Gene Overview
| Target Gene: | Esr2 |
| NCBI Official Symbol: | Esr2 |
| Entrez ID: | 13983 |
| Ensembl ID: | ENSMUSG00000021055 |
| Gene Full Name: | estrogen receptor 2 (beta) |
| Strand: | - |
| Gene Locus: | 12 C3|12 33.52 cM |
| External Links: |
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Esr2 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Esr2
T(co)Fs
that Repress Esr2
The Intensity of the Gene Regulated by T(co)Fs:
Esr2-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Esr2 | Adnp | knockout | Embryo | Whole embryonic body | 2.40141 | 1.26388 | 0.0895936621409833 | 0.459016866671774 | DataSet_11_001 |
| Esr2 | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 0.636505 | -0.651755 | 0.0460084812270938 | 0.376429619350754 | DataSet_11_013 |
| Esr2 | Bcl6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 5.1573 | 2.36662 | 0.00276898875870188 | 0.209198252826441 | DataSet_11_014 |
| Esr2 | Bhlha9 | knockout | Limb | Whole limb bud | 0.625614 | -0.676656 | - | - | DataSet_11_016 |
| Esr2 | Cebpb | knockout | Bone_marrow | Bone marrow-derived macrophages | 1.66055 | 0.73166 | - | - | DataSet_11_021 |
| Esr2 | Elf5 | knockout | Mammary_gland | Mammary gland | 0.40293 | -1.3114 | 0.0662247763691848 | 0.339205584846539 | DataSet_11_035 |
| Esr2 | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 0.658306 | -0.603171 | 0.797766726886208 | 0.991437141842913 | DataSet_11_048 |
| Esr2 | Gata4 | knockout | Intestine | Jejunum | 2.41875 | 1.27426 | 0.0562631913835215 | 0.517267221846463 | DataSet_11_049 |
| Esr2 | Gfi1 | knockout | Cord_Blood | T-cells | 1.98835 | 0.991568 | 0.280894798457215 | 0.673555906037724 | DataSet_11_053 |
| Esr2 | Jarid2 | knockout | Pancreas | Embryonic pancreas | 4.33333 | 2.11548 | 0.0750078553118445 | 0.763308569857167 | DataSet_11_064 |
| Esr2 | Lhx8 | knockout | Gonads | Oocytes | 0.30649 | -1.70609 | 0.210927475810694 | 0.993830266659981 | DataSet_11_069 |
| Esr2 | Lhx8 | knockout | Ovary | Ovary | 0.220799 | -2.17919 | 0.0253912838337624 | 0.0905724908141897 | DataSet_11_070 |
| Esr2 | Nfil3 | knockout | Bone_marrow | Prepro NK cells | 0.648958 | -0.623802 | 0.0774659862486529 | 0.592103803193821 | DataSet_11_090 |
| Esr2 | Nrf1 | knockdown | Liver | Liver | 0.640575 | -0.64256 | 0.288184767419452 | 0.429040681714174 | DataSet_11_096 |
| Esr2 | Otx2 | knockout | Eye | Retina | 0.299684 | -1.73848 | 0.653084399653993 | 0.999923528647439 | DataSet_11_097 |
| Esr2 | Plagl2 | knockout | Intestine | Small intestine | 0.576923 | -0.793549 | 0.348503914105377 | 0.651137177894722 | DataSet_11_104 |
| Esr2 | Prdm2 | shRNA | Muscle | C2C12 | 1.6386 | 0.712469 | 0.0960037567064605 | 0.848034966967439 | DataSet_11_108 |
| Esr2 | Prox1 | knockout | Liver | Liver | 0.441905 | -1.17819 | - | - | DataSet_11_109 |
| Esr2 | Rest | knockout | Brain | Brain | 0.532258 | -0.909802 | 0.033644958847696 | 1 | DataSet_11_113 |
| Esr2 | Runx1 | knockout | Mammary_gland | Luminal epithelial cells | 1.57713 | 0.657298 | 0.977545867881551 | 0.999784944667092 | DataSet_11_117 |
| Esr2 | Sall4 | shRNA | Embryo | ES cells | 2.31818 | 1.21299 | 0.0695675314701779 | 0.936970439704891 | DataSet_11_123 |
| Esr2 | Smad4 | siRNA | Brain | bEnd3 | 0.102523 | -3.28597 | - | - | DataSet_11_127 |
| Esr2 | Smad4 | knockout | Aorta | Aortic arteries | 0.452126 | -1.1452 | 0.209573931062005 | 0.630416489742579 | DataSet_11_128 |
| Esr2 | Sohlh1 | knockout | Ovary | Ovary | 0.558676 | -0.839917 | 1.24404328316163e-07 | 1.2504123085826e-05 | DataSet_11_134 |
| Esr2 | Sohlh2 | knockout | Ovary | Ovary | 0.555629 | -0.847806 | 3.58408494765074e-07 | 1.99410846384079e-05 | DataSet_11_135 |
| Esr2 | Sox11 | knockout | Eye | Retina | 4.92857 | 2.30117 | - | - | DataSet_11_137 |
| Esr2 | Sox11 | knockout | Brain | Cortex | 0.573637 | -0.80179 | - | - | DataSet_11_138 |
| Esr2 | Spdef | knockout | Colon | Colon | 2.58795 | 1.37181 | 0.654797892835965 | 0.997507742354799 | DataSet_11_146 |
| Esr2 | Tet2 | shRNA | Embryo | ES cells | 0.624502 | -0.679222 | - | - | DataSet_11_161 |
| Esr2 | Wt1 | knockout | Oviduct | Oviduct | 1.99987 | 0.999906 | 0.0665925357630546 | 0.832422680672507 | DataSet_11_180 |
| Esr2 | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 0.451602 | -1.14688 | 8.015318e-02 | 0.9999923 | DataSet_11_187 |
| Esr2 | Cpeb1 | siRNA | Neuron | Neuro-2a | 5.66717 | 2.50263 | - | - | DataSet_11_189 |
| Esr2 | Dnmt3a | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 2.73208 | 1.45 | - | - | DataSet_11_215 |
| Esr2 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.573585 | -0.801921 | 3.919494e-01 | 5.677980e-01 | DataSet_11_192 |
| Esr2 | Smarca4 | shRNA | Embryo | ES cells | 0.56397 | -0.82631 | - | - | DataSet_11_224 |
| Esr2 | Smarca4 | shRNA | Embryo | ES cells | 0.56397 | -0.82631 | - | - | DataSet_11_225 |
| Esr2 | Dnmt3a | siRNA | Embryo | iPSC | 0.317837 | -1.65364 | - | - | DataSet_11_241 |
| Esr2 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 4.92593 | 2.3004 | 2.065382e-04 | 0.0102074440 | DataSet_11_245 |
| Esr2 | Fubp1 | shRNA | Brain | brain neural progenitors | 0.282367 | -1.82436 | 0.7401354154 | 1 | DataSet_11_246 |
| Esr2 | Kdm2a | CRISPR | Embryo | ES cells | 0.583333 | -0.777608 | 0.3318357640 | 1.0000000 | DataSet_11_251 |
| Esr2 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 1.92673 | 0.946151 | 2.851839e-01 | 0.483576239 | DataSet_11_252 |
| Esr2 | Mecp2 | knockout | Adipose_tissue | brown adipose tissue | 1.92297 | 0.943334 | 7.709692e-01 | 0.900127007 | DataSet_11_253 |
| Esr2 | Mecp2 | knockout | Adipose_tissue | inguinal adipose tissue | 0.481934 | -1.05309 | 6.789424e-01 | 0.8263567 | DataSet_11_254 |
| Esr2 | Bcl3 | knockout | Bone | Osteoblast | 0.534884 | -0.902703 | 3.411290e-03 | 3.166236e-01 | DataSet_11_263 |
| Esr2 | Ctnnb1 | knockout | Embryo | MGE cells | 0.264244 | -1.92006 | 9.001160e-02 | 0.327275171 | DataSet_11_266 |
| Esr2 | Dux | knockout | Embryo | Embryo | 4.62888 | 2.21066 | 7.148771e-07 | 2.967538e-05 | DataSet_11_269 |
| Esr2 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 2.14074 | 1.09811 | 9.225654e-01 | 1.00000000 | DataSet_11_272 |
| Esr2 | Dux | knockout | Embryo | Embryo | 4.62888 | 2.21066 | 7.148714e-07 | 2.967224e-05 | DataSet_11_273 |
| Esr2 | Ssrp1 | CRISPR | Embryo | ES cells | 2.02564 | 1.01838 | 1.731620e-01 | 0.7914316 | DataSet_11_278 |
| Esr2 | Usp7 | knockout | Embryo | ES cells | 2.34615 | 1.2303 | 8.626267e-02 | 0.5139919 | DataSet_11_279 |
| Esr2 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 0.657534 | -0.604862 | - | - | DataSet_11_285 |
| Esr2 | Usp7 | siRNA | Embryo | ES cells | 2 | 1 | 4.304270e-01 | 0.7164862 | DataSet_11_287 |
| Esr2 | Med19 | knockout | White_adipose_tissue | Gonadal white adipose tissue | 0.103895 | -3.2668 | 1.250425e-01 | 4.573048e-01 | DataSet_11_289 |
| Esr2 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 2 | 1 | 7.377207e-01 | 0.8903623140 | DataSet_11_294 |
| Esr2 | Sirt3 | knockout | Pancreatic_islets | pancreatic beta cell | 2 | 1 | 2.634236e-01 | 7.144686e-01 | DataSet_11_297 |
| Esr2 | Phf8 | knockout | prostate | Prostate | 0.614754 | -0.701919 | 0.3198656030 | 0.5665066 | DataSet_11_298 |
| Esr2 | Hmg20a | siRNA | Hypothalamus | Primary hypothalamic astrocytes | 7 | 2.80735 | 0.0233811902 | 0.2554116 | DataSet_11_300 |
| Esr2 | Arid2 | knockout | Muscle | LSK | 16 | 4 | 8.436184e-04 | 6.309444e-02 | DataSet_11_301 |
| Esr2 | Dnmt1 | knockout | Skin | Keratinocytes | 2.14372 | 1.10011 | 1.689441e-01 | 0.5517910135 | DataSet_11_303 |
| Esr2 | Satb2 | CRISPR | Colon | Colon organoid | 7 | 2.80735 | 2.970684e-01 | 0.6518149 | DataSet_11_304 |
| Esr2 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.3125 | -1.67807 | - | - | DataSet_11_305 |
| Esr2 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 0.294118 | -1.76553 | - | - | DataSet_11_306 |
| Esr2 | Esr1 | knockout | Liver | Liver | 2.44444 | 1.28951 | 6.600325e-02 | 1.0000000 | DataSet_11_307 |
| Esr2 | Cited2 | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 1.8 | 0.847997 | - | - | DataSet_11_308 |
| Esr2 | Satb2 | knockout | Colon | Intestine epithelium | 0.410526 | -1.28445 | 1.543818e-01 | 0.5220268386 | DataSet_11_316 |
| Esr2 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 1.78571 | 0.836501 | 5.568339e-01 | 7.473016e-01 | DataSet_11_319 |
| Esr2 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.296296 | -1.75489 | 6.531776e-01 | 7.811058e-01 | DataSet_11_320 |
| Esr2 | Bud31 | knockout | Testis | Spermatogonial stem cells | 20.1111 | 4.32992 | 1.022623e-01 | 0.8600602 | DataSet_11_321 |
| Esr2 | Prmt1 | siRNA | Adipose_tissue | 3T3-L1 cells | 2.25 | 1.16992 | 3.133904e-01 | 0.9832045 | DataSet_11_325 |
| Esr2 | Snai1 | knockdown | Heart | Heart | 0.324889 | -1.62198 | 2.849800e-01 | 0.49739886 | DataSet_11_326 |
| Esr2 | Ezh2 | knockout | Eye | Retina | 2.83431 | 1.503 | 0.9133253094 | 1.0000000 | DataSet_11_334 |
| Esr2 | Atrx | knockout | Embryo | ES cells | 0.285714 | -1.80736 | - | - | DataSet_11_335 |
| Esr2 | Dnmt3b | siRNA | Heart | embryonic cardiomyocytes | 0.507936 | -0.97728 | 8.208382e-02 | 0.56584847 | DataSet_11_338 |
| Esr2 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.571429 | -0.807355 | 1.603801e-01 | 0.274928271 | DataSet_11_340 |
| Esr2 | Hnrnpk | siRNA | Embryo | ES cells | 0.227555 | -2.13572 | 3.634458e-03 | 0.014095508 | DataSet_11_342 |
| Esr2 | Pcbp1 | shRNA | Thymus | Th1 | 2 | 1 | 9.966274e-03 | 0.08723011 | DataSet_11_343 |
Regulation Region
Expression Atlas of Esr2