About Enhancer
| Enhancer ID: | E_04772 |
| Species: | Homo sapiens |
| Position : | chr4:100078375-100078940   |
| Year: | 2010 |
| Title: | Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4) |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20363298 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | H1299 negative-control cell line |
| CVCL ID: | CVCL_0060 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Reporter-based enhancer mapping; TF-binding and site-mutation validation |
| Low Throughput Method: | Luciferase reporter assay; EMSA; antibody supershift; site-directed TF-binding-site mutagenesis; haplotype/variant reporter analysis |
About Target Gene
| Target gene : | ADH4 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer