About Enhancer
| Enhancer ID: | E_05032 |
| Species: | Homo sapiens |
| Position : | chr21:40003867-40015913   |
| Year: | 2018 |
| Title: | Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Leukemia |
| PMID: | 29765516 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | HEL |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | ERG |
About TF
| TF name : | KDM1A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KDM1A | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| KDM1A | AndrogenReceptor | netpath | 167 |
| KDM1A | Coregulation of Androgen receptor activity | pid | 61 |
| KDM1A | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| KDM1A | HDACs deacetylate histones | reactome | 94 |
| KDM1A | HDMs demethylate histones | reactome | 49 |
| KDM1A | Notch-mediated HES/HEY network | pid | 48 |
| KDM1A | Notch signaling pathway | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer