About Enhancer
| Enhancer ID: | E_04982 |
| Species: | Mus musculus |
| Position : | chr5:87705429-87705829   |
| Year: | 2011 |
| Title: | Progesterone receptor directly inhibits ζ±-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21527503 |
| Tissue: | mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | HC11 |
| CVCL ID: | CVCL_0288 |
| Cell Type: | epithelial cell of mammary gland |
| Experiment Type: | Enhancer occupancy assay; Chromatin modification assay; Functional hormone-response assay |
| Low Throughput Method: | ChIP-qPCR; prolactin/hydrocortisone/R5020 hormone perturbation; histone-modification ChIP; RT-qPCR; Western blot |
About Target Gene
| Target gene : | Csn2 |
About TF
| TF name : | Pgr |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pgr | Cellular roles of Anthrax toxin | pid | 25 |
| Pgr | Nuclear Receptor transcription pathway | reactome | 51 |
| Pgr | Nuclear signaling by ERBB4 | reactome | 25 |
| Pgr | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Pgr | Oocyte meiosis | kegg | 110 |
| Pgr | Progesterone-mediated oocyte maturation | kegg | 84 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
Expression of Target Genes for the Enhancer