About Enhancer
| Enhancer ID: | E_04987 |
| Species: | Mus musculus |
| Position : | chr7:143459000-143459700   |
| Year: | 2015 |
| Title: | Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26071365 |
| Tissue: | embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | E11.5 primary maxillary arch cells |
| Cell Type: | cranial neural crest-derived mesenchymal cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; developmental regulatory assay |
| High Throughput Method: | LHX6 ChIP-seq; transcriptional profiling |
| Low Throughput Method: | p57Kip2 enh1 luciferase reporter assay; FOX motif analysis; FOXP1 overexpression; FOXD1 overexpression; ChIP-qPCR; immunofluorescence; RNA in situ hybridization; Reporter assay |
About Target Gene
| Target gene : | Cdkn1c |
About TF
| TF name : | Foxp1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02738 | chr7:143459000-143459700 | embryonic mesenchyme / fibroblast model | embryonic fibroblast / cranial neural crest-derived cell | NA |
| E_02794 | chr7:143459000-143459700 | embryo | embryonic fibroblast | NA |
| E_02799 | chr7:143459000-143459700 | embryonic mesenchyme / fibroblast model | embryonic fibroblast / cranial neural crest-derived cell | NA |
| E_02819 | chr7:143459000-143460200 | embryonic craniofacial mesenchyme | embryonic fibroblast | NA |
| E_02924 | chr7:143459000-143459700 | facial mesenchyme | cranial neural crest cell | NA |
| E_02831 | chr7:143459172-143459787 | NA | fibroblast | NA |
Expression of Target Genes for the Enhancer