Gene Overview
Target Gene: KCNA2
NCBI Official Symbol: KCNA2
Entrez ID: 3737
Ensembl ID: ENSG00000177301
Gene Full Name: potassium voltage-gated channel subfamily A member 2
Strand: -
Gene Locus: 1p13.3
External Links:

KCNA2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate KCNA2   
T(co)Fs that Repress KCNA2
The Intensity of the Gene Regulated by T(co)Fs:
KCNA2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
KCNA2 FOXO1 shRNA Bone EWS-FLI1 2.20379 1.13999 1.23894e-05 0.00761 DataSet_01_106
KCNA2 ID1 siRNA Lung H1650 1.95808 0.96944 0.17869 0.53432 DataSet_01_118
KCNA2 ZIC2 siRNA Pancreas PANC1 0.45267 -1.14348 - - DataSet_01_121
KCNA2 FOXM1 siRNA Central_nervous_system U87 2.32821 1.21922 - - DataSet_01_122
KCNA2 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.90551 0.93018 0.5658 0.99993 DataSet_01_137
KCNA2 POLR3A siRNA Mammary_gland MCF7 3.2236 1.68867 - - DataSet_01_139
KCNA2 ELK1 siRNA Peripheral_blood CD4+ T cells 0.00001 -17.123 0.43395 0.65624 DataSet_01_162
KCNA2 GATA3 siRNA Peripheral_blood CD4+ T cells 0.00001 -17.1634 0.42654 0.7391 DataSet_01_163
KCNA2 JUN siRNA Peripheral_blood CD4+ T cells 0.00001 -16.9427 0.46208 0.70139 DataSet_01_164
KCNA2 MAF siRNA Peripheral_blood CD4+ T cells 0.00001 -17.0691 0.44163 0.77222 DataSet_01_165
KCNA2 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.00001 -17.0915 0.43727 0.72196 DataSet_01_166
KCNA2 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.00001 -17.2552 0.41263 0.82921 DataSet_01_167
KCNA2 STAT3 siRNA Peripheral_blood CD4+ T cells 0.00001 -16.7446 0.47577 0.99183 DataSet_01_168
KCNA2 HOXB7 siRNA Pancreas Capan-1 0.59679 -0.7447 0.08405 0.56934 DataSet_01_170
KCNA2 TP53 siRNA Lung SAECs 7.92623 2.98663 0.00057 0.11905 DataSet_01_175
KCNA2 GATA2 siRNA Prostate LNCaP 0.59225 -0.75573 0.13798 0.24626 DataSet_01_193
KCNA2 CREB1 shRNA Parotid_gland H3118 MEC 3.53484 1.82164 0.25108 0.61747 DataSet_01_194
KCNA2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.2528 -1.98395 - - DataSet_01_197
KCNA2 TP63 siRNA Head_and_neck SCC-1 2.51497 1.33054 - - DataSet_01_198
KCNA2 TP63 siRNA Immortalized_keratinocyte HaCaT 1.50161 0.58651 - - DataSet_01_200
KCNA2 TP63 siRNA Head_and_neck SCC-012 0.5618 -0.83188 - - DataSet_01_201
KCNA2 TP63 siRNA Head_and_neck SCC-6 2.05988 1.04256 - - DataSet_01_202
KCNA2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 5.66386 2.50178 - - DataSet_01_208
KCNA2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.05482 1.03901 - - DataSet_01_209
KCNA2 TWIST1 shRNA Stomach CAF14 1.68315 0.75116 0.12103 0.99996 DataSet_01_252
KCNA2 FOXO3 siRNA Pancreas PANC1 4.49809 2.16931 - - DataSet_01_267
KCNA2 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.71371 1.44026 0.0248 0.78744 DataSet_01_290
KCNA2 POSTN shRNA Brain GSC272 3.14763 1.65426 0.0319 0.52483 DataSet_01_293
KCNA2 TFAP4 siRNA Brain BE(2)-C 0.17799 -2.49011 0.32796 0.51625 DataSet_01_295
KCNA2 PTEN shRNA Lung HCC827 0.54584 -0.87345 0.17606 0.65772 DataSet_01_302
KCNA2 PTEN shRNA Mammary_gland SKBR3 2.25518 1.17324 0.66689 0.8914 DataSet_01_303
KCNA2 SOX9 siRNA Prostate VCaP 0.57806 -0.79071 0.02324 0.9316 DataSet_01_308
KCNA2 SOX9 siRNA Prostate VCaP 0.57806 -0.79071 0.02324 0.9316 DataSet_01_309
KCNA2 HOXC6 siRNA Prostate LNCaP 3.2931 1.71945 0.49989 0.99927 DataSet_01_333
KCNA2 GATA3 siRNA Oral_cavity OEC-M1 1.74224 0.80094 0.16408 0.99787 DataSet_01_347
KCNA2 ATF4 siRNA Skin A375 0.621524 -0.686118 0.139501355359314 0.775512819201899 DataSet_03_018
KCNA2 BCL6 siRNA Lymph Pfeiffer DLBCL 1.77265 0.825908 0.393684570356441 0.793931772310368 DataSet_03_026
KCNA2 CEBPB siRNA Embryo hESC 1.88149 0.911873 0.0335165341080153 0.317342363081273 DataSet_03_049
KCNA2 FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.641279 -0.640976 0.00203459549183272 0.119697166783097 DataSet_03_078
KCNA2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 1.58245 0.662159 - - DataSet_03_096
KCNA2 GATA2 siRNA Uterus Decidual stromal cells 1.93227 0.950294 0.15250143513029 0.772326303542354 DataSet_03_100
KCNA2 GATA4 siRNA Stomach AGS 0.449897 -1.15233 0.159007872098249 0.808297960178345 DataSet_03_105
KCNA2 HNF4a siRNA Liver HepG2 0.487603 -1.03622 0.38853273508756 0.878787161737542 DataSet_03_126
KCNA2 MTA2 siRNA Stomach SGC-7901 1.69062 0.757556 - - DataSet_03_169
KCNA2 MYC siRNA Central_nervous_system DAOY M2.1 1.75312 0.809929 8.96392087521862e-06 4.55665977823613e-05 DataSet_03_178
KCNA2 PHB shRNA Embryo Embryonic stem cells (ESCs) 1.6657 0.736126 0.141067196807152 0.252965398050587 DataSet_03_211
KCNA2 PRRX1 CRISPR Neuroblastoma 691-MES 0.521398 -0.939543 0.0888432203754804 0.89189998148014 DataSet_03_217
KCNA2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.18705 -2.4185 - - DataSet_03_246
KCNA2 STAT3 CRISPR Embryo hESC 8.12577 3.0225 0.00778798455386493 0.0586430004260948 DataSet_03_258
KCNA2 STAT6 siRNA Umbilical_vein HUVEC 0.518519 -0.947533 0.0496064725224231 0.719345554770036 DataSet_03_264
KCNA2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.33333 2.41504 0.371703139966147 0.728122078749542 DataSet_02_75
KCNA2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.625544150875026 0.907192271244138 DataSet_02_49
KCNA2 CNOT3 shRNA Lung A549 3.30279 1.72369 7.643510e-03 0.8278603 DataSet_03_340
KCNA2 EZH2 shRNA Colon SW480 2.90246 1.53728 - - DataSet_03_298
KCNA2 BRCA1 siRNA Mammary_gland MCF7 1.74619 0.80421 3.554823e-01 0.9999931 DataSet_03_308
KCNA2 TET1 CRISPR Mammary_gland MDA-MB-231 21.394 4.41913 6.061369e-01 7.601920e-01 DataSet_03_347
KCNA2 TET1 CRISPR Mammary_gland Hs578T 0.225218 -2.1506 4.501887e-01 6.380033e-01 DataSet_03_355
KCNA2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 2.55383 1.35266 3.324294e-02 2.114827e-01 DataSet_03_359
KCNA2 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.83944 0.879271 8.302996e-07 2.789706e-05 DataSet_03_362
KCNA2 MYC siRNA Peripheral_blood T lymphocyte 1.93978 0.955893 4.914554e-01 0.720746895 DataSet_03_363
KCNA2 TP53 knockout Stomach SNU1 1.52333 0.607225 0.7723221989 0.9951793 DataSet_03_365
KCNA2 TPR shRNA Bone_marrow U2OS 2.345 1.22959 1.345509e-05 2.048629e-03 DataSet_03_370
KCNA2 DDX5 shRNA Stomach HGC-27 17.3333 4.11548 - - DataSet_03_379
KCNA2 DNMT1 siRNA Skin Human melanoma cells 0.587814 -0.766569 3.557110e-05 2.519162e-04 DataSet_03_382
KCNA2 NFKBIA shRNA Bone_marrow U2OS 0.315084 -1.66619 5.215378e-01 0.87005461 DataSet_03_389
KCNA2 ILF2 siRNA Stomach SGC-7901 0.125 -3 0.1724160165 0.35128987 DataSet_03_393
KCNA2 TLE4 CRISPR Lymph CAR T Cell 1.88373 0.91359 1.316865e-01 0.41839584 DataSet_03_398
KCNA2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 0.21875 -2.19265 5.852023e-02 0.3239928 DataSet_03_403
KCNA2 SATB2 CRISPR Colon Colon organoid 2.75 1.45943 3.817294e-01 0.95735254 DataSet_03_406
KCNA2 MAP3K7 shRNA Prostate LNCaP 0.25 -2 1.976246e-03 3.047744e-02 DataSet_03_408
KCNA2 E2F1 siRNA Prostate LNCaP 2 1 5.300378e-01 0.8184360010 DataSet_03_413
KCNA2 PRDM1 CRISPR Lymph CD8+ T cells 0.507752 -0.977804 - - DataSet_03_421
KCNA2 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.341709 -1.54916 - - DataSet_03_422
KCNA2 USP7 shRNA Skin xenograft cells 0.509524 -0.972779 0.26461110 0.4348960 DataSet_03_431
KCNA2 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.660644 -0.598054 1.859267e-01 0.543109037 DataSet_03_434
KCNA2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.5 -1 4.145000e-01 0.90558273 DataSet_03_439
KCNA2 CAMTA1 knockout Embryo_kidney HEK293T 3.77778 1.91754 5.786771e-03 0.09759725 DataSet_03_448
KCNA2 RELB CRISPR Colon SW480 2.39759 1.26159 4.751195e-03 5.181711e-02 DataSet_03_449
KCNA2 CBX2 siRNA Mammary_gland MCF7 1.84729 0.885413 8.174582e-01 0.8916211371 DataSet_03_451
KCNA2 ZFP36L1 CRISPR Lung NCI-H1876 1.74623 0.804243 9.772142e-01 0.999274054 DataSet_03_454
KCNA2 ARID1A shRNA Bile_duct MMNK1 2.20202 1.13883 5.785728e-01 0.755836209 DataSet_03_458
KCNA2 HAND1 siRNA Placenta HPMVEC 0.321429 -1.63743 1.296320e-01 0.9463341 DataSet_03_459
KCNA2 SMARCA1 Cas13 Embryo_kidney HEK293T 0.533333 -0.906891 - - DataSet_03_466
KCNA2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.53333 1.34104 - - DataSet_03_467
KCNA2 SMARCA1 shRNA Embryo_kidney HEK293T 0.3 -1.73697 - - DataSet_03_468
KCNA2 CREBBP CRISPR Lymph U2932 2.33333 1.22239 1.843990e-01 1.0000000 DataSet_03_474
Regulation Region
 
T(co)Fs that significantly regulate NFATC3 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of KCNA2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines