About Enhancer
| Enhancer ID: | E_05006 |
| Species: | Homo sapiens |
| Position : | chr8:128413174-128414429   |
| Year: | 2012 |
| Title: | Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 22429595 |
| MONDO: | MONDO:0024331 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | heterozygous enhancer models |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Cancer-risk enhancer variant functional characterization; allele-specific TF binding |
| High Throughput Method: | Genotyping / population variant analysis |
| Low Throughput Method: | ChIP; allele-specific binding; enhancer reporter; Wnt-response assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | GFI1B |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04111 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_04112 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_04113 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_03718 | chr8:128412536-128414073 | colon | malignant cell | colorectal carcinoma |
| E_04062 | chr8:128413136-128414674 | prostate gland | epithelial cell | prostate cancer |
| E_03347 | chr8:128413174-128414429 | colon | epithelial cell | colorectal cancer |
| E_05003 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05004 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05005 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05007 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05008 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer