About Enhancer
| Enhancer ID: | E_04921 |
| Species: | Homo sapiens |
| Position : | chr6:161119825-161121825   |
| Year: | 2013 |
| Title: | Estrogen modulates plasminogen promoter activity. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 23872150 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | hepatic reporter cell models |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Estrogen-responsive enhancer/promoter regulatory assay; Enhancer activity assay |
| Low Throughput Method: | Luciferase reporter assay; ERE mutagenesis; estrogen stimulation; Reporter assay |
About Target Gene
| Target gene : | PLG |
About TF
| TF name : | ESR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ESR1 | AndrogenReceptor | netpath | 167 |
| ESR1 | AP-1 transcription factor network | pid | 71 |
| ESR1 | ATF-2 transcription factor network | pid | 59 |
| ESR1 | Cellular roles of Anthrax toxin | pid | 25 |
| ESR1 | FOXA1 transcription factor network | pid | 45 |
| ESR1 | FOXM1 transcription factor network | pid | 43 |
| ESR1 | Leptin | netpath | 98 |
| ESR1 | LKB1 signaling events | pid | 43 |
| ESR1 | Nuclear Receptor transcription pathway | reactome | 51 |
| ESR1 | Nuclear signaling by ERBB4 | reactome | 25 |
| ESR1 | Plasma membrane estrogen receptor signaling | pid | 42 |
| ESR1 | Prolactin | netpath | 105 |
| ESR1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| ESR1 | Regulation of Telomerase | pid | 70 |
| ESR1 | Signaling events mediated by HDAC Class II | pid | 58 |
| ESR1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| ESR1 | Tamoxifen Action Pathway | smpdb | 10 |
| ESR1 | Tamoxifen Metabolism Pathway | smpdb | 10 |
| ESR1 | TGF_beta_Receptor | netpath | 220 |
| ESR1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| ESR1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| ESR1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| ESR1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| ESR1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| ESR1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer