Gene Overview
Target Gene: IGF1
NCBI Official Symbol: IGF1
Entrez ID: 3479
Ensembl ID: ENSG00000017427
Gene Full Name: insulin like growth factor 1
Strand: -
Gene Locus: 12q23.2
External Links:

IGF1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate IGF1   
T(co)Fs that Repress IGF1
The Intensity of the Gene Regulated by T(co)Fs:
IGF1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
IGF1 REST siRNA Adrenal_gland H295R/TR 0.54487 -0.876 0.00055 0.0503 DataSet_01_145
IGF1 SF1 siRNA Adrenal_gland H295R/TR 3.06353 1.6152 6.5994e-06 0.00041 DataSet_01_146
IGF1 HOXB7 siRNA Pancreas Capan-1 0.57934 -0.78753 0.00828 0.43018 DataSet_01_170
IGF1 TP53 siRNA Lung SAECs 1.56156 0.64299 0.31332 0.70388 DataSet_01_175
IGF1 GABPA shRNA Prostate C4-2B 885.971 9.79112 0.238 0.43934 DataSet_01_190
IGF1 GABPA shRNA Prostate LNCaP 899.88 9.81359 0.4667 0.7048 DataSet_01_191
IGF1 GATA2 siRNA Prostate LNCaP 0.60682 -0.72067 0.02303 0.06571 DataSet_01_193
IGF1 CREB1 shRNA Parotid_gland H3118 MEC 3.17909 1.66861 0.31069 0.66769 DataSet_01_194
IGF1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.50988 0.59444 - - DataSet_01_197
IGF1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.55596 -0.84694 - - DataSet_01_208
IGF1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.38584 -1.37392 - - DataSet_01_209
IGF1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.53246 -0.90925 - - DataSet_01_210
IGF1 KLF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.48376 -1.04764 4.61987e-09 1.03755e-06 DataSet_01_221
IGF1 MYC siRNA White_adipose_tissue Adipose stem cells 0.21374 -2.22605 7.50025e-06 0.00061 DataSet_01_231
IGF1 FOXA1 siRNA Prostate LNCaP 0.37366 -1.42019 0.03231 0.27423 DataSet_01_233
IGF1 FOXP1 siRNA Prostate LNCaP 1.77808 0.83032 0.18342 0.60711 DataSet_01_234
IGF1 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.43283 -1.20813 2.46586e-05 0.00072 DataSet_01_239
IGF1 ESRRA shRNA Embryo_kidney 293T 1.8308 0.87247 0.35585 0.82889 DataSet_01_280
IGF1 AHR siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.65963 -0.60027 0.00333 0.02298 DataSet_01_283
IGF1 POSTN shRNA Brain GSC272 2.0475 1.03386 0.10932 0.55574 DataSet_01_293
IGF1 TFAP4 siRNA Brain BE(2)-C 0.16106 -2.6343 0.27727 0.51625 DataSet_01_295
IGF1 SOX7 siRNA Umbilical_vein HUVEC 2.10162 1.0715 0.01852 0.89788 DataSet_01_299
IGF1 PTEN shRNA Mammary_gland SKBR3 2.32853 1.21942 0.10662 0.61614 DataSet_01_303
IGF1 ARNT siRNA Upper_aerodigestive_tract HSC3 1.90736 0.93157 - - DataSet_01_315
IGF1 MYC siRNA Colon HCT116 1.60088 0.67886 0.02715 0.04806 DataSet_01_324
IGF1 SOX17 siRNA Umbilical_vein HUVEC 0.22703 -2.13902 - - DataSet_01_360
IGF1 GTF2B siRNA Cervix HeLa 0.5917 -0.75706 - - DataSet_01_362
IGF1 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 1.58224 0.66197 0.18951 0.47862 DataSet_02_129
IGF1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 5.27961 2.40043 0.00046 0.02779 DataSet_02_131
IGF1 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4204 -1.25017 0.07409 0.21263 DataSet_02_132
IGF1 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 1.85197 0.88906 0.00115 0.22541 DataSet_02_133
IGF1 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 1.83224 0.87361 0.27817 0.4969 DataSet_02_136
IGF1 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.80263 1.48678 0.00014 0.18403 DataSet_02_137
IGF1 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.89474 0.922 0.10639 0.31282 DataSet_02_141
IGF1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6463 -0.62972 0.01476 0.04597 DataSet_02_143
IGF1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 4.7728 2.25484 0.00168 0.19727 DataSet_02_144
IGF1 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 1.82863 0.87077 0.03426 0.51061 DataSet_02_145
IGF1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.45 -1.152 0.03062 0.12432 DataSet_02_147
IGF1 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.50323 0.58806 0.03008 0.44766 DataSet_02_150
IGF1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.83333 1.5025 9e-04 0.23369 DataSet_02_152
IGF1 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 5.65789 2.50027 0.00103 0.4089 DataSet_02_153
IGF1 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 1.92442 0.94442 0.13483 0.45307 DataSet_02_154
IGF1 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 1.66082 0.73189 0.20308 0.43794 DataSet_02_155
IGF1 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.51627 0.60053 0.09306 0.51515 DataSet_02_156
IGF1 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55556 -0.848 0.24162 0.37263 DataSet_02_158
IGF1 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 1.94767 0.96175 0.09688 0.66967 DataSet_02_159
IGF1 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.00581 1.00419 0.10886 0.73888 DataSet_02_161
IGF1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.10526 1.63472 0.01741 0.53443 DataSet_02_162
IGF1 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.23915 -2.06398 0.79404 0.88921 DataSet_02_163
IGF1 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 2.39181 1.2581 0.04182 0.2291 DataSet_02_164
IGF1 RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 2.30769 1.20645 0.03586 0.21629 DataSet_02_166
IGF1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.39835 -1.32789 0.04618 0.13017 DataSet_02_170
IGF1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2.15659 1.10875 0.02898 0.22431 DataSet_02_171
IGF1 ARID1A siRNA Mammary_gland MDA-MB-157 0.631484 -0.663182 - - DataSet_03_014
IGF1 ATF4 siRNA Skin A375 0.658773 -0.602147 0.178983756729322 0.775512819201899 DataSet_03_018
IGF1 CEBPB siRNA Embryo hESC 1.96951 0.977837 0.51498604382402 0.807288074328973 DataSet_03_049
IGF1 CTNNB1 siRNA Prostate LNCaP 0.640904 -0.64182 0.24187083955636 0.820314207380884 DataSet_03_059
IGF1 EP300 siRNA Prostate LNCaP 1.93604 0.953111 0.950515714829254 0.968972330651181 DataSet_03_065
IGF1 FHL2 siRNA Prostate LNCaP 1.56441 0.645619 0.555934386617762 0.998052494102643 DataSet_03_076
IGF1 GATA2 siRNA Uterus Decidual stromal cells 2.42036 1.27522 0.786391147956286 0.980240039443518 DataSet_03_100
IGF1 GATA4 siRNA Stomach AGS 2.24347 1.16573 0.00948694905096652 0.477767166741116 DataSet_03_105
IGF1 GATA4 siRNA Stomach KatoIII 0.656381 -0.607394 0.246203254434036 0.914908611202096 DataSet_03_106
IGF1 GATA4 siRNA Stomach YCC3 1.96545 0.974861 0.044007141331944 0.583704326956186 DataSet_03_107
IGF1 GATA6 siRNA Stomach KatoIII 0.628634 -0.669707 0.0870747979096709 0.605349564427968 DataSet_03_109
IGF1 GATA6 siRNA Stomach YCC3 3.23711 1.69471 0.000788434357389848 0.167617976548242 DataSet_03_110
IGF1 KLF5 siRNA Stomach YCC3 1.69075 0.757662 0.024792781904808 0.249251481963147 DataSet_03_151
IGF1 MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.550316 -0.861667 0.0369434329118947 1 DataSet_03_155
IGF1 MITF siRNA Skin SK-MEL-5 0.552258 -0.856587 0.000224487499281484 0.00104189993878072 DataSet_03_168
IGF1 MYB siRNA Cord_Blood CD34+ progenitor cells 3.92477 1.97261 - - DataSet_03_170
IGF1 SMARCC1 siRNA Prostate LNCaP 0.506484 -0.981412 0.0621831443965617 0.855603323810147 DataSet_03_236
IGF1 SOX11 siRNA Lung_fibroblast NHLF 1.84324 0.882242 0.0178497695637411 0.318136719471454 DataSet_03_237
IGF1 SOX2 CRISPR Seminoma-like TCam-2 3.57847 1.83934 0.0180077317245061 0.999580851453413 DataSet_03_244
IGF1 SP1 siRNA Ovary OVSAYO 0.639045 -0.646011 0.0955306201226801 0.376659585200266 DataSet_03_251
IGF1 SRF siRNA Prostate LNCaP 2.02576 1.01847 0.0054103545191412 0.0372650213460568 DataSet_03_254
IGF1 STAT3 CRISPR Embryo hESC 3.28733 1.71692 0.0983486900609286 0.184646138362254 DataSet_03_258
IGF1 STAT3 siRNA Prostate LNCaP 1.68104 0.749353 0.191757792298241 0.248574915942164 DataSet_03_262
IGF1 STAT6 siRNA Umbilical_vein HUVEC 0.317422 -1.65552 0.313454313857456 0.876741320594925 DataSet_03_264
IGF1 TFAP2C siRNA Mammary_gland MCF7 0.645312 -0.631932 0.123383309629171 0.476948513034577 DataSet_03_274
IGF1 TFE3 siRNA Kidney UOK257-2 0.542003 -0.883627 - - DataSet_03_275
IGF1 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.435685 -1.19864 0.0030923261973238 0.0469646267288304 DataSet_04_002
IGF1 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.63004 1.39509 0.000142415155403285 0.018311055901814 DataSet_04_004
IGF1 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.78641 1.47841 0.027272017059137 0.0577368019397251 DataSet_04_012
IGF1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 1.79858 0.846861 0.431816882435427 0.575416885931922 DataSet_04_014
IGF1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.55054 0.632769 0.00955062303617115 0.0844320405656502 DataSet_04_018
IGF1 CNOT7 shRNA Liver HepG2 0.0222222 -5.49185 0.21416849862151 0.308076041564963 DataSet_04_051
IGF1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.418825 -1.25558 0.000178074192461669 0.00695506684865238 DataSet_02_14
IGF1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.257107 -1.95956 0.000541067273052911 0.0131324611518885 DataSet_02_34
IGF1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.35616 1.23644 0.0170764271179864 0.393478982766751 DataSet_02_75
IGF1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.384713 -1.37815 0.0263135636011284 0.480607566711255 DataSet_02_45
IGF1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.539482 -0.890353 0.00276722978427185 0.0202483256085572 DataSet_02_35
IGF1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.295325 -1.75962 0.000215843816933208 0.0902604881460443 DataSet_02_32
IGF1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.590651 -0.759623 0.00131411645583577 0.0132636248123832 DataSet_02_47
IGF1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.41048 1.76997 0.0008428835238095 0.0211159026553755 DataSet_04_060
IGF1 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.5894 0.668486 0.149586147895011 0.311385783759676 DataSet_04_064
IGF1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.634361 -0.656623 0.0432026606005706 0.158020689076743 DataSet_04_061
IGF1 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.47682 1.79777 0.000766144167310057 0.295295723370632 DataSet_04_063
IGF1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 2.43805 1.28573 0.033445132094506 0.314903376293669 DataSet_04_065
IGF1 EZH2 shRNA Colon SW480 1.97809 0.98411 - - DataSet_03_298
IGF1 SMARCA4 siRNA Colon HCT116 1.60116 0.679121 4.680221e-01 0.7063878 DataSet_03_302
IGF1 ELF3 knockdown Bile_duct HBDEC2 0.095975 -3.3812 2.115351e-01 3.536958e-01 DataSet_03_305
IGF1 SNAI2 shRNA Pancreas KLM1 0.626622 -0.674333 2.667259e-02 0.23281378 DataSet_03_307
IGF1 BRCA1 siRNA Mammary_gland MCF7 1.9018 0.927367 7.546610e-03 0.7791568 DataSet_03_308
IGF1 EZH2 shRNA Mammary_gland LM2 1.57676 0.656961 8.880693e-01 9.734241e-01 DataSet_03_350
IGF1 PTPN14 CRISPR Brain U5-NPC 2.05556 1.03953 6.816642e-01 0.80085583 DataSet_03_357
IGF1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 4.32619 2.1131 8.973608e-04 5.034987e-02 DataSet_03_359
IGF1 NCOA2 siRNA Uterus endometrial stromal cells 0.448308 -1.15744 0.9383720841 1 DataSet_03_360
IGF1 TP53 knockout Stomach SNU1 2.96019 1.56569 0.2021345648 0.9301241 DataSet_03_365
IGF1 SMARCA2 shRNA Lung NCI-H1944 0.603947 -0.727505 6.709896e-02 4.223604e-01 DataSet_03_377
IGF1 DDX5 shRNA Stomach HGC-27 0.4 -1.32193 - - DataSet_03_379
IGF1 DNMT1 siRNA Skin Human melanoma cells 1.71616 0.77918 3.089924e-01 4.174848e-01 DataSet_03_382
IGF1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.80501 0.852007 0.3644246709 0.8501973 DataSet_03_387
IGF1 NFKBIA shRNA Bone_marrow U2OS 0.001853 -9.07592 6.957089e-01 0.87860055 DataSet_03_389
IGF1 YY1 knockdown Liver HepG2 7 2.80735 1.667463e-04 1.099512e-03 DataSet_03_390
IGF1 KDM5A CRISPR Lung GLC16 0.363232 -1.46104 1.424081e-01 0.260697240 DataSet_03_392
IGF1 ASXL1 CRISPR Embryo iPSC 0.648067 -0.625785 0.3646513698 0.8385590 DataSet_03_394
IGF1 TLE4 CRISPR Lymph CAR T Cell 1.83325 0.874401 8.798655e-03 0.12363102 DataSet_03_398
IGF1 RELA CRISPR Brain T30 0.00176493 -9.14617 0.3240142949 0.8400824 DataSet_03_399
IGF1 HMGA1 shRNA Bile_duct HUCCT1 15 3.90689 3.124218e-03 0.066490550 DataSet_03_400
IGF1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.61516 0.691674 6.844768e-01 0.7816283 DataSet_03_403
IGF1 CDK7 shRNA Bone_marrow D458 33.2 5.05311 1.346415e-03 0.08077410 DataSet_03_404
IGF1 TFAP2A knockout Embryo H9 1.57692 0.657112 3.393464e-01 0.46344409 DataSet_03_405
IGF1 CHD1 shRNA Prostate LNCaP 0.588895 -0.763918 9.996841e-03 2.287079e-01 DataSet_03_407
IGF1 MAP3K7 shRNA Prostate LNCaP 0.662169 -0.594728 1.609504e-02 1.070981e-01 DataSet_03_408
IGF1 E2F2 siRNA Prostate LNCaP 0.407407 -1.29546 7.239481e-02 2.416360e-01 DataSet_03_414
IGF1 BRD4 CRISPR Lymph CD8+ T cells 1.58123 0.661045 - - DataSet_03_420
IGF1 PRDM1 CRISPR Lymph CD8+ T cells 1.52708 0.610772 - - DataSet_03_421
IGF1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 2.95349 1.56242 - - DataSet_03_422
IGF1 USP7 shRNA Skin xenograft cells 0.455301 -1.13511 0.25864862 0.4348960 DataSet_03_431
IGF1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 2.05882 1.04182 - - DataSet_03_432
IGF1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 3.21538 1.68499 5.318943e-01 0.95223609 DataSet_03_439
IGF1 FOSL1 siRNA Prostate MSKPCa3 0.5 -1 0.0965454234 0.4885717 DataSet_03_445
IGF1 RELB CRISPR Colon SW480 3.56098 1.83227 3.396472e-04 1.270473e-02 DataSet_03_449
IGF1 CBX2 siRNA Mammary_gland MCF7 2.1675 1.11603 8.355416e-01 0.9022048492 DataSet_03_451
IGF1 PPARG siRNA Aortic_valve Valvular endothelial cell 1.63739 0.711396 3.462626e-01 7.508584e-01 DataSet_03_456
IGF1 SREBF2 siRNA Umbilical_vein HUVEC 0.36887 -1.43882 3.526585e-04 2.614081e-02 DataSet_03_457
IGF1 HAND1 siRNA Placenta HPMVEC 0.230769 -2.11548 2.046819e-01 0.9463341 DataSet_03_459
IGF1 TXNIP shRNA Cord_Blood CD34+ cells 3.79167 1.92283 - - DataSet_03_461
IGF1 SOX9 knockout Liver HuH7 0.222222 -2.16992 3.238027e-01 4.468470e-01 DataSet_03_463
IGF1 PARP1 knockout Embryo_kidney HEK293a 15 3.90689 4.257771e-02 1.034965e-01 DataSet_03_464
IGF1 LIN28A siRNA Mammary_gland MCF7M 3.15322 1.65683 9.669240e-01 1.0000000 DataSet_03_469
IGF1 LIN28A siRNA Mammary_gland MCF7M 3.15322 1.65683 9.669240e-01 1.0000000 DataSet_03_470
IGF1 EZH2 siRNA Prostate LNCaP 2.16191 1.11231 - - DataSet_03_472
IGF1 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.435685 -1.19864 0.0006075914 0.01231762 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate RBM14 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of IGF1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines