About Enhancer
| Enhancer ID: | E_04735 |
| Species: | Homo sapiens |
| Position : | chr10:64737032-64737909   |
| Year: | 2015 |
| Title: | Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Ewing sarcoma |
| PMID: | 26214589 |
| MONDO: | MONDO:0012817 |
| Tissue: | bone tissue |
| Tissue Ontology ID: | UBERON:0002481 |
| Cell Source: | A-673 and additional Ewing sarcoma models |
| Cell Type: | Ewing sarcoma cell |
| Experiment Type: | Enhancer activity; fusion-TF occupancy; susceptibility-variant functional assay |
| High Throughput Method: | EWSR1::FLI1 ChIP-seq; H3K27ac/chromatin-state profiling; germline association data |
| Low Throughput Method: | GGAA-microsatellite reporter; fusion-TF perturbation; EGR2 knockdown; proliferation and xenograft assays |
About Target Gene
| Target gene : | EGR2 |
About TF
| TF name : | EWSR1::FLI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04739 | chr10:64737032-64737909 | NA | NA | Ewing Sarcoma |
Expression of Target Genes for the Enhancer