Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_05205
Species: Mus musculus
Position : chr14:67741735-67744661
Year: 2012
Title: Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  22761896
Tissue: gonad
Tissue Ontology ID: UBERON:0000991
Cell Source: GT1-7
Experiment Type: Enhancer activity assay; TF-binding/chromatin assay
Low Throughput Method: Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; Western blot; Histology/immunostaining
About Target Gene
Target gene : Gnrh1
About TF
TF name : Otx2
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 3 found
Enhancer ID Position Tissue Cell Disease
E_04536 chr14:67742375-67743103 gonad NA NA
E_04537 chr14:67742375-67743103 gonad NA NA
E_03671 chr14:67743318-67743610 NA GnRH neuron NA
Expression of Target Genes for the Enhancer