About Enhancer
| Enhancer ID: | E_04652 |
| Species: | Homo sapiens |
| Position : | chr3:112045517-112046117   |
| Year: | 2009 |
| Title: | Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon-gamma and tumor necrosis factor-alpha. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Graft Rejection,Autoimmune Diseases,Spontaneous Abortion |
| PMID: | 19386363 |
| Cell Source: | HUVEC |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR; Site-directed mutagenesis |
About Target Gene
| Target gene : | CD200 |
About TF
| TF name : | IRF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| IRF1 | Glucocorticoid receptor regulatory network | pid | 85 |
| IRF1 | IFN-gamma pathway | pid | 43 |
| IRF1 | IL12 signaling mediated by STAT4 | pid | 33 |
| IRF1 | IL6-mediated signaling events | pid | 48 |
| IRF1 | Interferon alpha/beta signaling | reactome | 67 |
| IRF1 | Interferon gamma signaling | reactome | 88 |
| IRF1 | Regulation of Telomerase | pid | 70 |
| IRF1 | TRAF6 mediated IRF7 activation | reactome | 33 |
| IRF1 | Hepatitis C | kegg | 134 |
| IRF1 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04653 | chr3:112045517-112046117 | NA | NA | Graft Rejection,Autoimmune Diseases,Spontaneous Abortion |
| E_04654 | chr3:112045517-112046117 | NA | NA | Graft Rejection,Autoimmune Diseases,Spontaneous Abortion |
| E_04658 | chr3:112045517-112046117 | liver | liver sinusoidal endothelial cell | NA |
Expression of Target Genes for the Enhancer