About Enhancer
| Enhancer ID: | E_04986 |
| Species: | Homo sapiens |
| Position : | chr3:12311574-12312573   |
| Year: | 2019 |
| Title: | Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31888703 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | HEK293T |
| CVCL ID: | CVCL_0063 |
| Cell Type: | embryonic kidney cell |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| Low Throughput Method: | Luciferase Reporter Assay; EMSA; RT-RT-qPCR; Western blot; Reporter assay |
About Target Gene
| Target gene : | PPARG |
About TF
| TF name : | ATF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ATF4 | Apoptosis signaling pathway | panther | 104 |
| ATF4 | ATF4 activates genes | reactome | 25 |
| ATF4 | ATF6-alpha activates chaperone genes | reactome | 10 |
| ATF4 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| ATF4 | MAPK signaling pathway | kegg | 264 |
| ATF4 | Protein processing in endoplasmic reticulum | kegg | 166 |
| ATF4 | Long-term potentiation | kegg | 67 |
| ATF4 | Neurotrophin signaling pathway | kegg | 126 |
| ATF4 | GnRH signaling pathway | kegg | 98 |
| ATF4 | Prostate cancer | kegg | 85 |
| ATF4 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| ATF4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| ATF4 | Hs_One_Carbon_Metabolism_WP241_89671 | wikipathways | 14 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer