About Enhancer
| Enhancer ID: | E_04811 |
| Species: | Mus musculus |
| Position : | chr3:37126710-37127250   |
| Year: | 2000 |
| Title: | The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 11120824 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hepa-1c1c7 |
| CVCL ID: | CVCL_0328 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; TF binding assay; ligand-responsive endogenous target validation; genetic TF-dependence validation |
| Low Throughput Method: | Luciferase reporter assay; EMSA/competition EMSA/supershift; TCDD stimulation; RT-PCR; IL-2 ELISA; Ahr-deficient mouse validation |
About Target Gene
| Target gene : | Il2 |
About TF
| TF name : | Arnt |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Arnt | AndrogenReceptor | netpath | 167 |
| Arnt | HIF-1-alpha transcription factor network | pid | 67 |
| Arnt | HIF-2-alpha transcription factor network | pid | 34 |
| Arnt | Hypoxia response via HIF activation | panther | 16 |
| Arnt | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | pid | 19 |
| Arnt | Notch-mediated HES/HEY network | pid | 48 |
| Arnt | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| Arnt | Pathways in cancer | kegg | 321 |
| Arnt | Renal cell carcinoma | kegg | 65 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer