Gene Overview
Target Gene: HBA2
NCBI Official Symbol: HBA2
Entrez ID: 3040
Ensembl ID: ENSG00000188536
Gene Full Name: hemoglobin subunit alpha 2
Strand: +
Gene Locus: 16p13.3
External Links:

HBA2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate HBA2   
T(co)Fs that Repress HBA2
The Intensity of the Gene Regulated by T(co)Fs:
HBA2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
HBA2 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 1.60621 0.68366 3.2758e-08 9.55947e-07 DataSet_01_102
HBA2 FOXA1 shRNA Prostate 22RV1 0.34375 -1.54056 - - DataSet_01_105
HBA2 HOXA1 siRNA Lung_fibroblast IMR-90 1.58097 0.66081 0.39758 0.66638 DataSet_01_110
HBA2 ESRRG siRNA Placenta_tissue Trophoblast cells 1.85671 0.89275 0.00484 0.08373 DataSet_01_173
HBA2 GABPA shRNA Prostate C4-2B 2215.01 11.1131 0.23725 0.43934 DataSet_01_190
HBA2 GABPA shRNA Prostate LNCaP 1597.32 10.6414 0.46263 0.7048 DataSet_01_191
HBA2 REST siRNA Prostate LNCaP 2.18004 1.12436 0.01077 0.1762 DataSet_01_211
HBA2 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.50674 -0.98069 0.00148 0.01745 DataSet_01_217
HBA2 KLF3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.75117 1.46005 3.35031e-11 5.35519e-08 DataSet_01_221
HBA2 YBX1 shRNA Mammary_gland MDA 1.96583 0.97514 3.3761e-06 0.00026 DataSet_01_257
HBA2 YBX1 shRNA Mammary_gland MDA 0.65711 -0.6058 0.00325 0.06868 DataSet_01_258
HBA2 SIX4 siRNA Ovary PEO1 1.66696 0.73722 0.03315 0.1505 DataSet_01_269
HBA2 CREB1 shRNA Haematopoietic_and_lymphoid_tissue Nalm6 0.4616 -1.11529 5e-04 0.99932 DataSet_01_274
HBA2 ESRRA shRNA Embryo_kidney 293T 0.4992 -1.00232 0.00662 0.50362 DataSet_01_280
HBA2 HNF4G shRNA Prostate 22RV1 0.6653 -0.58791 5.19749e-07 0.00051 DataSet_01_320
HBA2 RBM17 shRNA Liver HepG2 0.23656 -2.07973 0.00317 0.26816 DataSet_02_100
HBA2 RBM39 shRNA Liver HepG2 0.19355 -2.36923 0.03835 0.23862 DataSet_02_111
HBA2 PCBP1 shRNA Liver HepG2 2 1 0.05914 0.10468 DataSet_02_115
HBA2 RBM25 shRNA Liver HepG2 3.8 1.926 0.03149 0.07744 DataSet_02_119
HBA2 FUS shRNA Liver HepG2 0.55172 -0.85798 0.09007 0.2406 DataSet_02_124
HBA2 SRSF3 shRNA Liver HepG2 0.18391 -2.44294 0.03406 0.13057 DataSet_02_127
HBA2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 3.6616 1.87248 0.00336 0.23929 DataSet_02_129
HBA2 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.63458 -0.65613 0.09482 0.72262 DataSet_02_130
HBA2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.65117 1.40663 0.00256 0.02982 DataSet_02_131
HBA2 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.91078 1.96746 0.00312 0.09316 DataSet_02_132
HBA2 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 1.62947 0.7044 0.07984 0.30939 DataSet_02_133
HBA2 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 2.67359 1.41878 0.00695 0.09313 DataSet_02_134
HBA2 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.73091 0.79153 0.01713 0.21468 DataSet_02_137
HBA2 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.57684 -0.79376 0.9899 1 DataSet_02_140
HBA2 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.76564 0.82019 0.02724 0.22277 DataSet_02_141
HBA2 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.03522 1.02518 0.00254 0.08876 DataSet_02_142
HBA2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 3.50559 1.80966 0.00049 0.02038 DataSet_02_143
HBA2 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 1.6319 0.70655 0.03572 0.51061 DataSet_02_145
HBA2 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.06046 1.04297 0.00407 0.08379 DataSet_02_147
HBA2 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 2.4121 1.27029 0.01944 0.19507 DataSet_02_149
HBA2 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.62677 -0.674 0.05698 0.32396 DataSet_02_152
HBA2 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.46995 -1.08942 0.09898 0.4169 DataSet_02_154
HBA2 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.79449 0.84357 0.07734 0.51515 DataSet_02_156
HBA2 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 0.60976 -0.71369 0.03226 0.22056 DataSet_02_164
HBA2 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54973 -0.86319 0.11335 0.27868 DataSet_02_165
HBA2 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 4.56027 2.18912 0.00043 0.05289 DataSet_02_168
HBA2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.50699 -0.97997 0.00077 0.04354 DataSet_02_169
HBA2 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.59765 -0.74262 0.0602 0.15172 DataSet_02_170
HBA2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.37887 -1.40022 0.02246 0.2135 DataSet_02_171
HBA2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.50423 -0.98783 0.9395 1 DataSet_02_190
HBA2 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 12.2507 3.6148 0.04641 0.15655 DataSet_02_196
HBA2 ZFX siRNA Mammary_gland MCF7 4.02439 2.00877 0.24128 0.48229 DataSet_02_206
HBA2 HIC1 CRISPR Prostate PC3 0.634362 -0.656621 - - DataSet_03_118
HBA2 PPARG siRNA Peripheral_blood GM-CSF Macrophage 1.5923 0.671111 0.127793324186381 0.926875493416204 DataSet_03_214
HBA2 SOX11 siRNA Lung_fibroblast NHLF 0.528941 -0.918822 0.018195384335976 0.318136719471454 DataSet_03_237
HBA2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 2.16284 1.11293 0.0156642131198321 0.0729532402987646 DataSet_04_002
HBA2 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.15697 -2.67144 0.00802084662150672 0.0373886427155422 DataSet_04_004
HBA2 CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 0.436141 -1.19713 0.00356747302617877 0.332587786395324 DataSet_04_005
HBA2 DDX59 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.82752 0.869889 0.00326691692532687 0.497685094328772 DataSet_04_006
HBA2 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.664475 -0.589713 0.0775960804095881 0.489628380736371 DataSet_04_008
HBA2 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.10598 1.63505 0.000565742820669343 0.0536237768466547 DataSet_04_010
HBA2 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.60611 0.683568 0.0956743975196706 0.149004435084868 DataSet_04_012
HBA2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.0605785 -4.04505 0.0116188306270316 0.0543953527377036 DataSet_04_014
HBA2 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 5.05411 2.33746 0.0033769482252067 0.0191779959662421 DataSet_04_015
HBA2 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.447877 -1.15883 0.0835262265014358 0.475185222000442 DataSet_04_017
HBA2 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.59941 0.677537 0.132288425659831 0.265467615819841 DataSet_04_018
HBA2 SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.606254 -0.722006 0.00209759952691384 0.0979887211869635 DataSet_04_019
HBA2 XRCC5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.529184 -0.918158 0.0116338591680461 0.177380922509035 DataSet_04_021
HBA2 ANXA2 CRISPR Liver HepG2 1.52397 0.607837 0.0118965576107861 0.577364782982721 DataSet_04_024
HBA2 APTX CRISPR Liver HepG2 4.25 2.08746 0.391252152703215 0.897632790938297 DataSet_04_069
HBA2 CNOT7 CRISPR Liver HepG2 0.357143 -1.48543 0.07818473812561 0.179827319768771 DataSet_04_045
HBA2 SEPT11 CRISPR Liver HepG2 2.375 1.24793 0.529161237438669 0.756558544484959 DataSet_04_068
HBA2 ABT1 shRNA Liver HepG2 4.125 2.04439 0.0459004837389232 0.104390728081904 DataSet_04_052
HBA2 UBE2L3 shRNA Liver HepG2 8.22222 3.03953 0.277096410347241 0.425534785740521 DataSet_04_055
HBA2 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.89302 0.920691 0.0030241091995801 0.0528876140396299 DataSet_04_048
HBA2 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.643826 -0.635258 0.00816357444348166 0.51971586028101 DataSet_04_076
HBA2 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.495756 -1.0123 0.094745341229114 0.512748991761346 DataSet_04_073
HBA2 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.41293 -1.27603 0.00155296020637848 0.36988468995597 DataSet_04_075
HBA2 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.632033 -0.661929 0.020029356477876 0.0669538247084536 DataSet_04_049
HBA2 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.656627 -0.606854 0.000532732489677861 0.0083745149806643 DataSet_02_14
HBA2 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.519724 -0.944181 0.000185864681425671 0.00829705207032081 DataSet_02_33
HBA2 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.9261 0.945682 0.000604807165350172 0.0368569037031281 DataSet_04_064
HBA2 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 2.8044 1.48769 0.00523595441269237 0.0188288153095063 DataSet_04_059
HBA2 PATZ1 siRNA Liver HepG2 1.73494 0.794887 1.422216e-05 3.519033e-03 DataSet_03_296
HBA2 PATZ1 siRNA Liver HepG2 1.73494 0.794887 1.422216e-05 3.519033e-03 DataSet_03_297
HBA2 SMARCA4 siRNA Colon HCT116 1.8552 0.891574 8.213597e-02 9.151691e-01 DataSet_03_301
HBA2 ACTR5 siRNA Muscle RD 0.64201 -0.639333 - - DataSet_03_343
HBA2 EZH2 knockdown Colon HCT116 0.451023 -1.14873 0.306501162 0.9282226 DataSet_03_334
HBA2 ESR1 siRNA Mammary_gland MCF7 0.490362 -1.02808 2.283988e-03 0.0289677492 DataSet_03_352
HBA2 ETV5 knockdown Colon HT29 5 2.32193 2.642804e-01 0.527308910 DataSet_03_353
HBA2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.383025 -1.38449 4.603551e-01 6.921420e-01 DataSet_03_359
HBA2 TP53 knockout Stomach SNU1 0.175933 -2.5069 0.2866920320 0.9301241 DataSet_03_365
HBA2 USP22 shRNA Liver PLC_PRF_5 cells 0.184211 -2.44057 2.740218e-02 0.17042805 DataSet_03_368
HBA2 DNMT3A knockout Embryo_kidney HEK293T 4.50362 2.17108 - - DataSet_03_369
HBA2 TPR shRNA Bone_marrow U2OS 1.90135 0.927024 2.214961e-01 6.547258e-01 DataSet_03_370
HBA2 BHLHE40 shRNA Cervix HeLaS3 3.05312 1.61028 1.122871e-01 0.84447131 DataSet_03_372
HBA2 GLI1 siRNA Skeletal_muscle RMS13 2.03728 1.02665 5.457356e-01 0.710001168 DataSet_03_375
HBA2 ZNF213 siRNA Mammary_gland MCF7 0.615511 -0.700145 3.060300e-02 3.199294e-01 DataSet_03_376
HBA2 SMARCA2 shRNA Lung NCI-H1944 0.491176 -1.02569 2.993891e-02 3.241034e-01 DataSet_03_377
HBA2 DNMT1 siRNA Skin Human melanoma cells 0.29116 -1.78012 4.593114e-02 8.165970e-02 DataSet_03_382
HBA2 KDM5A CRISPR Lung GLC16 15.6138 3.96475 3.088992e-03 0.024340604 DataSet_03_392
HBA2 ASXL1 CRISPR Embryo iPSC 2.00469 1.00338 0.3936494588 0.8410775 DataSet_03_394
HBA2 BMI1 shRNA Bile_duct QBC-939 0.523339 -0.934182 8.949154e-04 0.0070272129 DataSet_03_395
HBA2 CDK7 shRNA Bone_marrow D458 3.64286 1.86507 5.914350e-03 0.13950446 DataSet_03_404
HBA2 SIRT1 siRNA Pancreas PANC1 3 1.58496 1.269215e-01 0.259183876 DataSet_03_410
HBA2 RUNX2 shRNA Cord_blood Natural Killer Cell 0.046875 -4.41504 7.723831e-02 0.793390621 DataSet_03_416
HBA2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.5 -1 6.034480e-01 0.723818496 DataSet_03_418
HBA2 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.278846 -1.84246 0.2860706078 1 DataSet_03_430
HBA2 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.492958 -1.02046 - - DataSet_03_432
HBA2 DAXX shRNA Mammary_gland MDA-MB-231 2.03454 1.02471 5.987246e-01 0.82426075 DataSet_03_441
HBA2 OGT siRNA Embryo BeWo cells 0.0909091 -3.45943 2.591407e-01 0.66237450 DataSet_03_453
HBA2 PPARG siRNA Aortic_valve Valvular endothelial cell 1.89189 0.91983 3.411769e-01 7.508584e-01 DataSet_03_456
HBA2 HAND1 siRNA Placenta HPMVEC 0.214286 -2.22239 3.715585e-02 0.9463341 DataSet_03_459
HBA2 IRF2 shRNA Cord_Blood CD34+ cells 0.323338 -1.62889 - - DataSet_03_460
HBA2 TXNIP shRNA Cord_Blood CD34+ cells 4.66667 2.22239 - - DataSet_03_461
HBA2 TXNIP shRNA Cord_blood ST3 0.0542776 -4.2035 1.103556e-04 0.0177946026 DataSet_03_462
HBA2 PARP1 knockout Embryo_kidney HEK293a 5.75 2.52356 1.628818e-06 2.122433e-05 DataSet_03_464
HBA2 STAT3 shRNA Liver HepG2 2.39623 1.26076 1.641883e-02 0.1970766975 DataSet_03_465
HBA2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 11 3.45943 - - DataSet_03_467
HBA2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 2.16284 1.11293 0.004953132 0.028973354 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate OGT by the evidences of both expression and ChIP-seq/motif
Expression Atlas of HBA2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines