About Enhancer
| Enhancer ID: | E_04815 |
| Species: | Homo sapiens |
| Position : | chr9:132491985-132492534   |
| Year: | 2012 |
| Title: | Regulation of human microsomal prostaglandin E synthase-1 by IL-1汕 requires a distal enhancer element with a unique role for C/EBP汕. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Lung Cancer |
| PMID: | 22260630 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | HFL-1 |
| Experiment Type: | TF-binding/chromatin assay; Disease-associated enhancer analysis |
| Low Throughput Method: | ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | PTGES |
About TF
| TF name : | EGR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EGR1 | AP-1 transcription factor network | pid | 71 |
| EGR1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| EGR1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| EGR1 | ErbB1 downstream signaling | pid | 105 |
| EGR1 | Glucocorticoid receptor regulatory network | pid | 85 |
| EGR1 | Interferon alpha/beta signaling | reactome | 67 |
| EGR1 | Regulation of Androgen receptor activity | pid | 54 |
| EGR1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| EGR1 | Signaling events mediated by PRL | pid | 23 |
| EGR1 | TCR | netpath | 261 |
| EGR1 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| EGR1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| EGR1 | Prion diseases | kegg | 34 |
| EGR1 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
| EGR1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| EGR1 | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04814 | chr9:132491985-132492534 | lung | NA | Lung Cancer |
Expression of Target Genes for the Enhancer