Gene Overview
Target Gene: ENPP5
NCBI Official Symbol: ENPP5
Entrez ID: 59084
Ensembl ID: ENSG00000112796
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Strand: -
Gene Locus: 6p21.1
External Links:

ENPP5 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate ENPP5   
T(co)Fs that Repress ENPP5
The Intensity of the Gene Regulated by T(co)Fs:
ENPP5-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
ENPP5 AR siRNA Prostate LNCaP 0.60352 -0.728527 0.282169554024282 1 DataSet_03_005
ENPP5 AR siRNA Prostate VCaP 1.69572 0.761901 0.000109981438266313 0.00654405292531716 DataSet_03_007
ENPP5 AR siRNA Prostate LNCaP 5.41129 2.43597 6.80094345397834e-07 5.69209397778622e-06 DataSet_03_011
ENPP5 ARID1A siRNA Mammary_gland MDA-MB-157 1.62913 0.704104 - - DataSet_03_014
ENPP5 CASP8AP2 siRNA Bone_marrow U2OS 1.51368 0.598063 0.0316591010283879 0.190839026859566 DataSet_03_031
ENPP5 CTNNB1 siRNA Mammary_gland MCF7 1.57481 0.65518 0.0799333148520448 0.999436862066063 DataSet_03_058
ENPP5 CTNNB1 siRNA Prostate LNCaP 0.642342 -0.638587 0.0817756966340842 0.563863250781941 DataSet_03_059
ENPP5 E2F1 siRNA Mammary_gland MCF7 1.54423 0.626887 0.0908658819279964 0.999927373439084 DataSet_03_061
ENPP5 EP300 siRNA Prostate LNCaP 0.433238 -1.20677 0.0294904450265646 0.0946151777935615 DataSet_03_065
ENPP5 FOXA1 siRNA Mammary_gland MCF7 2.04243 1.03029 9.62051152209853e-13 1.2245353558828e-10 DataSet_03_081
ENPP5 FOXA1 siRNA Mammary_gland MCF7 2.04243 1.03029 9.62051152209853e-13 1.2245353558828e-10 DataSet_03_082
ENPP5 FOXA1 siRNA Prostate LNCaP 0.582402 -0.779913 7.66695017508696e-05 0.00204091919311635 DataSet_03_083
ENPP5 FOXJ2 siRNA Mammary_gland MCF7 0.619157 -0.691622 0.067777922717784 0.999965704179325 DataSet_03_088
ENPP5 GATA4 siRNA Stomach AGS 2.20669 1.14189 0.149942726889084 0.801572775209983 DataSet_03_105
ENPP5 GATA4 siRNA Stomach KatoIII 0.394695 -1.34119 0.130567031778739 0.901745195691908 DataSet_03_106
ENPP5 GATA6 siRNA Stomach AGS 2.63668 1.39872 0.279641543707165 0.755853731461445 DataSet_03_108
ENPP5 HMGA1 siRNA Mammary_gland MDA-MB-231 1.70175 0.76702 5.71694673785503e-05 0.000600973211690537 DataSet_03_124
ENPP5 HTATIP siRNA Prostate LNCaP 3.22774 1.69052 7.76827334602534e-05 0.000333544822106292 DataSet_03_131
ENPP5 HTATIP2 siRNA Prostate LNCaP 5.35998 2.42223 0.000101884370304556 0.000364323367497717 DataSet_03_132
ENPP5 Klf4 siRNA Skin Primary neonatal keratinocytes 1.56656 0.6476 0.00113596196282608 0.0100119073280418 DataSet_03_147
ENPP5 KLF5 siRNA Stomach KatoIII 0.350971 -1.51057 0.236537031995157 0.681715883735441 DataSet_03_150
ENPP5 KLF5 siRNA Stomach YCC3 0.64576 -0.630931 0.301335554670198 0.661536862110824 DataSet_03_151
ENPP5 MEF2D shRNA Liver HuH7 0.468915 -1.0926 - - DataSet_03_162
ENPP5 MITF siRNA Skin MZ7 0.63002 -0.666531 8.77062737299739e-05 0.000807130360951648 DataSet_03_165
ENPP5 MITF siRNA Skin SK-MEL-5 0.552392 -0.856235 0.000223429830101293 0.00103927070215411 DataSet_03_168
ENPP5 MYC siRNA Colon HT29 3.77831 1.91774 - - DataSet_03_177
ENPP5 MYC siRNA Central_nervous_system DAOY M2.1 1.92149 0.942226 2.04548385696998e-06 1.39599599504207e-05 DataSet_03_178
ENPP5 NMI siRNA Mammary_gland MCF7 0.651363 -0.618465 0.0943989381843918 0.70097870287875 DataSet_03_199
ENPP5 PAX3 siRNA Mammary_gland MCF7 0.626577 -0.674437 0.113807007526167 0.919978041032696 DataSet_03_206
ENPP5 PBX1 siRNA Mammary_gland LTED 1.66722 0.737442 0.00200973813677517 0.99990029707784 DataSet_03_208
ENPP5 PBX1 siRNA Mammary_gland MCF7 2.66517 1.41423 2.67138599437462e-08 0.000112468483232205 DataSet_03_209
ENPP5 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.393769 -1.34458 8.31508340664287e-05 0.00113104981891238 DataSet_03_211
ENPP5 SMARCC1 siRNA Prostate LNCaP 1.76015 0.815698 0.0889460552173675 0.912608433632692 DataSet_03_236
ENPP5 SOX11 siRNA Lung_fibroblast NHLF 1.67269 0.742172 0.0174392847697497 0.227915941036645 DataSet_03_238
ENPP5 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 5.27273 2.39855 - - DataSet_03_246
ENPP5 SP1 siRNA Ovary OVSAYO 0.236642 -2.07922 0.000337188335435408 0.0609035642863007 DataSet_03_251
ENPP5 SRF siRNA Prostate LNCaP 0.486358 -1.03991 0.118007401800052 0.363299727890264 DataSet_03_254
ENPP5 STAT3 CRISPR Embryo hESC 0.122731 -3.02643 0.0344888560644431 0.10466944403263 DataSet_03_258
ENPP5 STAT3 siRNA Prostate DU145 0.46455 -1.10609 5.70916766634454e-07 0.00103026688178909 DataSet_03_260
ENPP5 STAT3 siRNA Prostate LNCaP 4.54023 2.18277 0.000687134628401397 0.00288596543928587 DataSet_03_262
ENPP5 STAT6 siRNA Umbilical_vein HUVEC 4 2 0.146726838744721 0.828842516185313 DataSet_03_264
ENPP5 TET2 siRNA Prostate DU145 1.81129 0.85702 - - DataSet_03_271
ENPP5 TFE3 siRNA Kidney UOK257-2 0.631614 -0.662885 - - DataSet_03_275
ENPP5 TP63 siRNA Skin Primary neonatal keratinocytes 6.97656 2.80252 1.38184217501343e-06 0.000823407168564254 DataSet_03_281
ENPP5 ZNF746 siRNA Colon HCT116 1.71 0.774 - - DataSet_03_293
ENPP5 ZNF750 siRNA Skin Primary neonatal keratinocytes 1.58886 0.667996 0.0215196389503301 0.119728386020657 DataSet_03_294
ENPP5 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.736783283801673 0.924023022360579 DataSet_02_75
ENPP5 CNOT3 shRNA Lung A549 0.607623 -0.718751 3.313758e-01 0.8918353 DataSet_03_340
ENPP5 EZH2 knockdown Uterus Ishikawa (ISK) cell 2.24665 1.16778 - - DataSet_03_324
ENPP5 ELF3 CRISPR Bile_duct HBDEC2 0.138124 -2.85597 1.078589e-06 1.213833e-04 DataSet_03_304
ENPP5 ELF3 knockdown Bile_duct HBDEC2 1.8904 0.91869 1.710642e-05 3.939436e-03 DataSet_03_305
ENPP5 HDAC4 siRNA Liver human hepatocytes 0.508762 -0.974937 9.312923e-08 8.492748e-05 DataSet_03_345
ENPP5 HDAC5 siRNA Liver human hepatocytes 2.45839 1.29771 1.733905e-08 1.232328e-05 DataSet_03_346
ENPP5 PBX1 siRNA Mammary_gland MCF7 2.66517 1.41423 3.870394e-08 1.347499e-04 DataSet_03_326
ENPP5 ETV5 knockdown Colon HT29 0.612338 -0.707601 8.800462e-02 0.312939818 DataSet_03_353
ENPP5 PARP1 siRNA Prostate LNCaP 1.83374 0.874786 6.730719e-02 0.301294363 DataSet_03_354
ENPP5 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.380099 -1.39555 5.992076e-01 7.998454e-01 DataSet_03_359
ENPP5 NCOA3 siRNA Mammary_gland MDA-MB-231 0.650465 -0.620456 8.508137e-01 0.9935879 DataSet_03_361
ENPP5 EP300 shRNA Mammary_gland MCF10AT 0.26087 -1.9386 6.196524e-02 0.209707806 DataSet_03_364
ENPP5 TP53 knockout Stomach SNU1 10.8689 3.44213 0.0667774332 0.9301241 DataSet_03_365
ENPP5 ZNF148 shRNA Mammary_gland MDA-MB-231 0.624634 -0.678917 3.297810e-01 0.561456618 DataSet_03_366
ENPP5 USP22 shRNA Liver PLC_PRF_5 cells 3.2 1.67807 5.868547e-02 0.23352968 DataSet_03_368
ENPP5 DNMT3A knockout Embryo_kidney HEK293T 0.438592 -1.18905 - - DataSet_03_369
ENPP5 TPR shRNA Bone_marrow U2OS 1.84251 0.881676 8.904114e-03 1.322645e-01 DataSet_03_370
ENPP5 ZFP36L1 siRNA Urinary_bladder J82 4.5 2.16992 - - DataSet_03_371
ENPP5 E2F1 siRNA Nasopharynx HK1 0.263158 -1.926 1.041022e-02 1.138967e-01 DataSet_03_373
ENPP5 HNRNPU siRNA Colon RKO 0.513575 -0.961352 - - DataSet_03_374
ENPP5 EZH2 CRISPR Ovary SKOV3 0.275362 -1.8606 1.642110e-02 0.1013541159 DataSet_03_378
ENPP5 NFKB2 siRNA Bone_marrow U2OS 1.92481 0.944718 4.166445e-02 0.26904207 DataSet_03_381
ENPP5 NFKBIA shRNA Bone_marrow U2OS 0.664821 -0.588962 9.292498e-01 0.97005070 DataSet_03_389
ENPP5 ILF2 siRNA Stomach SGC-7901 0.125 -3 0.1724160165 0.35128987 DataSet_03_393
ENPP5 ASXL1 CRISPR Embryo iPSC 1.74446 0.802782 0.2716222371 0.8195857 DataSet_03_394
ENPP5 BMI1 shRNA Bile_duct QBC-939 1.77389 0.826916 5.044120e-02 0.1380231119 DataSet_03_395
ENPP5 IKZF2 CRISPR Lymph CAR T Cell 0.25374 -1.97858 5.329057e-01 0.853234148 DataSet_03_397
ENPP5 TLE4 CRISPR Lymph CAR T Cell 2.19253 1.13259 5.609091e-01 0.80663953 DataSet_03_398
ENPP5 RELA CRISPR Brain T30 3.17663 1.6675 0.1279952728 0.8400824 DataSet_03_399
ENPP5 EHF shRNA Stomach MKN7 0.378068 -1.40328 - - DataSet_03_402
ENPP5 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 0.333333 -1.58496 1.186330e-01 0.3387935 DataSet_03_403
ENPP5 STRAP knockout Nerve SK-N-AS 0.397299 -1.3317 - - DataSet_03_409
ENPP5 E2F2 siRNA Prostate LNCaP 0.647493 -0.627063 1.940058e-01 4.383704e-01 DataSet_03_414
ENPP5 ZKSCAN3 CRISPR Colon HCT116 0.618543 -0.693054 2.931192e-02 0.344899922 DataSet_03_415
ENPP5 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.375 -1.41504 4.935071e-01 0.653859225 DataSet_03_418
ENPP5 FOXK2 shRNA Ovary OVCAR-5 0.431035 -1.21413 1.925732e-01 0.43107386 DataSet_03_419
ENPP5 MAEL CRISPR Liver Alexander cells 0.366667 -1.44746 - - DataSet_03_423
ENPP5 FOXP3 CRISPR Peripheral_blood Naive Treg 0.039604 -4.65821 1.082098e-01 0.435332291 DataSet_03_427
ENPP5 USP7 shRNA Skin xenograft cells 0.558935 -0.839247 0.41103438 0.5331553 DataSet_03_431
ENPP5 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.1875 -2.41504 - - DataSet_03_432
ENPP5 POU2AF1 CRISPR Lymph SUDHL4 0.4 -1.32193 2.060978e-01 0.381817833 DataSet_03_435
ENPP5 EP300 knockout Pancreas HPAF-II orthotopic cells 0.366511 -1.44807 2.646758e-03 1.590523e-02 DataSet_03_436
ENPP5 CIC knockout Brain Immortalized Astrocyte Cells 0.5 -1 6.275163e-01 8.691493e-01 DataSet_03_438
ENPP5 HMG20A siRNA Mammary_gland MDA-MB-231 1.92727 0.946561 0.0857963534 0.3057246 DataSet_03_442
ENPP5 PHF14 siRNA Mammary_gland MDA-MB-231 0.6 -0.736966 0.2230907922 0.5994811 DataSet_03_443
ENPP5 CAMTA1 knockout Embryo_kidney HEK293T 2.11111 1.078 3.656248e-02 0.16156855 DataSet_03_448
ENPP5 RELB CRISPR Colon SW480 1.91841 0.939915 1.962212e-02 1.109989e-01 DataSet_03_449
ENPP5 CBX2 siRNA Mammary_gland MDA-MB-231 2.26097 1.17694 2.005830e-02 7.742594e-02 DataSet_03_450
ENPP5 CBX2 siRNA Mammary_gland MCF7 2.47142 1.30534 1.930713e-05 0.0006421313 DataSet_03_451
ENPP5 SMARCA2 shRNA Lung HCC2302 15.7928 3.98119 4.967791e-10 3.257214e-09 DataSet_03_455
ENPP5 SREBF2 siRNA Umbilical_vein HUVEC 0.307945 -1.69925 2.872075e-01 7.233396e-01 DataSet_03_457
ENPP5 ARID1A shRNA Bile_duct MMNK1 0.470567 -1.08753 8.505645e-03 0.089644475 DataSet_03_458
ENPP5 IRF2 shRNA Cord_Blood CD34+ cells 1.64286 0.716207 - - DataSet_03_460
ENPP5 TXNIP shRNA Cord_Blood CD34+ cells 1.95455 0.966833 - - DataSet_03_461
ENPP5 TXNIP shRNA Cord_blood ST3 2 1 1.634072e-01 0.4516083708 DataSet_03_462
ENPP5 SOX9 knockout Liver HuH7 0.115385 -3.11548 3.501616e-03 2.074829e-02 DataSet_03_463
ENPP5 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.1122 1.07874 - - DataSet_03_467
ENPP5 WHSC1 siRNA Prostate PC3 1.54386 0.626542 6.610002e-02 0.23921849 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of ENPP5
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines