About Enhancer
| Enhancer ID: | E_04634 |
| Species: | Homo sapiens |
| Position : | chr21:43770915-43772915   |
| Year: | 2013 |
| Title: | Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 23675462 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | RPS6KA5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RPS6KA5 | CD209 (DC-SIGN) signaling | reactome | 21 |
| RPS6KA5 | CREB phosphorylation | reactome | 7 |
| RPS6KA5 | EGFR1 | netpath | 475 |
| RPS6KA5 | ErbB1 downstream signaling | pid | 105 |
| RPS6KA5 | ERK/MAPK targets | reactome | 17 |
| RPS6KA5 | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | panther | 29 |
| RPS6KA5 | LPA4-mediated signaling events | pid | 16 |
| RPS6KA5 | NCAM signaling for neurite out-growth | reactome | 22 |
| RPS6KA5 | p38 MAPK pathway | panther | 31 |
| RPS6KA5 | PDGF signaling pathway | panther | 113 |
| RPS6KA5 | Recycling pathway of L1 | reactome | 27 |
| RPS6KA5 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| RPS6KA5 | TCR | netpath | 261 |
| RPS6KA5 | TGF_beta_Receptor | netpath | 220 |
| RPS6KA5 | TNFalpha | netpath | 274 |
| RPS6KA5 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| RPS6KA5 | MAPK signaling pathway | kegg | 264 |
| RPS6KA5 | Neurotrophin signaling pathway | kegg | 126 |
| RPS6KA5 | Hs_Interferon_type_I_signaling_pathways_WP585_85198 | wikipathways | 35 |
| RPS6KA5 | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| RPS6KA5 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| RPS6KA5 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| RPS6KA5 | Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 | wikipathways | 34 |
| RPS6KA5 | Hs_Bladder_Cancer_WP2828_89143 | wikipathways | 17 |
| RPS6KA5 | Hs_ERK_Pathway_in_Huntington's_Disease_WP3853_89748 | wikipathways | 10 |
| RPS6KA5 | Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 | wikipathways | 80 |
| RPS6KA5 | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04616 | chr21:43770915-43772915 | breast | malignant cell | breast cancer |
| E_04633 | chr21:43770915-43772915 | breast | NA | NA |
| E_03643 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03644 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03645 | chr21:43771491-43773491 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03640 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03641 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
| E_03642 | chr21:43772291-43774291 | blood / hematopoietic system | malignant cell | Mixed-Lineage Leukemia 1 |
Expression of Target Genes for the Enhancer