About Enhancer
| Enhancer ID: | E_05111 |
| Species: | Homo sapiens |
| Position : | chr11:5248027-5248047   |
| Year: | 1999 |
| Title: | The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 10595394 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562,HEL |
| CVCL ID: | CVCL_0004 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; EMSA/gel-shift assay |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | SATB1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SATB1 | Apoptotic cleavage of cellular proteins | reactome | 18 |
| SATB1 | Caspase Cascade in Apoptosis | pid | 57 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_03627 | chr11:5241525-5251525 | bone marrow | erythroblast | NA |
| E_05110 | chr11:5248027-5248047 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer