About Enhancer
| Enhancer ID: | E_04931 |
| Species: | Homo sapiens |
| Position : | chr2:191800000-191801000   |
| Year: | 2013 |
| Title: | REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cutaneous melanoma |
| PMID: | 23598529 |
| MONDO: | MONDO:0005012 |
| Tissue: | zone of skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | Melanoma cells |
| Cell Type: | melanoma cell |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq; microarray |
| Low Throughput Method: | Luciferase reporter assay; ChIP-qPCR; RT-qPCR; Western blot |
About Target Gene
| Target gene : | STAT1 |
About TF
| TF name : | IRF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| IRF1 | Glucocorticoid receptor regulatory network | pid | 85 |
| IRF1 | IFN-gamma pathway | pid | 43 |
| IRF1 | IL12 signaling mediated by STAT4 | pid | 33 |
| IRF1 | IL6-mediated signaling events | pid | 48 |
| IRF1 | Interferon alpha/beta signaling | reactome | 67 |
| IRF1 | Interferon gamma signaling | reactome | 88 |
| IRF1 | Regulation of Telomerase | pid | 70 |
| IRF1 | TRAF6 mediated IRF7 activation | reactome | 33 |
| IRF1 | Hepatitis C | kegg | 134 |
| IRF1 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer