About Enhancer
| Enhancer ID: | E_04823 |
| Species: | Homo sapiens |
| Position : | chr21:36180372-36181392   |
| Year: | 2016 |
| Title: | Identification and functional analysis of acute myeloid leukemia susceptibility associated single nucleotide polymorphisms at non-protein coding regions of RUNX1. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 26374622 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Disease-variant functional analysis |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA; Luciferase reporter assay |
About Target Gene
| Target gene : | RUNX1 |
About TF
| TF name : | SPI1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SPI1 | C-MYB transcription factor network | pid | 87 |
| SPI1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| SPI1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| SPI1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| SPI1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| SPI1 | Glucocorticoid receptor regulatory network | pid | 85 |
| SPI1 | IL4-mediated signaling events | pid | 66 |
| SPI1 | IL4 | netpath | 75 |
| SPI1 | Interleukin signaling pathway | panther | 86 |
| SPI1 | RANKL | netpath | 84 |
| SPI1 | Regulation of retinoblastoma protein | pid | 67 |
| SPI1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| SPI1 | Pathways in cancer | kegg | 321 |
| SPI1 | Acute myeloid leukemia | kegg | 53 |
| SPI1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04824 | chr21:36180372-36181392 | blood / hematopoietic system | malignant cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer