Gene Overview
| Target Gene: | Krt8 |
| NCBI Official Symbol: | Krt8 |
| Entrez ID: | 16691 |
| Ensembl ID: | ENSMUSG00000049382 |
| Gene Full Name: | keratin 8 |
| Strand: | - |
| Gene Locus: | 15 F2|15 57.2 cM |
| External Links: |
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Krt8 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Krt8
T(co)Fs
that Repress Krt8
The Intensity of the Gene Regulated by T(co)Fs:
Krt8-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Krt8 | Adnp | knockout | Embryo | Whole embryonic body | 2.86319 | 1.51762 | 0.019055817564427 | 0.343505491448377 | DataSet_11_001 |
| Krt8 | Arid1a | knockout | Ovary | Ovary | 0.665327 | -0.587865 | 0.0311852205588373 | 0.94648870498129 | DataSet_11_005 |
| Krt8 | Cbx2 | knockout | Gonads | Embryonic gonads | 0.371714 | -1.42774 | 5.0704170664336e-10 | 7.79003854628883e-08 | DataSet_11_018 |
| Krt8 | Ets2 | siRNA | Embryo | Trophoblast stem (TS) cells | 2.40712 | 1.26731 | 1.28888926522309e-07 | 0.0026477307420516 | DataSet_11_040 |
| Krt8 | Foxp1 | knockout | Eye | Lens | 0.453505 | -1.14081 | - | - | DataSet_11_044 |
| Krt8 | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 2.2036 | 1.13987 | 0.10117527470981 | 0.987135756219234 | DataSet_11_048 |
| Krt8 | Hsf4 | knockout | Eye | Lens | 0.410755 | -1.28365 | 0.230116064746898 | 0.987999303842427 | DataSet_11_058 |
| Krt8 | Irf6 | knockout | Skin | Skin | 0.415718 | -1.26632 | 0.00144157925348368 | 0.0555620574945964 | DataSet_11_062 |
| Krt8 | Lhx8 | knockout | Ovary | Ovary | 2.63297 | 1.39669 | 0.00253650623965002 | 0.0261245927954151 | DataSet_11_070 |
| Krt8 | Lmx1b | knockout | Kidney | Kidney | 1.73366 | 0.793821 | 0.00840276431005426 | 0.172747150775846 | DataSet_11_072 |
| Krt8 | Meis1 | knockout | Hematopoietic | KSL hematopoietic cells | 1.7388 | 0.798092 | 0.12031239934717 | 0.995635220774426 | DataSet_11_081 |
| Krt8 | Nrf1 | knockdown | Liver | Liver | 3.65437 | 1.86962 | 0.00317432794057979 | 0.032010780080341 | DataSet_11_096 |
| Krt8 | Otx2 | knockout | Eye | Retina | 1.62654 | 0.701811 | 0.618692231882963 | 0.999923528647439 | DataSet_11_097 |
| Krt8 | p63 | siRNA | Skin | Primary keratinocytes | 5.22744 | 2.3861 | 2.71454855535262e-06 | 0.000235858075479405 | DataSet_11_099 |
| Krt8 | Pitx2 | knockout | Eye | Cornea | 0.553078 | -0.854445 | 0.285474751781657 | 0.680110606452178 | DataSet_11_103 |
| Krt8 | Prdm14 | knockout | Embryo | ES cells | 0.633194 | -0.65928 | 7.33634916331002e-06 | 0.000178704559131703 | DataSet_11_107 |
| Krt8 | Rest | knockout | Brain | Brain | 2.6146 | 1.38659 | 0.150133574360931 | 1 | DataSet_11_113 |
| Krt8 | Runx1 | knockout | Embryo | Embryo | 0.623201 | -0.68223 | 0.847116056184984 | 0.999961610631375 | DataSet_11_114 |
| Krt8 | Runx1 | knockout | Bone_marrow | KSL cells | 0.387569 | -1.36747 | 0.0122441136873302 | 0.501816143669732 | DataSet_11_115 |
| Krt8 | Runx1 | knockout | Lymph | ProB cells | 0.503065 | -0.991184 | 0.483749198176295 | 0.794180108497105 | DataSet_11_116 |
| Krt8 | Runx2 | knockout | Humeri | Embryonic humeri | 2.13333 | 1.09311 | 0.178352254284213 | 0.998727525190751 | DataSet_11_118 |
| Krt8 | Smad1 | knockout | Lung | Lung left lobe | 0.654474 | -0.611591 | 0.110234450954325 | 0.542998753027287 | DataSet_11_126 |
| Krt8 | Smad4 | knockout | Aorta | Aortic arteries | 5.0827 | 2.34559 | 0.216124069783634 | 0.637623251588213 | DataSet_11_128 |
| Krt8 | Snai1 | knockout | Embryo | Teratoma | 0.515631 | -0.955589 | - | - | DataSet_11_130 |
| Krt8 | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 1.70684 | 0.771329 | 0.124550398433711 | 0.409592486747043 | DataSet_11_131 |
| Krt8 | Sohlh2 | knockout | Ovary | Ovary | 0.631053 | -0.664167 | 4.53773488762882e-05 | 0.000698857747686353 | DataSet_11_135 |
| Krt8 | Sox11 | knockout | Eye | Retina | 1.80645 | 0.853159 | - | - | DataSet_11_137 |
| Krt8 | Sox17 | siRNA | Embryo | NG4 | 1.57325 | 0.653752 | 0.173255158998175 | 0.532862182727092 | DataSet_11_139 |
| Krt8 | Sox2 | siRNA | Embryo | NG4 | 8.88482 | 3.15134 | 8.72582098516706e-05 | 0.0127486701647007 | DataSet_11_141 |
| Krt8 | Sp3 | knockout | Heart | Heart | 0.639681 | -0.644575 | 0.0126874804719157 | 0.580168587033292 | DataSet_11_145 |
| Krt8 | Tet2 | shRNA | Embryo | ES cells | 0.392406 | -1.34958 | - | - | DataSet_11_161 |
| Krt8 | Tsc22d4 | shRNA | Liver | Liver | 0.305461 | -1.71094 | 0.000322743417265839 | 0.00387007174748708 | DataSet_11_169 |
| Krt8 | Vdr | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.473474 | -1.07864 | 0.150152980453783 | 0.999827445128963 | DataSet_11_174 |
| Krt8 | Yy1 | knockout | Muscle | Skeletal muscle | 2.44762 | 1.29138 | 2.39777696739536e-05 | 0.000409371967541217 | DataSet_11_182 |
| Krt8 | Yy1 | knockout | White_adipose_tissue | Subcutaneous white adipose tissue | 0.232826 | -2.10268 | 0.461531519962383 | 0.83719621483665 | DataSet_11_184 |
| Krt8 | Yy1 | knockout | White_adipose_tissue | Visceral white adipose tissue | 0.154383 | -2.69541 | 0.028678976937857 | 0.129020747818809 | DataSet_11_185 |
| Krt8 | Kdm5b | knockout | Heart | left ventricles | 0.539316 | -0.890796 | 0.5120016731 | 0.9999827 | DataSet_11_210 |
| Krt8 | Tet1 | shRNA | Embryo | ES cells | 0.380502 | -1.39402 | 9.887659e-09 | 3.470928e-06 | DataSet_11_211 |
| Krt8 | Tet1 | shRNA | Embryo | ES cells | 0.380502 | -1.39402 | 9.887659e-09 | 3.470928e-06 | DataSet_11_212 |
| Krt8 | Tet1 | shRNA | Embryo | ES cells | 7.59541 | 2.92513 | 1.414822e-04 | 0.03324113 | DataSet_11_213 |
| Krt8 | Tet1 | shRNA | Embryo | ES cells | 7.59541 | 2.92513 | 1.414822e-04 | 0.03324113 | DataSet_11_214 |
| Krt8 | Tet1 | shRNA | Embryo | ES cells | 2.00093 | 1.00067 | 4.986850e-01 | 0.94047830 | DataSet_11_191 |
| Krt8 | Tet1 | knockout | Embryo | ES cells | 1.55901 | 0.640632 | 1.735692e-02 | 0.17247242 | DataSet_11_216 |
| Krt8 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 127.736 | 6.99702 | 4.436746e-08 | 8.150892e-05 | DataSet_11_192 |
| Krt8 | Ezh1 | knockout | Muscle | LSK | 1.69937 | 0.765 | 0.0142412881 | 0.07165320 | DataSet_11_233 |
| Krt8 | Ncoa3 | shRNA | Embryo | ES cells | 2.59466 | 1.37555 | 1.254499e-12 | 2.978855e-10 | DataSet_11_194 |
| Krt8 | Ncoa3 | shRNA | Embryo | ES cells | 2.59466 | 1.37555 | 1.254499e-12 | 2.978855e-10 | DataSet_11_195 |
| Krt8 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 88.4232 | 6.46635 | - | - | DataSet_11_196 |
| Krt8 | Ezh2 | knockdown | Brain | Brain | 0.658207 | -0.603387 | 1.161094e-01 | 0.4100423957 | DataSet_11_221 |
| Krt8 | Dnmt3b | knockout | Heart | Cardiac ventricle | 2.31811 | 1.21295 | 3.353305e-07 | 4.705145e-04 | DataSet_11_205 |
| Krt8 | Smarca4 | shRNA | Embryo | ES cells | 0.184135 | -2.44116 | - | - | DataSet_11_224 |
| Krt8 | Smarca4 | shRNA | Embryo | ES cells | 0.184135 | -2.44116 | - | - | DataSet_11_225 |
| Krt8 | Dnmt3a | knockout | Skeletal_muscle | Satellite cells | 2.78846 | 1.47947 | 1.490911e-03 | 1.0000000 | DataSet_11_208 |
| Krt8 | Dux | siRNA | Embryo | ES cells | 1.65572 | 0.727456 | 9.575066e-02 | 0.8584025050 | DataSet_11_239 |
| Krt8 | Dnmt3a | siRNA | Embryo | iPSC | 2.47324 | 1.3064 | - | - | DataSet_11_241 |
| Krt8 | Lin28a | knockout | Heart | Heart | 0.26051 | -1.94059 | 0.1189998555 | 0.8777652 | DataSet_11_243 |
| Krt8 | Twist1 | knockout | Bone_marrow | stromal cells | 1.10026e-18 | -59.6569 | - | - | DataSet_11_244 |
| Krt8 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 0.581006 | -0.783376 | 6.270999e-02 | 0.3355973244 | DataSet_11_245 |
| Krt8 | Ezh2 | knockout | Calvaria | calvaria | 5.75 | 2.52356 | 3.429304e-02 | 0.46193852 | DataSet_11_247 |
| Krt8 | Dnmt1 | siRNA | Embryo | Embryo | 0.403226 | -1.31034 | - | - | DataSet_11_248 |
| Krt8 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 0.05 | -4.32193 | 6.186044e-03 | 3.330056e-02 | DataSet_11_250 |
| Krt8 | Crebbp | shRNA | Lung | preSC | 0.382127 | -1.38788 | 1.229269e-03 | 0.11862672 | DataSet_11_255 |
| Krt8 | Eed | knockout | Spinal_cord | spinal cord | 0.580973 | -0.783456 | 9.360497e-01 | 9.999790e-01 | DataSet_11_261 |
| Krt8 | Fubp1 | shRNA | Bone_marrow | BM cells | 4 | 2 | 1.313765e-01 | 0.692309451 | DataSet_11_262 |
| Krt8 | Bcl3 | knockout | Bone | Osteoblast | 0.6 | -0.736966 | 8.749743e-02 | 7.519931e-01 | DataSet_11_263 |
| Krt8 | Ctnnb1 | knockout | Embryo | MGE cells | 2.82243 | 1.49694 | 2.177553e-01 | 0.536773832 | DataSet_11_266 |
| Krt8 | Dux | knockout | Embryo | Embryo | 1.82578 | 0.868511 | 6.536659e-01 | 7.775224e-01 | DataSet_11_269 |
| Krt8 | Mef2d | CRISPR | Heart | Cardiac ventricle | 1.89156 | 0.919573 | 6.240096e-01 | 0.8015205970 | DataSet_11_270 |
| Krt8 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.285749 | -1.80718 | 1.421549e-01 | 0.81420760 | DataSet_11_272 |
| Krt8 | Dux | knockout | Embryo | Embryo | 1.82578 | 0.868511 | 6.536658e-01 | 7.775367e-01 | DataSet_11_273 |
| Krt8 | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 0.32 | -1.64386 | 2.434555e-02 | 1.735149e-01 | DataSet_11_276 |
| Krt8 | Usp7 | knockout | Embryo | ES cells | 0.591973 | -0.756396 | 5.885293e-02 | 0.4500830 | DataSet_11_279 |
| Krt8 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 0.158739 | -2.65527 | 3.164965e-02 | 0.5395938 | DataSet_11_284 |
| Krt8 | Pdx1 | CRISPR | Liver | Liver | 0.527182 | -0.923626 | 3.961073e-02 | 0.347196746 | DataSet_11_286 |
| Krt8 | Usp7 | siRNA | Embryo | ES cells | 0.498555 | -1.00418 | 1.884339e-01 | 0.6667924 | DataSet_11_287 |
| Krt8 | Kmt2d | CRISPR | Liver | MA1L | 0.594707 | -0.749749 | 1.311893e-02 | 8.065522e-02 | DataSet_11_290 |
| Krt8 | Kmt2d | CRISPR | Liver | MA1L | 0.607838 | -0.718242 | 1.409462e-02 | 8.219547e-02 | DataSet_11_291 |
| Krt8 | Irf8 | knockout | Brain | mice brain | 0.621409 | -0.686385 | 5.671987e-01 | 9.221196e-01 | DataSet_11_292 |
| Krt8 | Tfap2a | knockout | Brain | Brain | 0.35514 | -1.49354 | 0.3192223557 | 0.9599640 | DataSet_11_295 |
| Krt8 | Hmg20a | siRNA | Hypothalamus | Primary hypothalamic astrocytes | 0.395349 | -1.3388 | 0.1220621320 | 0.3707471 | DataSet_11_300 |
| Krt8 | Arid2 | knockout | Muscle | LSK | 0.559322 | -0.838249 | 1.223264e-01 | 1.000000e+00 | DataSet_11_301 |
| Krt8 | Dnmt1 | knockout | Skin | Keratinocytes | 10.0933 | 3.33533 | 2.678996e-04 | 0.0140849265 | DataSet_11_303 |
| Krt8 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 1.69231 | 0.758992 | - | - | DataSet_11_306 |
| Krt8 | Esr1 | knockout | Liver | Liver | 1.5121 | 0.596555 | 7.716248e-02 | 1.0000000 | DataSet_11_307 |
| Krt8 | Tbx20 | knockdown | Heart | primary cardiac fibroblasts | 0.142857 | -2.80735 | 2.475826e-02 | 0.78959479 | DataSet_11_309 |
| Krt8 | Suz12 | knockout | Lung | Alveolar macrophage | 2.66 | 1.41143 | 1.154456e-01 | 1.897975e-01 | DataSet_11_312 |
| Krt8 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 3.80952 | 1.92961 | - | - | DataSet_11_313 |
| Krt8 | Actl6a | knockout | Nerve | sciatic nerve | 5.59375 | 2.48382 | 6.224485e-03 | 0.113640940 | DataSet_11_314 |
| Krt8 | Ahr | knockout | Liver | Liver | 2.321 | 1.21474 | 2.013116e-02 | 0.3245111952 | DataSet_11_315 |
| Krt8 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 0.228571 | -2.12928 | 5.758301e-02 | 0.3236190112 | DataSet_11_317 |
| Krt8 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 1.99651 | 0.997477 | 4.309537e-03 | 5.776613e-02 | DataSet_11_320 |
| Krt8 | Gata2 | knockout | Brain | Pituitary gland | 1.57807 | 0.658164 | 0.405465605 | 1.0000000 | DataSet_11_322 |
| Krt8 | Dnmt3l | knockout | Testis | Spermatogonial progenitor cells | 6.87387 | 2.78112 | - | - | DataSet_11_328 |
| Krt8 | Dnmt3a | knockout | Brain | Cortex | 2.57951 | 1.3671 | 2.149987e-01 | 0.8157709 | DataSet_11_330 |
| Krt8 | Kdm5b | siRNA | Embryo | ES cells | 0.510679 | -0.96951 | 0.1122890973 | 0.8933528 | DataSet_11_331 |
| Krt8 | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 0.444444 | -1.16992 | 2.712043e-01 | 5.859160e-01 | DataSet_11_332 |
| Krt8 | Ezh2 | knockout | Eye | Retina | 0.00799738 | -6.96626 | 0.3159541048 | 1.0000000 | DataSet_11_334 |
| Krt8 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 0.418528 | -1.25661 | - | - | DataSet_11_336 |
| Krt8 | Gtf2ird1 | knockout | Lip | Lip | 0.616197 | -0.698536 | 6.582664e-02 | 4.112643e-01 | DataSet_11_339 |
| Krt8 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.253703 | -1.97879 | 1.836689e-03 | 0.009790412 | DataSet_11_340 |
| Krt8 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 3.01542 | 1.59236 | 0.0663371666 | 0.1712697 | DataSet_11_341 |
| Krt8 | Hnrnpk | siRNA | Embryo | ES cells | 1.82675 | 0.869275 | 8.399243e-03 | 0.024287312 | DataSet_11_342 |
| Krt8 | Dnmt1 | knockout | Kidney | kidney Cap Mesenchyme | 3.30829 | 1.72609 | 1.140091e-01 | 3.534006e-01 | DataSet_11_344 |
| Krt8 | Gata4 | CRISPR | Heart | primary cardiac fibroblasts | 0.142857 | -2.80735 | 2.475826e-02 | 0.78959479 | DataSet_11_347 |
Regulation Region
Expression Atlas of Krt8