About Enhancer
| Enhancer ID: | E_04967 |
| Species: | Homo sapiens |
| Position : | chr1:101402363-101412724   |
| Year: | 2011 |
| Title: | Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Atherosclerosis |
| PMID: | 21464207 |
| Cell Source: | HUVEC |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | VCAM1 |
About TF
| TF name : | STAT6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| STAT6 | Downstream signal transduction | reactome | 29 |
| STAT6 | EGF receptor signaling pathway | panther | 109 |
| STAT6 | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| STAT6 | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| STAT6 | Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| STAT6 | IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) | inoh | 10 |
| STAT6 | IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) | inoh | 7 |
| STAT6 | IL12-mediated signaling events | pid | 62 |
| STAT6 | IL4-mediated signaling events | pid | 66 |
| STAT6 | IL4 | netpath | 75 |
| STAT6 | IL9 | netpath | 24 |
| STAT6 | Interleukin signaling pathway | panther | 86 |
| STAT6 | JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 97 |
| STAT6 | JAK/STAT signaling pathway | panther | 15 |
| STAT6 | PDGF signaling pathway | panther | 113 |
| STAT6 | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| STAT6 | Signaling events mediated by TCPTP | pid | 40 |
| STAT6 | TSLP | netpath | 24 |
| STAT6 | Jak-STAT signaling pathway | kegg | 149 |
| STAT6 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| STAT6 | Hs_Cytokines_and_Inflammatory_Response_WP530_79331 | wikipathways | 21 |
| STAT6 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
| STAT6 | Hs_G1_to_S_cell_cycle_control_WP45_80001 | wikipathways | 8 |
| STAT6 | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer