About Enhancer
| Enhancer ID: | E_04797 |
| Species: | Homo sapiens |
| Position : | chr1:230294600-230294900   |
| Year: | 2016 |
| Title: | Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26817450 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep-G2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | GWAS-linked HDL-C regulatory variant; allele-specific enhancer activity and TF binding |
| High Throughput Method: | GWAS; ENCODE/ChIP-seq regulatory-data integration |
| Low Throughput Method: | Dual-luciferase/allele-specific reporter; EMSA; ChIP/ChIP-qPCR; RT-qPCR |
About Target Gene
| Target gene : | GALNT2 |
About TF
| TF name : | NR3C2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR3C2 | Eplerenone Action Pathway | smpdb | 33 |
| NR3C2 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR3C2 | Spironolactone Action Pathway | smpdb | 33 |
| NR3C2 | Transcription/Translation | smpdb | 13 |
| NR3C2 | Aldosterone-regulated sodium reabsorption | kegg | 42 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04808 | chr1:230293530-230305966 | liver | hepatocyte | NA |
| E_04796 | chr1:230294600-230294900 | liver | malignant cell | NA |
| E_04798 | chr1:230294600-230294900 | liver | malignant cell | NA |
| E_04799 | chr1:230294600-230294900 | liver | malignant cell | NA |
| E_04807 | chr1:230294600-230294900 | liver | malignant cell | NA |
Expression of Target Genes for the Enhancer