About Enhancer
| Enhancer ID: | E_04784 |
| Species: | Mus musculus |
| Position : | chr3:51508734-51512187   |
| Year: | 2009 |
| Title: | Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Insulin Deficiency |
| PMID: | 18984737 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | 汕TC-3,INS-1,汐TC1.6,NIH3T3 |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Setd7 |
About TF
| TF name : | Pdx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pdx1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Pdx1 | Regulation of gene expression in beta cells | reactome | 17 |
| Pdx1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| Pdx1 | Type II diabetes mellitus | kegg | 44 |
| Pdx1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer