About Enhancer
| Enhancer ID: | E_04954 |
| Species: | Homo sapiens |
| Position : | chr22:35767789-35768189   |
| Year: | 2013 |
| Title: | The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast cancer |
| PMID: | 22370642 |
| MONDO: | MONDO:0007254 |
| Tissue: | uterine cervix |
| Tissue Ontology ID: | UBERON:0000002 |
| Cell Source: | HeLa |
| CVCL ID: | CVCL_0030 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | TF binding assay; Transcriptional coactivator assay |
| Low Throughput Method: | NFE2L2/NCOA3 transfection; ChIP-PCR; co-immunoprecipitation; FRET; GST pull-down; RT-PCR; Western blot; ChIP |
About Target Gene
| Target gene : | HMOX1 |
About TF
| TF name : | NFE2L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2L2 | Protein processing in endoplasmic reticulum | kegg | 166 |
| NFE2L2 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| NFE2L2 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer