About Enhancer
| Enhancer ID: | E_04666 |
| Species: | Mus musculus |
| Position : | chr1:133347808-133348049   |
| Year: | 2014 |
| Title: | A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24734888 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | juxtaglomerular cells |
| Cell Type: | kidney granular cell |
| Cell Ontology ID: | CL:0000648 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; In vivo physiological assay; Endogenous enhancer perturbation; In vivo functional validation |
| Low Throughput Method: | BAC transgenesis; distal-enhancer deletion; Ren1-null rescue; Northern blot; RT-qPCR; in situ hybridization; plasma renin activity; angiotensin I assay; blood-pressure measurement; Mouse genetic deletion/knock-in; In vivo phenotyping |
About Target Gene
| Target gene : | Ren1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer