Gene Overview
Target Gene: FAM189A2
NCBI Official Symbol: FAM189A2
Entrez ID: 9413
Ensembl ID: ENSG00000135063
Gene Full Name: family with sequence similarity 189 member A2
Strand: +
Gene Locus: 9q21.12
External Links:

FAM189A2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate FAM189A2   
T(co)Fs that Repress FAM189A2
The Intensity of the Gene Regulated by T(co)Fs:
FAM189A2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
FAM189A2 ESR1 siRNA Mammary_gland MCF7 0.63825 -0.64781 0.00034 0.02475 DataSet_01_111
FAM189A2 TCF3 shRNA Mammary_gland MDA-MB468 1.85522 0.89159 4.22318e-05 0.00135 DataSet_01_116
FAM189A2 ID1 siRNA Lung A549 1.59004 0.66906 0.0144 0.15851 DataSet_01_117
FAM189A2 ZIC2 siRNA Pancreas PANC1 1.69773 0.76361 - - DataSet_01_121
FAM189A2 EGR4 siRNA Lung SBC-5 0.61613 -0.6987 0.02337 0.23823 DataSet_01_132
FAM189A2 SF1 siRNA Adrenal_gland H295R/TR 0.5605 -0.8352 1.19692e-05 6e-04 DataSet_01_146
FAM189A2 JUN siRNA Peripheral_blood CD4+ T cells 88.8517 6.47333 0.16397 0.39078 DataSet_01_164
FAM189A2 TP53 siRNA Lung SAECs 1.60519 0.68274 0.10812 0.5056 DataSet_01_175
FAM189A2 GATA2 siRNA Prostate LNCaP 1.88846 0.91721 0.0909 0.1834 DataSet_01_193
FAM189A2 CREB1 shRNA Parotid_gland HSY 1.65238 0.72455 0.03266 0.51303 DataSet_01_195
FAM189A2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.84295 0.88201 - - DataSet_01_196
FAM189A2 HIC1 shRNA Mammary_gland HBL100 3.51725 1.81445 - - DataSet_01_205
FAM189A2 MITF shRNA Skin COLO829 0.61211 -0.70813 0.22126 0.43388 DataSet_01_207
FAM189A2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.36902 -1.43824 - - DataSet_01_210
FAM189A2 LIN28A siRNA Embryo H9 1.54737 0.62982 0.01535 0.06404 DataSet_01_215
FAM189A2 TWIST1 shRNA Stomach CAF32 0.49658 -1.0099 0.00214 0.02529 DataSet_01_253
FAM189A2 TWIST1 shRNA Stomach CAF 0.60251 -0.73093 0.23669 0.70746 DataSet_01_254
FAM189A2 FOXO3 siRNA Pancreas PANC1 1.51352 0.59791 - - DataSet_01_267
FAM189A2 TFAP4 siRNA Brain BE(2)-C 0.19587 -2.35201 0.33052 0.51625 DataSet_01_295
FAM189A2 PTEN shRNA Lung HCC827 0.62022 -0.68915 0.01839 0.48427 DataSet_01_302
FAM189A2 SOX9 siRNA Prostate VCaP 0.40878 -1.29061 0.02226 0.9316 DataSet_01_308
FAM189A2 SOX9 siRNA Prostate VCaP 0.40878 -1.29061 0.02226 0.9316 DataSet_01_309
FAM189A2 ARNT siRNA Upper_aerodigestive_tract HSC3 4.29549 2.10282 - - DataSet_01_315
FAM189A2 MYC siRNA Colon HCT116 1.86054 0.89572 4.77477e-09 1.11431e-07 DataSet_01_324
FAM189A2 PAX3 shRNA Soft_tissue Rh30 1.67477 0.74396 - - DataSet_01_359
FAM189A2 RBM39 shRNA Liver HepG2 2.25 1.16993 0.89604 0.95273 DataSet_02_111
FAM189A2 SUB1 shRNA Liver HepG2 2.5 1.32193 0.15238 0.33525 DataSet_02_117
FAM189A2 PCBP2 shRNA Liver HepG2 2 1 1 1 DataSet_02_123
FAM189A2 AR siRNA Prostate LNCaP 0.635607 -0.653792 0.343738028299127 1 DataSet_03_005
FAM189A2 ASCL1 siRNA Lung DMS79 1.9084 0.932361 0.0842510853096341 0.743728981726156 DataSet_03_016
FAM189A2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 1.65976 0.730975 - - DataSet_03_096
FAM189A2 GATA2 siRNA Uterus Decidual stromal cells 0.527802 -0.921933 0.0808183620844639 0.705694206023817 DataSet_03_100
FAM189A2 GATA2 siRNA Lymph Lymphatic endothelial cells 2.09308 1.06563 0.0023068412482597 0.00728533285458621 DataSet_03_101
FAM189A2 GATA4 siRNA Stomach YCC3 2.42339 1.27702 0.107737018397567 0.655367565983273 DataSet_03_107
FAM189A2 GATA6 siRNA Stomach YCC3 1.79081 0.840617 0.452173599503753 0.893991054994532 DataSet_03_110
FAM189A2 HNF4a siRNA Liver HepG2 1.79614 0.844902 0.0340923628810052 0.603655043489916 DataSet_03_126
FAM189A2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.99221 0.99437 0.0863578425897287 0.926812735269085 DataSet_03_134
FAM189A2 MYB siRNA Cord_Blood CD34+ progenitor cells 2.6304 1.39529 - - DataSet_03_170
FAM189A2 MYC siRNA Colon HT29 1.78769 0.838095 - - DataSet_03_177
FAM189A2 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.02228 1.01598 0.000400209937593319 0.00300304408382269 DataSet_03_211
FAM189A2 SOX2 siRNA Embryo NTera-2 0.456498 -1.13132 1.47433141611567e-06 0.000386488435518583 DataSet_03_243
FAM189A2 STAT3 CRISPR Embryo hESC 1.69028 0.75726 0.150245487073002 0.216123806505725 DataSet_03_258
FAM189A2 TET1 siRNA Embryo NCCIT 0.449759 -1.15278 1.22408757229991e-05 0.00175002412544518 DataSet_03_269
FAM189A2 TET2 siRNA Embryo NCCIT 0.485366 -1.04286 1.81757415106795e-05 0.00115245732243082 DataSet_03_270
FAM189A2 TET3 siRNA Embryo NCCIT 0.429205 -1.22026 1.92008783332445e-05 0.00264801699001733 DataSet_03_273
FAM189A2 TFE3 siRNA Kidney UOK257-2 1.65391 0.725878 - - DataSet_03_275
FAM189A2 TP63 siRNA Skin Primary neonatal keratinocytes 3.19353 1.67515 2.83328991851172e-05 0.00173953324992974 DataSet_03_281
FAM189A2 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.555556 -0.847997 0.227396158959826 0.611222147766026 DataSet_04_022
FAM189A2 CTCF CRISPR Liver HepG2 3 1.58496 0.000122787564210069 0.165306713898448 DataSet_04_027
FAM189A2 SMAD2 CRISPR Liver HepG2 0.4375 -1.19264 0.159608955257208 0.690090052053902 DataSet_04_034
FAM189A2 APTX CRISPR Liver HepG2 3 1.58496 0.655004299418884 0.969929995678059 DataSet_04_069
FAM189A2 CNOT7 CRISPR Liver HepG2 0.25 -2 0.159386169566946 0.296025670031216 DataSet_04_045
FAM189A2 DNMT3B CRISPR Liver HepG2 0.6 -0.736966 0.820265802057979 0.936527493509761 DataSet_04_044
FAM189A2 CALR shRNA Liver HepG2 5 2.32193 0.698979842957252 0.810408571045692 DataSet_04_053
FAM189A2 CNOT7 shRNA Liver HepG2 3 1.58496 0.892616846246683 0.933519672793874 DataSet_04_051
FAM189A2 UBE2L3 shRNA Liver HepG2 4 2 0.795291268816182 0.885980168649512 DataSet_04_055
FAM189A2 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.253132326525613 0.519160456090219 DataSet_02_38
FAM189A2 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.83333 0.874469 0.717083635341408 0.839623932085876 DataSet_02_34
FAM189A2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.38889 1.25634 0.180989862467698 0.577148223323303 DataSet_02_75
FAM189A2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 12.1667 3.60486 0.134638500745837 0.626148364887373 DataSet_02_45
FAM189A2 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.293562147915536 0.468447180559866 DataSet_02_35
FAM189A2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.66667 2.5025 0.205807837583692 0.487216730977744 DataSet_02_32
FAM189A2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.545455 -0.874469 0.783019115224347 0.96740295412115 DataSet_02_49
FAM189A2 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.760520620581461 0.878776673642238 DataSet_02_43
FAM189A2 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.726797657070185 0.844483032321424 DataSet_02_33
FAM189A2 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.83333 1.9386 0.1688974700691 0.317424127963298 DataSet_02_53
FAM189A2 SMARCA4 siRNA Colon HCT116 1.74083 0.799772 1.153341e-01 9.892536e-01 DataSet_03_301
FAM189A2 ELF3 CRISPR Bile_duct HBDEC2 0.080635 -3.63245 5.201962e-06 2.533834e-04 DataSet_03_304
FAM189A2 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.557721 -0.842385 4.214220e-02 0.6330193 DataSet_03_306
FAM189A2 SNAI2 shRNA Pancreas KLM1 0.38264 -1.38594 3.641812e-02 0.26359878 DataSet_03_307
FAM189A2 ACTR5 siRNA Muscle RD 0.582775 -0.778989 - - DataSet_03_343
FAM189A2 INO80 siRNA Muscle RD 2.55183 1.35153 - - DataSet_03_344
FAM189A2 EZH2 knockdown Colon HCT116 1.67574 0.7448 0.552249630 0.9967254 DataSet_03_334
FAM189A2 TET1 CRISPR Mammary_gland Hs578T 0.627819 -0.67158 7.392916e-01 8.578321e-01 DataSet_03_355
FAM189A2 CREBBP CRISPR Brain U5-NPC 2 1 0.2695037898 0.7490853 DataSet_03_356
FAM189A2 PTPN14 CRISPR Brain U5-NPC 24 4.58496 2.827192e-01 0.50493405 DataSet_03_357
FAM189A2 ZNF213 siRNA Mammary_gland MCF7 0.151428 -2.7233 1.025369e-01 5.174194e-01 DataSet_03_376
FAM189A2 EZH2 CRISPR Ovary SKOV3 0.294479 -1.76377 4.030098e-02 0.1708784514 DataSet_03_378
FAM189A2 NFKB2 siRNA Bone_marrow U2OS 0.428571 -1.22239 1.170574e-01 0.40962019 DataSet_03_381
FAM189A2 DNMT1 siRNA Skin Human melanoma cells 0.662628 -0.593729 1.811630e-02 3.634656e-02 DataSet_03_382
FAM189A2 NFKBIA shRNA Bone_marrow U2OS 0.0153098 -6.0294 2.807397e-01 0.87005461 DataSet_03_389
FAM189A2 ILF2 siRNA Stomach SGC-7901 1.96774 0.976541 0.0053462515 0.02705128 DataSet_03_393
FAM189A2 ASXL1 CRISPR Embryo iPSC 4.84095 2.27529 0.0616553210 0.8048302 DataSet_03_394
FAM189A2 HMGA1 shRNA Bile_duct HUCCT1 1.75 0.807355 5.289505e-01 0.723878232 DataSet_03_400
FAM189A2 EHF shRNA Stomach MKN7 0.153801 -2.70086 - - DataSet_03_402
FAM189A2 CDK7 shRNA Bone_marrow D458 80 6.32193 4.823491e-06 0.01744429 DataSet_03_404
FAM189A2 SATB2 CRISPR Colon Colon organoid 2.41284 1.27073 5.749630e-02 0.95735254 DataSet_03_406
FAM189A2 CHD1 shRNA Prostate LNCaP 0.621849 -0.685364 5.610921e-02 4.922564e-01 DataSet_03_407
FAM189A2 STRAP knockout Nerve SK-N-AS 1.62155 0.69737 - - DataSet_03_409
FAM189A2 E2F2 siRNA Prostate LNCaP 1.66316 0.733925 5.297891e-02 1.945919e-01 DataSet_03_414
FAM189A2 FOXK2 shRNA Ovary OVCAR-5 0.588235 -0.765535 3.447239e-01 0.46374931 DataSet_03_419
FAM189A2 USP7 shRNA Skin xenograft cells 0.37431 -1.41769 0.26065920 0.4348960 DataSet_03_431
FAM189A2 PHF14 siRNA Mammary_gland MDA-MB-231 0.581081 -0.783189 0.0946229035 0.5119325 DataSet_03_443
FAM189A2 CBX2 siRNA Mammary_gland MCF7 4.54606 2.18462 2.837470e-04 0.0025057900 DataSet_03_451
FAM189A2 ARID1A shRNA Bile_duct MMNK1 2.76538 1.46748 5.104231e-01 0.700372305 DataSet_03_458
FAM189A2 STAT3 shRNA Liver HepG2 1.66667 0.736966 3.620149e-01 0.6019472288 DataSet_03_465
FAM189A2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.6566264 0.9266861 DataSet_04_072
FAM189A2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.9113673 0.958255332 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate CDK7 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of FAM189A2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines