About Enhancer
| Enhancer ID: | E_04700 |
| Species: | Homo sapiens |
| Position : | chr3:184276287-184278287   |
| Year: | 2014 |
| Title: | Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 24707046 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | LS174T and other colorectal carcinoma cell lines |
| Cell Type: | malignant epithelial cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF/chromatin occupancy; chromatin accessibility analysis; pathway-dependent enhancer reactivation; disease-associated enhancer decommissioning |
| Low Throughput Method: | Luciferase reporter assay; ChIP; FAIRE; RT-qPCR; pathway perturbation; tumor-cell phenotyping |
About Target Gene
| Target gene : | EPHB3 |
About TF
| TF name : | ASCL2 |
About Regulatory State
| Regulatory State : | Inactive |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer