Gene Overview
Target Gene: C8orf46
NCBI Official Symbol: VXN
Entrez ID: 254778
Ensembl ID: ENSG00000169085
Gene Full Name: vexin
Strand: +
Gene Locus: 8q13.1
External Links:

C8orf46 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate C8orf46   
T(co)Fs that Repress C8orf46
The Intensity of the Gene Regulated by T(co)Fs:
C8orf46-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
C8orf46 ESR1 siRNA Mammary_gland MCF7 0.57825 -0.79022 2.25503e-06 0.00117 DataSet_01_111
C8orf46 ID1 siRNA Lung A549 2.17177 1.11887 0.16005 0.39502 DataSet_01_117
C8orf46 ZIC2 siRNA Pancreas PANC1 3.22506 1.68933 - - DataSet_01_121
C8orf46 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.6948 0.76111 0.14049 0.96624 DataSet_01_137
C8orf46 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.56435 0.64556 0.28727 0.99993 DataSet_01_138
C8orf46 HSF1 shRNA Skin A375 1.76874 0.82272 0.00163 0.01794 DataSet_01_155
C8orf46 ELK1 siRNA Peripheral_blood CD4+ T cells 0.56423 -0.82565 0.24549 0.45645 DataSet_01_162
C8orf46 GATA3 siRNA Peripheral_blood CD4+ T cells 2.31122 1.20865 0.01211 0.20216 DataSet_01_163
C8orf46 JUN siRNA Peripheral_blood CD4+ T cells 0.46005 -1.12012 0.09682 0.28499 DataSet_01_164
C8orf46 MAF siRNA Peripheral_blood CD4+ T cells 0.61601 -0.69896 0.36329 0.71779 DataSet_01_165
C8orf46 HOXB7 siRNA Pancreas MIA PaCa-2 0.56819 -0.81555 0.01005 0.55356 DataSet_01_169
C8orf46 HOXB7 siRNA Pancreas Capan-1 0.35024 -1.5136 0.00084 0.27898 DataSet_01_170
C8orf46 TP53 siRNA Lung SAECs 1.95322 0.96585 0.07659 0.45658 DataSet_01_175
C8orf46 TCF4 siRNA Autonomic_ganglia SH-SY5Y 0.62292 -0.68287 0.06927 0.21018 DataSet_01_185
C8orf46 CREB1 shRNA Parotid_gland H3118 MEC 3.54107 1.82419 0.01273 0.19913 DataSet_01_194
C8orf46 TP63 siRNA Immortalized_keratinocyte HaCaT RG 3.97614 1.99137 - - DataSet_01_197
C8orf46 TP63 siRNA Head_and_neck SCC-1 1.54977 0.63206 - - DataSet_01_199
C8orf46 TP63 siRNA Head_and_neck SCC-6 1.89443 0.92176 - - DataSet_01_202
C8orf46 HIC1 shRNA Mammary_gland HBL100 2.98601 1.57822 - - DataSet_01_205
C8orf46 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 6.82359 2.77053 - - DataSet_01_210
C8orf46 REST siRNA Prostate LNCaP 0.41871 -1.25598 0.02207 0.2066 DataSet_01_211
C8orf46 KLF2 shRNA Bone_marrow RPMI8226 0.56248 -0.83012 0.22416 0.79266 DataSet_01_226
C8orf46 FOXP1 siRNA Prostate LNCaP 1.79154 0.8412 0.01888 0.30519 DataSet_01_234
C8orf46 TWIST1 shRNA Stomach CAF32 0.64122 -0.64111 0.00961 0.05096 DataSet_01_253
C8orf46 ZIC5 siRNA Skin A375 0.64087 -0.6419 - - DataSet_01_284
C8orf46 ZIC5 siRNA Skin SK-MEL-28 0.50029 -0.99917 - - DataSet_01_285
C8orf46 POSTN shRNA Brain GSC272 5.39715 2.4322 0.07975 0.54319 DataSet_01_293
C8orf46 TFAP4 siRNA Brain BE(2)-C 0.2558 -1.9669 0.42181 0.51625 DataSet_01_295
C8orf46 PTEN shRNA Skin A431 3.39263 1.7624 0.03725 0.15806 DataSet_01_301
C8orf46 PTEN shRNA Mammary_gland SKBR3 2.01531 1.011 0.07437 0.5942 DataSet_01_303
C8orf46 NR2E1 shRNA Neuroepithelium PBT003 0.52216 -0.93745 0.06078 0.4874 DataSet_01_306
C8orf46 SOX9 siRNA Prostate VCaP 1.55749 0.63922 0.34766 0.93949 DataSet_01_308
C8orf46 SOX9 siRNA Prostate VCaP 1.55749 0.63922 0.34766 0.93949 DataSet_01_309
C8orf46 ELK3 shRNA Mammary_gland MDA-MB-231 0.36679 -1.44696 4.59311e-05 0.00035 DataSet_01_318
C8orf46 MYC siRNA Colon HCT116 2.96954 1.57024 0.19573 0.25611 DataSet_01_324
C8orf46 CDX2 siRNA Colon COLO320 1.7338 0.79394 - - DataSet_01_357
C8orf46 PAX3 shRNA Soft_tissue Rh30 1.73 0.79077 - - DataSet_01_359
C8orf46 RBM17 shRNA Liver HepG2 8.5 3.08746 0.44196 0.6847 DataSet_02_100
C8orf46 RBFOX2 shRNA Liver HepG2 13 3.70044 0.41276 0.75902 DataSet_02_101
C8orf46 SAFB2 shRNA Liver HepG2 0.26667 -1.90689 0.11984 0.19785 DataSet_02_102
C8orf46 U2AF2 shRNA Liver HepG2 0.06 -4.05889 0.2745 0.42311 DataSet_02_105
C8orf46 TAF15 shRNA Liver HepG2 33.1429 5.05063 0.27659 0.34976 DataSet_02_106
C8orf46 SSB shRNA Liver HepG2 3.78049 1.91857 0.25912 0.32937 DataSet_02_107
C8orf46 ZNF622 shRNA Liver HepG2 0.41615 -1.26483 0.25241 0.32689 DataSet_02_108
C8orf46 HNRNPUL1 shRNA Liver HepG2 0.13333 -2.90689 0.02637 0.07019 DataSet_02_109
C8orf46 GTF2F1 shRNA Liver HepG2 0.03333 -4.90689 0.05359 0.32299 DataSet_02_110
C8orf46 RBM39 shRNA Liver HepG2 70.5 6.13955 0.09699 0.3249 DataSet_02_111
C8orf46 XRCC5 shRNA Liver HepG2 0.18667 -2.42146 0.3067 0.50793 DataSet_02_114
C8orf46 SUB1 shRNA Liver HepG2 0.05333 -4.22882 0.07507 0.23627 DataSet_02_117
C8orf46 CEBPZ shRNA Liver HepG2 10.3158 3.36678 0.93261 1 DataSet_02_118
C8orf46 RBM25 shRNA Liver HepG2 3.42857 1.77761 0.03457 0.08217 DataSet_02_119
C8orf46 PTBP1 shRNA Liver HepG2 5.42857 2.44057 0.54905 0.59809 DataSet_02_120
C8orf46 EWSR1 shRNA Liver HepG2 3.16667 1.66297 0.02364 0.08829 DataSet_02_122
C8orf46 PCBP2 shRNA Liver HepG2 0.48 -1.05889 0.67043 0.79093 DataSet_02_123
C8orf46 HNRNPLL shRNA Liver HepG2 6.61538 2.72583 0.81933 0.86307 DataSet_02_125
C8orf46 SNRNP70 shRNA Liver HepG2 0.07692 -3.70044 0.04286 0.11088 DataSet_02_126
C8orf46 SRSF3 shRNA Liver HepG2 8.61538 3.10692 0.02702 0.11895 DataSet_02_127
C8orf46 PRPF4 shRNA Liver HepG2 0.44444 -1.16993 0.51653 0.62755 DataSet_02_128
C8orf46 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.05307 0.48869 DataSet_02_146
C8orf46 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.46667 -1.09954 0.30142 0.4487 DataSet_02_147
C8orf46 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_160
C8orf46 ZFX siRNA Prostate C4-2B 2.16667 1.11548 0.31363 0.43066 DataSet_02_172
C8orf46 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.04153 1 DataSet_02_173
C8orf46 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.0113 -6.46761 0.00393 1 DataSet_02_174
C8orf46 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.42857 -1.22239 0.20108 1 DataSet_02_182
C8orf46 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.22034 -2.1822 0.05544 1 DataSet_02_183
C8orf46 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.77778 0.83007 0.17644 1 DataSet_02_190
C8orf46 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.83333 0.87447 0.70921 1 DataSet_02_202
C8orf46 SKI CRISPR Blood HL60 4 2 2.649575e-01 0.615851377 DataSet_03_351
C8orf46 ETV5 knockdown Colon HT29 0.181818 -2.45943 2.048304e-01 0.501288503 DataSet_03_353
C8orf46 CREBBP CRISPR Brain U5-NPC 1.87483 0.90676 0.2411746333 0.7490853 DataSet_03_356
C8orf46 TP53 CRISPR Brain U5-NPC 3.01361 1.59149 5.745060e-03 1.623145e-01 DataSet_03_358
C8orf46 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.502555 -0.992647 6.191815e-01 7.024754e-01 DataSet_03_362
C8orf46 USP22 shRNA Liver PLC_PRF_5 cells 0.284615 -1.81291 1.029365e-02 0.11955411 DataSet_03_368
C8orf46 ZNF213 siRNA Mammary_gland MCF7 0.381159 -1.39153 5.169232e-02 4.399812e-01 DataSet_03_376
C8orf46 EZH2 CRISPR Ovary SKOV3 0.645503 -0.631505 1.113645e-02 0.0809329555 DataSet_03_378
C8orf46 TCF19 CRISPR Oral_squamous CAL27 1.94626 0.960701 2.244589e-03 0.0303893197 DataSet_03_383
C8orf46 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 8.89626 3.1532 0.0970200383 0.8388073 DataSet_03_387
C8orf46 NFKBIA shRNA Bone_marrow U2OS 0.327655 -1.60975 6.653634e-01 0.87475253 DataSet_03_389
C8orf46 KDM5A CRISPR Lung GLC16 3.73385 1.90066 2.053464e-01 0.345717713 DataSet_03_392
C8orf46 JAZF1 siRNA Cervix HeLa Kyoto 2.34478 1.22945 2.144767e-04 0.166322414 DataSet_03_396
C8orf46 EHF shRNA Stomach MKN7 0.114884 -3.12175 - - DataSet_03_402
C8orf46 CDK7 shRNA Bone_marrow D458 1.81395 0.859137 2.239948e-01 0.57864008 DataSet_03_404
C8orf46 MAP3K7 shRNA Prostate LNCaP 0.62963 -0.667425 1.537815e-01 3.758363e-01 DataSet_03_408
C8orf46 E2F6 shRNA Liver HuH7 0.136936 -2.86843 - - DataSet_03_412
C8orf46 FOXK2 shRNA Ovary OVCAR-5 0.279245 -1.84039 5.196219e-02 0.18782348 DataSet_03_419
C8orf46 BRD4 CRISPR Lymph CD8+ T cells 0.583333 -0.777608 - - DataSet_03_420
C8orf46 PRDM1 CRISPR Lymph CD8+ T cells 0.375 -1.41504 - - DataSet_03_421
C8orf46 FOXP3 CRISPR Peripheral_blood Naive Treg 0.318182 -1.65208 1.817082e-01 0.540799641 DataSet_03_427
C8orf46 USP7 shRNA Skin xenograft cells 0.510314 -0.970544 0.27388858 0.4348960 DataSet_03_431
C8orf46 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.285714 -1.80736 - - DataSet_03_432
C8orf46 CBX2 siRNA Mammary_gland MCF7 1.96852 0.977109 1.155149e-01 0.2131322644 DataSet_03_451
C8orf46 EZH2 siRNA Umbilical_vein HUVEC 2.33333 1.22239 2.012543e-01 0.471012770 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate TAF15 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of C8orf46
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines