About Enhancer
| Enhancer ID: | E_04862 |
| Species: | Mus musculus |
| Position : | chr16:95721049-95979933   |
| Year: | 2026 |
| Title: | The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 41253710 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | cardiac endothelial cells |
| Cell Type: | endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | Super-enhancer functional perturbation assay; EndoMT assay; In vivo ageing phenotype assay |
| High Throughput Method: | snRNA-seq; RNA-seq; ATAC-seq |
| Low Throughput Method: | Ets2 super-enhancer deletion mouse; endothelial-specific Ets2 knockout; qRT-PCR; histology; fibrosis and cardiac-function assays |
About Target Gene
| Target gene : | Ets2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer