About Enhancer
| Enhancer ID: | E_04648 |
| Species: | Mus musculus |
| Position : | chr14:54227135-54228033   |
| Year: | 2016 |
| Title: | Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26673693 |
| Cell Source: | P5424 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR; Western blot |
About Target Gene
| Target gene : | Dad1 |
About TF
| TF name : | Tcf7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf7 | Angiogenesis | panther | 141 |
| Tcf7 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| Tcf7 | Ca2+ pathway | reactome | 62 |
| Tcf7 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Tcf7 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf7 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Tcf7 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf7 | Repression of WNT target genes | reactome | 14 |
| Tcf7 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Tcf7 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Wnt signaling pathway | kegg | 135 |
| Tcf7 | Adherens junction | kegg | 70 |
| Tcf7 | Melanogenesis | kegg | 100 |
| Tcf7 | Pathways in cancer | kegg | 321 |
| Tcf7 | Colorectal cancer | kegg | 63 |
| Tcf7 | Endometrial cancer | kegg | 52 |
| Tcf7 | Prostate cancer | kegg | 85 |
| Tcf7 | Acute myeloid leukemia | kegg | 53 |
| Tcf7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| Tcf7 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer