Gene Overview
Target Gene: LUM
NCBI Official Symbol: LUM
Entrez ID: 4060
Ensembl ID: ENSG00000139329
Gene Full Name: lumican
Strand: -
Gene Locus: 12q21.33
External Links:

LUM Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LUM   
T(co)Fs that Repress LUM
The Intensity of the Gene Regulated by T(co)Fs:
LUM-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LUM SPDEF shRNA Mammary_gland MCF7 0.45963 -1.12147 0.89368 0.99999 DataSet_01_107
LUM ARID1A shRNA Ovary OSE4 0.41331 -1.2747 - - DataSet_01_108
LUM ARID1A shRNA Ovary IOSE80pc 0.53411 -0.9048 - - DataSet_01_109
LUM GABPA siRNA Lung A549 2.91357 1.54279 8.10463e-10 6.22669e-08 DataSet_01_113
LUM ID1 siRNA Lung A549 2.02145 1.01539 0.00269 0.10315 DataSet_01_117
LUM ZIC2 siRNA Pancreas PANC1 0.13179 -2.92365 - - DataSet_01_121
LUM FOXM1 siRNA Central_nervous_system U87 8.45815 3.08034 - - DataSet_01_122
LUM ID1 shRNA Neuroepithelium GSC8 0.66172 -0.59571 0.00048 0.00065 DataSet_01_134
LUM POLR3A siRNA Mammary_gland MCF7 0.55433 -0.85117 - - DataSet_01_139
LUM SOX4 shRNA Parotid_gland ACC3 0.28513 -1.81032 0.08658 0.94842 DataSet_01_140
LUM TFAP2C shRNA Mammary_gland MCF7 1.96337 0.97333 2.99544e-10 6.44903e-09 DataSet_01_150
LUM TEAD4 shRNA Stomach SNU216 0.55952 -0.83773 - - DataSet_01_151
LUM HSF1 shRNA Skin A375 1.56777 0.64871 1.68444e-07 2.16842e-05 DataSet_01_155
LUM GABPA shRNA Prostate C4-2B 1528.31 10.5777 0.23846 0.43934 DataSet_01_190
LUM GABPA shRNA Prostate LNCaP 985.239 9.94433 0.46399 0.7048 DataSet_01_191
LUM GATA2 siRNA Prostate LNCaP 0.26552 -1.91309 0.00541 0.02151 DataSet_01_193
LUM CREB1 shRNA Parotid_gland H3118 MEC 0.36654 -1.44797 0.01649 0.21733 DataSet_01_194
LUM CREB1 shRNA Parotid_gland HSY 0.63675 -0.6512 0.39598 0.97459 DataSet_01_195
LUM TP63 siRNA Immortalized_keratinocyte HaCaT RG 2.55556 1.35364 - - DataSet_01_196
LUM TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.45513 -1.13566 - - DataSet_01_197
LUM TP63 siRNA Head_and_neck SCC-1 0.5 -1 - - DataSet_01_198
LUM TP63 siRNA Head_and_neck SCC-1 2.3668 1.24293 - - DataSet_01_199
LUM FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.18441 1.12724 - - DataSet_01_208
LUM FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.85306 0.88991 - - DataSet_01_209
LUM LIN28A siRNA Embryo H9 0.36537 -1.45257 0.00179 0.01752 DataSet_01_215
LUM ERG siRNA Prostate VCaP 1.94622 0.96067 2.35887e-06 0.00037 DataSet_01_216
LUM ATM shRNA Mammary_gland MCF10A 0.53303 -0.90772 5.24836e-09 4.14297e-07 DataSet_01_219
LUM KLF9 siRNA Liver HepG2 0.63263 -0.66057 5.25958e-08 2.32964e-06 DataSet_01_222
LUM KLF2 shRNA Bone_marrow RPMI8226 0.45366 -1.14031 0.62047 0.93593 DataSet_01_226
LUM IRX1 shRNA Bone_marrow 143B 0.16436 -2.6051 0.10096 0.32479 DataSet_01_227
LUM FOXP1 siRNA Prostate LNCaP 1.7194 0.7819 0.09872 0.50232 DataSet_01_234
LUM NFYB siRNA Bone_marrow U2OS ER-HA-E2F1 0.66149 -0.5962 0.00271 0.05042 DataSet_01_238
LUM SMAD3 siRNA Liver Hep3B 1.67834 0.74703 - - DataSet_01_249
LUM SMAD4 siRNA Liver Hep3B 1.52334 0.60724 - - DataSet_01_250
LUM TWIST1 shRNA Stomach CAF32 3.50109 1.80781 0.00017 0.01362 DataSet_01_253
LUM TWIST1 shRNA Stomach CAF 1.69673 0.76276 0.71904 0.92339 DataSet_01_254
LUM OTX2 siRNA Brain Neural precursor cells 1.52203 0.606 0.00566 0.33435 DataSet_01_268
LUM AR shRNA Prostate CWR22Pc 2.14825 1.10316 0.05014 0.17137 DataSet_01_278
LUM STAT5 shRNA Prostate CWR22Pc 2.06417 1.04556 0.0531 0.15601 DataSet_01_279
LUM ESRRA shRNA Embryo_kidney 293T 0.29312 -1.77042 0.01485 0.58596 DataSet_01_280
LUM ZIC5 siRNA Skin A375 0.1485 -2.75149 - - DataSet_01_284
LUM ZIC5 siRNA Skin SK-MEL-28 0.57052 -0.80964 - - DataSet_01_285
LUM SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 7.63331 2.93231 0.17982 0.89686 DataSet_01_290
LUM POSTN shRNA Brain GSC272 2.66123 1.4121 0.24241 0.61911 DataSet_01_293
LUM TFAP4 siRNA Brain BE(2)-C 0.65099 -0.6193 0.75725 0.76115 DataSet_01_295
LUM SOX7 siRNA Umbilical_vein HUVEC 3.63915 1.8636 0.01357 0.89788 DataSet_01_299
LUM SOX17 siRNA Umbilical_vein HUVEC 0.47129 -1.0853 0.13292 0.99998 DataSet_01_300
LUM PTEN shRNA Skin A431 0.10966 -3.18893 0.00074 0.0655 DataSet_01_301
LUM PTEN shRNA Lung HCC827 4.08835 2.03152 0.09509 0.59889 DataSet_01_302
LUM PTEN shRNA Mammary_gland SKBR3 3.50784 1.81058 0.33006 0.74381 DataSet_01_303
LUM SOX9 siRNA Prostate VCaP 3.19902 1.67763 0.10227 0.9316 DataSet_01_308
LUM SOX9 siRNA Prostate VCaP 3.19902 1.67763 0.10227 0.9316 DataSet_01_309
LUM OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.64211 -0.63911 0.22852 0.447 DataSet_01_313
LUM ELK3 shRNA Mammary_gland MDA-MB-231 8.1565 3.02795 3.06386e-06 6.29103e-05 DataSet_01_318
LUM ZNF25 siRNA Bone_marrow hMSC-TERT4 1.83786 0.87802 0.09018 0.58773 DataSet_01_319
LUM HOXC6 siRNA Prostate LNCaP 0.07487 -3.73954 0.13647 0.99927 DataSet_01_333
LUM REST siRNA Skin NHEK 0.63723 -0.65012 0.05762 0.75583 DataSet_01_338
LUM KLF7 siRNA Embryo HCE 2.10769 1.07566 0.00365 0.6419 DataSet_01_340
LUM ETV4 shRNA Prostate PC3 0.29225 -1.77474 - - DataSet_01_356
LUM SOX17 siRNA Umbilical_vein HUVEC 0.32759 -1.61003 - - DataSet_01_360
LUM GTF2B siRNA Cervix HeLa 1.65768 0.72916 - - DataSet_01_362
LUM AR siRNA Prostate abl cells 1.97521 0.982004 0.658304224055134 0.999852161656754 DataSet_03_004
LUM AR siRNA Prostate LNCaP 1.55758 0.639302 0.404576869477389 1 DataSet_03_005
LUM AR siRNA Prostate VCaP 1.53338 0.616711 0.000394989524712413 0.0110743447086382 DataSet_03_007
LUM ARID1A siRNA Mammary_gland MDA-MB-157 0.639676 -0.644587 - - DataSet_03_014
LUM ARID2 CRISPR Liver JHH4 1.50283 0.587684 0.583765387950368 1 DataSet_03_015
LUM ASCL1 siRNA Lung DMS79 7.75 2.9542 0.188732116143592 0.828013100186986 DataSet_03_016
LUM BCL6 siRNA Lymph Pfeiffer DLBCL 0.473268 -1.07927 0.290877602871553 0.738860856676454 DataSet_03_026
LUM CASP8AP2 siRNA Bone_marrow U2OS 0.591802 -0.756814 0.0415191432168118 0.22553961500529 DataSet_03_031
LUM CEBPB siRNA Embryo hESC 0.609651 -0.713945 0.046667635240049 0.363041219461956 DataSet_03_049
LUM FOXA1 siRNA Prostate LNCaP 0.294133 -1.76546 3.06295855547523e-11 2.61564408803363e-08 DataSet_03_083
LUM GATA4 siRNA Stomach AGS 1.60339 0.681125 0.0320994942012266 0.612165148938791 DataSet_03_105
LUM GATA4 siRNA Stomach YCC3 1.9093 0.933047 0.10072541215418 0.646128706007691 DataSet_03_107
LUM GATA6 siRNA Stomach AGS 2.09761 1.06875 0.00369808277556527 0.200451121583001 DataSet_03_108
LUM GATA6 siRNA Stomach KatoIII 0.453227 -1.1417 0.000462716854100938 0.135345466809919 DataSet_03_109
LUM HINFP siRNA Bone_marrow U2OS 0.650232 -0.620974 0.0910110584171019 0.274646069094554 DataSet_03_123
LUM HNF4a siRNA Liver HepG2 2.26066 1.17675 0.0456129540516316 0.631197383555721 DataSet_03_126
LUM IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.67872 0.747361 0.120595501643292 0.995169730223505 DataSet_03_134
LUM JARID1A siRNA Brain NB1691 1.56368 0.644947 0.111572491026299 0.643576369913548 DataSet_03_136
LUM KLF5 siRNA Stomach KatoIII 0.313181 -1.67493 0.000907967327934352 0.0954467596428078 DataSet_03_150
LUM KLF5 siRNA Stomach YCC3 0.279589 -1.83862 0.0150212873012939 0.19666624940116 DataSet_03_151
LUM MEF2D shRNA Liver HuH7 1.63384 0.70827 - - DataSet_03_162
LUM MITF siRNA Skin SK-MEL-5 0.475397 -1.0728 3.22817217417652e-06 3.85901335297197e-05 DataSet_03_168
LUM MTA2 siRNA Stomach SGC-7901 0.361359 -1.46849 - - DataSet_03_169
LUM MYB siRNA Cord_Blood CD34+ progenitor cells 3.26641 1.70771 - - DataSet_03_170
LUM MYCN siRNA Brain NB1691 0.588177 -0.765677 0.0916286158842547 0.611825062509504 DataSet_03_186
LUM MYCN siRNA Brain BE(2)C cells 0.445563 -1.1663 - - DataSet_03_188
LUM NPAT siRNA Bone_marrow U2OS 0.499053 -1.00274 0.00470037959345039 0.0496793311514487 DataSet_03_201
LUM PHB shRNA Embryo Embryonic stem cells (ESCs) 1.75307 0.809883 0.235633719414978 0.373929957051982 DataSet_03_211
LUM SOX11 siRNA Lung_fibroblast NHLF 2.044 1.0314 0.00855342783829594 0.304507242190339 DataSet_03_237
LUM SOX11 siRNA Lung_fibroblast NHLF 2.58001 1.36738 0.07775176214448 0.393973245856743 DataSet_03_238
LUM SOX2 siRNA Lung LK2 1.66612 0.736491 - - DataSet_03_241
LUM SOX2 siRNA Embryo NTera-2 1.66669 0.736987 0.00195847413456671 0.051743900438978 DataSet_03_243
LUM SOX2 CRISPR Seminoma-like TCam-2 1.59753 0.675842 0.166339159396002 0.999580851453413 DataSet_03_244
LUM SOX2 siRNA Mammary_gland GSC-11 0.430321 -1.21652 4.72800089117012e-05 0.00487497619977204 DataSet_03_245
LUM SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.284483 -1.81359 - - DataSet_03_246
LUM SP1 siRNA Ovary OVSAYO 0.528844 -0.919087 0.0098338119170198 0.131845180956703 DataSet_03_251
LUM SSRP1 siRNA Brain BE(2)C cells 2.29342 1.1975 0.00306572718778628 0.186360145638726 DataSet_03_255
LUM STAT3 CRISPR Embryo hESC 0.461597 -1.11529 0.173895320031048 0.241658284908357 DataSet_03_258
LUM STAT6 siRNA Umbilical_vein HUVEC 3.47893 1.79864 0.0271562296368808 0.633886357852553 DataSet_03_264
LUM TFAP2C siRNA Mammary_gland MCF7 1.50448 0.589269 0.146225223321441 0.502546708300074 DataSet_03_274
LUM TFE3 siRNA Kidney UOK257-2 0.42826 -1.22344 - - DataSet_03_275
LUM TWIST1 siRNA Bone_marrow MSCs 2.22994 1.157 - - DataSet_03_283
LUM ZHX2 shRNA Kidney 786-O 0.518573 -0.947383 6.55495600822695e-06 0.00172363146751351 DataSet_03_287
LUM DNMT1 siRNA Lung_fibroblast IMR-90 1.63121 0.705946 6.186026e-02 0.9999458 DataSet_03_317
LUM NFKBIZ knockout Colon Colon organoid 0.448736 -1.15606 3.705869e-01 0.752866043 DataSet_03_323
LUM AEBP1 siRNA Umbilical_vein HUVEC 0.523776 -0.932978 5.276760e-01 0.999982779 DataSet_03_300
LUM ELF3 CRISPR Bile_duct HBDEC2 4.31193 2.10833 2.196989e-03 1.102303e-02 DataSet_03_304
LUM SNAI2 shRNA Pancreas KLM1 2.60308 1.38022 3.122251e-01 0.66661906 DataSet_03_307
LUM ACTR5 siRNA Muscle RD 1.74636 0.80435 - - DataSet_03_343
LUM INO80 siRNA Muscle RD 0.165399 -2.59598 - - DataSet_03_344
LUM DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 2.7933 1.48197 3.063314e-01 8.051171e-01 DataSet_03_311
LUM TET1 CRISPR Mammary_gland MDA-MB-231 0.420368 -1.25028 5.366312e-02 1.791906e-01 DataSet_03_347
LUM EZH2 shRNA Mammary_gland LM2 1.65023 0.722664 8.772085e-02 4.130123e-01 DataSet_03_350
LUM SKI CRISPR Blood HL60 2.32143 1.21501 9.356145e-03 0.181881273 DataSet_03_351
LUM ESR1 siRNA Mammary_gland MCF7 2.01693 1.01216 4.234522e-02 0.1678817389 DataSet_03_352
LUM TET1 CRISPR Mammary_gland Hs578T 1.89097 0.919126 3.380251e-03 2.400958e-02 DataSet_03_355
LUM CREBBP CRISPR Brain U5-NPC 22.3182 4.48015 0.0159785570 0.7490853 DataSet_03_356
LUM PTPN14 CRISPR Brain U5-NPC 4.06818 2.02438 2.280936e-01 0.44948245 DataSet_03_357
LUM TP53 CRISPR Brain U5-NPC 12.1818 3.60666 5.634108e-06 2.193660e-02 DataSet_03_358
LUM ABL1 shRNA Liver HuH7 2.0809 1.05721 2.048994e-04 0.0023590141 DataSet_03_367
LUM USP22 shRNA Liver PLC_PRF_5 cells 0.544304 -0.877516 6.479623e-01 0.79695155 DataSet_03_368
LUM DNMT3A knockout Embryo_kidney HEK293T 2.01361 1.00979 - - DataSet_03_369
LUM BHLHE40 shRNA Cervix HeLaS3 0.538462 -0.893085 3.091609e-01 0.84602735 DataSet_03_372
LUM GLI1 siRNA Skeletal_muscle RMS13 2.02971 1.02128 2.531588e-03 0.034651674 DataSet_03_375
LUM ZNF213 siRNA Mammary_gland MCF7 0.130282 -2.94029 1.752378e-01 6.592819e-01 DataSet_03_376
LUM SMARCA2 shRNA Lung NCI-H1944 2.40492 1.26599 1.927256e-01 5.966899e-01 DataSet_03_377
LUM EZH2 CRISPR Ovary SKOV3 5.2 2.37851 6.092271e-03 0.0570681366 DataSet_03_378
LUM NFKB2 siRNA Bone_marrow U2OS 0.303023 -1.7225 3.243386e-03 0.08673476 DataSet_03_381
LUM DNMT1 siRNA Skin Human melanoma cells 2.77901 1.47457 5.700217e-01 6.731579e-01 DataSet_03_382
LUM TCF19 CRISPR Oral_squamous CAL27 0.229363 -2.1243 1.327748e-04 0.0071319428 DataSet_03_383
LUM YY1 shRNA Brain GSC1517 0.472973 -1.08017 - - DataSet_03_384
LUM YY1 shRNA Brain GSC23 0.62701 -0.673441 - - DataSet_03_385
LUM YY1 shRNA Brain GSC3028 0.5625 -0.830075 - - DataSet_03_386
LUM TRIM8 siRNA Mammary_gland MCF7 0.571429 -0.807355 7.438169e-01 0.8512334390 DataSet_03_388
LUM ASXL1 CRISPR Embryo iPSC 5.155 2.36597 0.0473761554 0.8048302 DataSet_03_394
LUM RELA CRISPR Brain T30 1.7611 0.816476 0.3469407583 0.8400824 DataSet_03_399
LUM HMGA1 shRNA Bile_duct HUCCT1 0.228748 -2.12817 7.056183e-03 0.101777148 DataSet_03_400
LUM SUMO1 CRISPR Bone_marrow U2OS 0.529206 -0.918098 1.975129e-03 2.101840e-02 DataSet_03_401
LUM EHF shRNA Stomach MKN7 2.38371 1.25321 - - DataSet_03_402
LUM JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.55907 0.640685 3.543455e-02 0.3239928 DataSet_03_403
LUM CDK7 shRNA Bone_marrow D458 1.61002 0.687077 1.381465e-01 0.46231672 DataSet_03_404
LUM TFAP2A knockout Embryo H9 1.50072 0.585654 5.497983e-02 0.15331015 DataSet_03_405
LUM SATB2 CRISPR Colon Colon organoid 1.7 0.765535 8.468471e-02 0.95735254 DataSet_03_406
LUM CHD1 shRNA Prostate LNCaP 3.89333 1.96101 2.173756e-06 1.304616e-03 DataSet_03_407
LUM STRAP knockout Nerve SK-N-AS 0.0445841 -4.48733 - - DataSet_03_409
LUM USP22 shRNA Liver HuH7 6.54024 2.70934 - - DataSet_03_411
LUM FOXK2 shRNA Ovary OVCAR-5 1.6 0.678072 3.675316e-01 0.48808418 DataSet_03_419
LUM STAT5B CRISPR Embryo_kidney HEK293 2.33333 1.22239 6.235202e-01 0.873720406 DataSet_03_424
LUM LHX2 shRNA Bone_marrow ES-derived RPE cells 0.518868 -0.946561 3.503384e-02 1.000000e+00 DataSet_03_428
LUM USP7 shRNA Skin xenograft cells 0.48807 -1.03484 0.27044945 0.4348960 DataSet_03_431
LUM EP300 knockout Pancreas HPAF-II orthotopic cells 0.43987 -1.18485 3.003546e-01 5.105329e-01 DataSet_03_436
LUM CIC knockout Brain Immortalized Astrocyte Cells 0.121622 -3.03953 6.762799e-02 4.398942e-01 DataSet_03_438
LUM FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.66594 0.736332 9.800063e-01 1.00000000 DataSet_03_439
LUM HMG20A siRNA Mammary_gland MDA-MB-231 2.22917 1.1565 0.1091504051 0.3429368 DataSet_03_442
LUM PURA siRNA Cervix HeLa 2.625 1.39232 1.050501e-02 0.096651968 DataSet_03_444
LUM CAMTA1 knockout Embryo_kidney HEK293T 0.5 -1 7.289713e-01 0.81166952 DataSet_03_448
LUM CBX2 siRNA Mammary_gland MCF7 13.291 3.73237 1.298148e-03 0.0066809172 DataSet_03_451
LUM OGT siRNA Embryo BeWo cells 2 1 7.297592e-01 0.90946370 DataSet_03_453
LUM ZFP36L1 CRISPR Lung NCI-H1876 1.78027 0.832099 5.234239e-02 0.856007401 DataSet_03_454
LUM PPARG siRNA Aortic_valve Valvular endothelial cell 2.2894 1.19497 1.230815e-01 5.423246e-01 DataSet_03_456
LUM SREBF2 siRNA Umbilical_vein HUVEC 1.85346 0.890222 6.924524e-01 9.193963e-01 DataSet_03_457
LUM ARID1A shRNA Bile_duct MMNK1 0.0269659 -5.21272 2.094979e-05 0.006940231 DataSet_03_458
LUM IRF2 shRNA Cord_Blood CD34+ cells 0.375 -1.41504 - - DataSet_03_460
LUM TXNIP shRNA Cord_blood ST3 0.269231 -1.89309 2.099051e-02 0.2102006535 DataSet_03_462
LUM SOX9 knockout Liver HuH7 0.158129 -2.66082 1.712507e-04 2.906758e-03 DataSet_03_463
LUM PARP1 knockout Embryo_kidney HEK293a 1.8254 0.86821 3.929423e-03 1.458939e-02 DataSet_03_464
LUM STAT3 shRNA Liver HepG2 8 3 4.858909e-03 0.0957783407 DataSet_03_465
LUM SMARCA1 Cas13 Embryo_kidney HEK293T 1.66667 0.736966 - - DataSet_03_466
LUM SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 4 2 - - DataSet_03_467
LUM SMARCA1 shRNA Embryo_kidney HEK293T 2 1 - - DataSet_03_468
LUM LIN28A siRNA Mammary_gland MCF7M 1.57675 0.656951 4.967028e-01 0.8335262 DataSet_03_469
LUM LIN28A siRNA Mammary_gland MCF7M 1.57675 0.656951 4.967028e-01 0.8335262 DataSet_03_470
LUM WHSC1 siRNA Prostate PC3 1.96154 0.971986 2.196666e-01 0.46027201 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LUM
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines