNA-seq/transcriptome profiling |
| Low Throughput Method: | hs3b/hs4 germline deletion; tumor induction; translocation breakpoint analysis; qRT-PCR; proliferation/cell-death assays |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04615 | chr12:113220000-113233375 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04629 | chr12:113220000-113233375 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04631 | chr12:113220000-113255414 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_04632 | chr12:113220000-113255414 | plasma-cell tumor / hematopoietic tumor context | plasma cell | plasmacytoma |
| E_03826 | chr12:113228270-113228366 | spleen | B cell | NA |
| E_03827 | chr12:113232344-113232426 | spleen | B cell | NA |
Expression of Target Genes for the Enhancer