About Enhancer
| Enhancer ID: | E_04891 |
| Species: | Homo sapiens |
| Position : | chr2:234665349-234665739   |
| Year: | 2019 |
| Title: | Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30397001 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HepaRG |
| CVCL ID: | CVCL_9720 |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Nuclear-receptor enhancer assay; coactivator perturbation; TF/cofactor occupancy |
| Low Throughput Method: | Luciferase reporter assay; CCAR1 siRNA; NR1I3/CAR activation; ChIP; qRT-PCR; Western blot |
About Target Gene
| Target gene : | UGT1A1 |
About TF
| TF name : | NR1I3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR1I3 | Glucocorticoid receptor regulatory network | pid | 85 |
| NR1I3 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR1I3 | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04870 | chr2:234665349-234665739 | liver | hepatocyte | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer