About Enhancer
| Enhancer ID: | E_04981 |
| Species: | Mus musculus |
| Position : | chr5:87705429-87705829   |
| Year: | 2011 |
| Title: | Progesterone receptor directly inhibits ζ±-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21527503 |
| Tissue: | mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | HC11 |
| CVCL ID: | CVCL_0288 |
| Cell Type: | epithelial cell of mammary gland |
| Experiment Type: | Enhancer occupancy assay; Chromatin modification assay; Functional hormone-response assay |
| Low Throughput Method: | ChIP-qPCR; prolactin/hydrocortisone/R5020 hormone perturbation; histone-modification ChIP; RT-qPCR; Western blot |
About Target Gene
| Target gene : | Csn2 |
About TF
| TF name : | Nr3c1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nr3c1 | AndrogenReceptor | netpath | 167 |
| Nr3c1 | AP-1 transcription factor network | pid | 71 |
| Nr3c1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Nr3c1 | Cellular roles of Anthrax toxin | pid | 25 |
| Nr3c1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Nr3c1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Nr3c1 | IL2 | netpath | 81 |
| Nr3c1 | Nuclear Receptor transcription pathway | reactome | 51 |
| Nr3c1 | PTK6 Expression | reactome | 5 |
| Nr3c1 | Regulation of Androgen receptor activity | pid | 54 |
| Nr3c1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Nr3c1 | Signaling events mediated by HDAC Class II | pid | 58 |
| Nr3c1 | Neuroactive ligand-receptor interaction | kegg | 272 |
| Nr3c1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Nr3c1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| Nr3c1 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| Nr3c1 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
| Nr3c1 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
Expression of Target Genes for the Enhancer