Gene Overview
Target Gene: FGF5
NCBI Official Symbol: FGF5
Entrez ID: 2250
Ensembl ID: ENSG00000138675
Gene Full Name: fibroblast growth factor 5
Strand: +
Gene Locus: 4q21.21
External Links:

FGF5 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate FGF5   
T(co)Fs that Repress FGF5
The Intensity of the Gene Regulated by T(co)Fs:
FGF5-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
FGF5 HOXA1 siRNA Lung_fibroblast IMR-90 0.29766 -1.74824 0.00019 0.01474 DataSet_01_110
FGF5 ID1 siRNA Lung H1650 3.86694 1.95119 0.01042 0.32206 DataSet_01_118
FGF5 FOXM1 siRNA Central_nervous_system U87 4.34989 2.12098 - - DataSet_01_122
FGF5 ZFX shRNA Central_nervous_system DAOY 1.79734 0.84587 0.07329 0.99991 DataSet_01_157
FGF5 JUN siRNA Peripheral_blood CD4+ T cells 0.64884 -0.62407 0.15797 0.38133 DataSet_01_164
FGF5 FOSL1 siRNA Mammary_gland BT549 1.74335 0.80186 1.98588e-05 0.00224 DataSet_01_171
FGF5 JUN siRNA Mammary_gland BT549 1.73806 0.79748 0.00041 0.03191 DataSet_01_172
FGF5 GABPA shRNA Prostate C4-2B 1536.32 10.5853 0.23742 0.43934 DataSet_01_190
FGF5 GABPA shRNA Prostate LNCaP 948.446 9.88942 0.4648 0.7048 DataSet_01_191
FGF5 CREB1 shRNA Parotid_gland H3118 MEC 2.3189 1.21344 0.75057 0.9039 DataSet_01_194
FGF5 TP63 siRNA Head_and_neck SCC-012 1.59585 0.67432 - - DataSet_01_201
FGF5 TP63 siRNA Head_and_neck SCC-6 1.93538 0.95262 - - DataSet_01_202
FGF5 LIN28A siRNA Embryo H9 1.99654 0.9975 0.00224 0.01997 DataSet_01_215
FGF5 SNAI2 shRNA Skin Primary human keratinocytes 0.47457 -1.07532 0.00159 0.01806 DataSet_01_225
FGF5 IRX1 shRNA Bone_marrow 143B 0.57657 -0.79444 5.35169e-05 0.01037 DataSet_01_227
FGF5 ESR2 siRNA Mammary_gland BT549 2.08975 1.06333 2.47686e-07 2.93516e-05 DataSet_01_229
FGF5 JUN shRNA Soft_tissue LP6 0.54052 -0.88757 0.00222 0.24255 DataSet_01_230
FGF5 MYC shRNA Soft_tissue HT1080 0.54253 -0.88223 - - DataSet_01_237
FGF5 TWIST1 shRNA Stomach CAF32 0.54308 -0.88077 0.00867 0.04807 DataSet_01_253
FGF5 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.54139 0.62423 0.11605 0.8736 DataSet_01_290
FGF5 POSTN shRNA Brain GSC272 2.32533 1.21744 0.07037 0.54065 DataSet_01_293
FGF5 TFAP4 siRNA Brain BE(2)-C 0.13784 -2.85893 0.26207 0.51625 DataSet_01_295
FGF5 PTEN shRNA Lung HCC827 2.47707 1.30863 0.01679 0.4782 DataSet_01_302
FGF5 SOX9 siRNA Prostate VCaP 0.56837 -0.8151 0.12898 0.9316 DataSet_01_308
FGF5 SOX9 siRNA Prostate VCaP 0.56837 -0.8151 0.12898 0.9316 DataSet_01_309
FGF5 BRD4 siRNA Ovary Ovcar8 0.49893 -1.00308 0.00147 0.01009 DataSet_01_311
FGF5 TFAP2C siRNA Lung NCI-H292 1.94836 0.96226 - - DataSet_01_312
FGF5 ARNT siRNA Upper_aerodigestive_tract HSC3 1.51361 0.59799 - - DataSet_01_315
FGF5 ELK3 shRNA Mammary_gland MDA-MB-231 0.45127 -1.14792 1.58549e-05 0.00017 DataSet_01_318
FGF5 KLF7 siRNA Embryo HCE 0.53197 -0.91059 0.15891 0.6419 DataSet_01_340
FGF5 ETV4 shRNA Prostate PC3 0.46478 -1.10537 - - DataSet_01_356
FGF5 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.41451 1.27173 0.00165 0.02792 DataSet_02_131
FGF5 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55959 0.64116 0.0053 0.08589 DataSet_02_135
FGF5 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.8342 0.87515 0.02841 0.22337 DataSet_02_141
FGF5 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.488 -1.03505 0.03417 0.07679 DataSet_02_143
FGF5 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 1.61905 0.69515 0.14898 0.52827 DataSet_02_145
FGF5 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 1.56842 0.64931 0.06334 0.28089 DataSet_02_155
FGF5 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.68 0.74846 0.00598 0.72836 DataSet_02_157
FGF5 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55789 0.6396 0.11114 0.60348 DataSet_02_162
FGF5 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.57962 -0.78683 0.0813 1 DataSet_02_173
FGF5 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.50376 0.58857 0.15481 1 DataSet_02_174
FGF5 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.26852 1.18175 0.21542 1 DataSet_02_178
FGF5 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.975 1.57289 0.04992 1 DataSet_02_179
FGF5 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 1.76866 0.82265 0.15998 1 DataSet_02_183
FGF5 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.7027 0.76783 0.47509 1 DataSet_02_188
FGF5 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.31776 1.21273 0.18788 1 DataSet_02_191
FGF5 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.62162 -0.68589 0.22195 1 DataSet_02_192
FGF5 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 2.84259 1.50721 0.31035 1 DataSet_02_203
FGF5 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 0.65405 -0.61252 0.09521 1 DataSet_02_205
FGF5 AR siRNA Prostate abl cells 1.936 0.953079 0.114223343001018 0.999852161656754 DataSet_03_004
FGF5 AR siRNA Prostate LNCaP 2.1236 1.08651 0.173803668756985 1 DataSet_03_005
FGF5 ASCL1 siRNA Lung DMS79 3.72727 1.89812 0.134989812973719 0.802584126635319 DataSet_03_016
FGF5 ATF4 siRNA Skin A375 0.657947 -0.603956 0.202648744775259 0.775512819201899 DataSet_03_018
FGF5 CASP8AP2 siRNA Bone_marrow U2OS 0.444884 -1.1685 1.73719136923369e-05 0.00133050652510872 DataSet_03_031
FGF5 CEBPB siRNA Embryo hESC 2.83051 1.50106 0.00754060488680646 0.203796005877047 DataSet_03_049
FGF5 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.550454 -0.861305 - - DataSet_03_096
FGF5 GATA4 siRNA Stomach KatoIII 0.458408 -1.1253 0.035815223596362 0.858226079874734 DataSet_03_106
FGF5 HNF4a siRNA Liver HepG2 1.85052 0.887927 0.0649537742873598 0.670755356315106 DataSet_03_126
FGF5 MYB siRNA Cord_Blood CD34+ progenitor cells 1.56163 0.64305 - - DataSet_03_170
FGF5 PRRX1 CRISPR Neuroblastoma 691-MES 2.03196 1.02287 0.0870815151302718 0.89189998148014 DataSet_03_217
FGF5 SOX11 siRNA Lung_fibroblast NHLF 0.550811 -0.860371 0.0245955189630116 0.252284066674275 DataSet_03_238
FGF5 STAT3 CRISPR Embryo hESC 1.9835 0.988051 0.000666521019433384 0.0196031128167989 DataSet_03_258
FGF5 TFE3 siRNA Kidney UOK257-2 2.61376 1.38612 - - DataSet_03_275
FGF5 TWIST1 siRNA Bone_marrow MSCs 0.498784 -1.00351 - - DataSet_03_283
FGF5 ZNF165 siRNA Mammary_gland SUM159 2.2416 1.16453 0.598820510950666 0.999998167536832 DataSet_03_288
FGF5 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.52727 0.610958 0.0372646530781447 0.534901989468182 DataSet_04_001
FGF5 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.643617 -0.635726 0.0775534621894101 0.125965134529985 DataSet_04_012
FGF5 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 87.0784 6.44424 0.000288694510139559 0.00606025653139736 DataSet_04_014
FGF5 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.515957 -0.954676 0.0232025197417348 0.054841521311622 DataSet_04_015
FGF5 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.76042 0.815917 0.0226788296340605 0.107802394753565 DataSet_04_018
FGF5 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.08421 1.0595 0.0491979050874069 0.50563800196105 DataSet_04_022
FGF5 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.70395 0.768881 0.431967752696668 0.609085179644604 DataSet_02_34
FGF5 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.565789 -0.821663 0.0907561146261727 0.193216581327878 DataSet_02_35
FGF5 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.605263 -0.724366 0.092663334698388 0.412228616888281 DataSet_02_32
FGF5 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.54605 0.628589 0.639630970044782 0.772692703777092 DataSet_02_47
FGF5 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.01575 1.01132 0.296486614850219 0.701443627527024 DataSet_02_49
FGF5 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.598684 -0.740133 0.116420741648475 0.252321785612387 DataSet_02_43
FGF5 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.638158 -0.648015 0.131719719976662 0.240295127937824 DataSet_02_33
FGF5 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.632979 -0.659771 0.0672214171252304 0.129203560095344 DataSet_04_059
FGF5 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 1.77011 0.823843 0.0139313332430985 0.260679372307201 DataSet_04_065
FGF5 SMARCA4 siRNA Colon HCT116 3.27345 1.71081 3.037232e-02 5.902803e-01 DataSet_03_301
FGF5 INO80 siRNA Muscle RD 1.75369 0.810392 - - DataSet_03_344
FGF5 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 0.628725 -0.669498 1.366295e-02 2.818582e-01 DataSet_03_311
FGF5 TET1 CRISPR Mammary_gland MDA-MB-231 15.492 3.95345 2.364483e-05 1.019403e-03 DataSet_03_347
FGF5 EZH2 shRNA Mammary_gland LM2 1.69674 0.762768 1.034377e-02 1.631603e-01 DataSet_03_350
FGF5 SKI CRISPR Blood HL60 0.638889 -0.646363 3.285984e-02 0.320431511 DataSet_03_351
FGF5 CREBBP CRISPR Brain U5-NPC 1.58333 0.662965 0.2993675867 0.7490853 DataSet_03_356
FGF5 PTPN14 CRISPR Brain U5-NPC 1.62 0.695994 9.602927e-01 0.97996787 DataSet_03_357
FGF5 NCOA3 siRNA Mammary_gland MDA-MB-231 1.77901 0.831076 1.066398e-01 0.6031133 DataSet_03_361
FGF5 EP300 shRNA Mammary_gland MCF10AT 0.5 -1 7.302519e-01 0.831628217 DataSet_03_364
FGF5 ZNF148 shRNA Mammary_gland MDA-MB-231 0.337178 -1.56842 1.183805e-03 0.030244952 DataSet_03_366
FGF5 DNMT3A knockout Embryo_kidney HEK293T 2.14498 1.10096 - - DataSet_03_369
FGF5 TPR shRNA Bone_marrow U2OS 0.458112 -1.12623 2.373037e-06 6.901719e-04 DataSet_03_370
FGF5 EZH2 CRISPR Ovary SKOV3 0.505938 -0.982967 1.257435e-02 0.0867206727 DataSet_03_378
FGF5 DNMT1 siRNA Skin Human melanoma cells 2.77466 1.47231 1.474005e-02 3.041267e-02 DataSet_03_382
FGF5 YY1 shRNA Brain GSC1517 0.498629 -1.00396 - - DataSet_03_384
FGF5 YY1 shRNA Brain GSC23 0.596246 -0.746022 - - DataSet_03_385
FGF5 YY1 shRNA Brain GSC3028 3.998 1.99928 - - DataSet_03_386
FGF5 TRIM8 siRNA Mammary_gland MCF7 0.6 -0.736966 7.895971e-01 0.8790437802 DataSet_03_388
FGF5 NFKBIA shRNA Bone_marrow U2OS 0.517201 -0.951204 2.788690e-01 0.87005461 DataSet_03_389
FGF5 PRDM15 CRISPR Kidney Immortalized human podocytes 0.216167 -2.20978 1.854966e-02 6.868935e-02 DataSet_03_391
FGF5 KDM5A CRISPR Lung GLC16 0.469056 -1.09217 1.324565e-04 0.012041984 DataSet_03_392
FGF5 ILF2 siRNA Stomach SGC-7901 0.166667 -2.58496 0.2186493921 0.40346604 DataSet_03_393
FGF5 RELA CRISPR Brain T30 1.59535 0.673869 0.3358044696 0.8400824 DataSet_03_399
FGF5 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.83171 0.873189 2.078807e-02 0.3239928 DataSet_03_403
FGF5 CDK7 shRNA Bone_marrow D458 3.5 1.80735 4.809787e-02 0.30876950 DataSet_03_404
FGF5 TFAP2A knockout Embryo H9 156.5 7.29002 1.073474e-03 0.02643820 DataSet_03_405
FGF5 SIRT1 siRNA Pancreas PANC1 1.78006 0.831925 9.017002e-04 0.017877361 DataSet_03_410
FGF5 USP7 shRNA Skin xenograft cells 0.519672 -0.944326 0.51094005 0.6384760 DataSet_03_431
FGF5 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 6.47124 2.69404 1.819728e-02 0.383224633 DataSet_03_434
FGF5 POU2AF1 CRISPR Lymph SUDHL4 2 1 6.736348e-01 0.754244614 DataSet_03_435
FGF5 DAXX shRNA Mammary_gland MDA-MB-231 0.452048 -1.14545 6.598910e-02 0.28567577 DataSet_03_441
FGF5 HMG20A siRNA Mammary_gland MDA-MB-231 2.37957 1.2507 0.0136051877 0.1764088 DataSet_03_442
FGF5 PHF14 siRNA Mammary_gland MDA-MB-231 1.89957 0.925676 0.0314406242 0.3778086 DataSet_03_443
FGF5 FOSL1 siRNA Prostate MSKPCa3 0.509031 -0.974174 0.0043978724 0.2237808 DataSet_03_445
FGF5 CBX2 siRNA Mammary_gland MDA-MB-231 2.00403 1.00291 3.103684e-02 1.064813e-01 DataSet_03_450
FGF5 SREBF2 siRNA Umbilical_vein HUVEC 0.320496 -1.64162 4.165375e-01 8.039044e-01 DataSet_03_457
FGF5 ARID1A shRNA Bile_duct MMNK1 2.12962 1.0906 6.166812e-04 0.023431543 DataSet_03_458
FGF5 PARP1 knockout Embryo_kidney HEK293a 1.77746 0.829821 1.220670e-05 1.137397e-04 DataSet_03_464
FGF5 SMARCA1 Cas13 Embryo_kidney HEK293T 0.431818 -1.2115 - - DataSet_03_466
FGF5 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.72727 0.788496 - - DataSet_03_467
FGF5 EZH2 siRNA Umbilical_vein HUVEC 2.0303 1.0217 1.687543e-02 0.169557549 DataSet_03_473
FGF5 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.52727 0.610958 0.04059407 0.4443814 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate TFAP2A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of FGF5
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines