Gene Overview
Target Gene: MS4A4A
NCBI Official Symbol: MS4A4A
Entrez ID: 51338
Ensembl ID: ENSG00000110079
Gene Full Name: membrane spanning 4-domains A4A
Strand: +
Gene Locus: 11q12.2
External Links:

MS4A4A Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MS4A4A   
T(co)Fs that Repress MS4A4A
The Intensity of the Gene Regulated by T(co)Fs:
MS4A4A-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MS4A4A SPDEF shRNA Mammary_gland MCF7 2.08909 1.06287 0.84145 0.99999 DataSet_01_107
MS4A4A ZIC2 siRNA Pancreas PANC1 1.70479 0.76959 - - DataSet_01_121
MS4A4A FOXM1 siRNA Central_nervous_system U87 2.00227 1.00163 - - DataSet_01_122
MS4A4A ZNF254 siRNA Gastrointestinal_tissue GIST-T1 0.5524 -0.85623 0.02673 0.10405 DataSet_01_127
MS4A4A ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.94854 0.9624 0.01556 0.05212 DataSet_01_128
MS4A4A POLR3A siRNA Mammary_gland MCF7 1.58929 0.66838 - - DataSet_01_139
MS4A4A HSF1 shRNA Skin A375 1.61475 0.69131 0.09868 0.29912 DataSet_01_155
MS4A4A HOXB7 siRNA Pancreas MIA PaCa-2 0.54852 -0.86637 0.06387 0.61989 DataSet_01_169
MS4A4A GABPA shRNA Prostate C4-2B 599.943 9.22868 0.23432 0.43934 DataSet_01_190
MS4A4A GABPA shRNA Prostate LNCaP 288.966 8.17476 0.46283 0.7048 DataSet_01_191
MS4A4A CREB1 shRNA Parotid_gland H3118 MEC 2.50349 1.32394 0.91903 0.97223 DataSet_01_194
MS4A4A TP63 siRNA Immortalized_keratinocyte HaCaT RG 17.9 4.16189 - - DataSet_01_196
MS4A4A HIC1 shRNA Mammary_gland HBL100 0.53363 -0.90609 - - DataSet_01_205
MS4A4A FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.50674 -0.98069 - - DataSet_01_208
MS4A4A REST siRNA Prostate LNCaP 1.63457 0.70891 0.11507 0.38082 DataSet_01_211
MS4A4A LIN28A siRNA Embryo H9 2.41443 1.27168 0.00376 0.02739 DataSet_01_215
MS4A4A TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.37787 -1.40404 0.00074 0.01245 DataSet_01_217
MS4A4A NFYB siRNA Bone_marrow U2OS ER-HA-E2F1 1.52502 0.60883 0.34982 0.77019 DataSet_01_238
MS4A4A STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.2005 -2.31833 1.54783e-06 2e-04 DataSet_01_239
MS4A4A TWIST1 shRNA Stomach CAF14 1.54 0.62293 0.2588 0.99996 DataSet_01_252
MS4A4A TWIST1 shRNA Stomach CAF32 1.93066 0.94909 0.32852 0.48802 DataSet_01_253
MS4A4A TWIST1 shRNA Stomach CAF 1.7243 0.78601 0.12775 0.61574 DataSet_01_254
MS4A4A FOXO3 siRNA Pancreas PANC1 1.53109 0.61456 - - DataSet_01_267
MS4A4A SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.85823 0.89393 0.29188 0.90406 DataSet_01_290
MS4A4A TFAP4 siRNA Brain BE(2)-C 0.13779 -2.85942 0.28664 0.51625 DataSet_01_295
MS4A4A SOX7 siRNA Umbilical_vein HUVEC 9.98653 3.31998 0.17468 0.89788 DataSet_01_299
MS4A4A SOX17 siRNA Umbilical_vein HUVEC 5.86206 2.55141 0.04861 0.99998 DataSet_01_300
MS4A4A PTEN shRNA Lung HCC827 0.63317 -0.65933 0.32702 0.74044 DataSet_01_302
MS4A4A SOX9 siRNA Prostate VCaP 2.10194 1.07172 0.07887 0.9316 DataSet_01_308
MS4A4A SOX9 siRNA Prostate VCaP 2.10194 1.07172 0.07887 0.9316 DataSet_01_309
MS4A4A MYC siRNA Colon HCT116 1.76705 0.82134 0.11576 0.16504 DataSet_01_324
MS4A4A HOXC6 siRNA Prostate LNCaP 0.06618 -3.91754 0.001 0.9106 DataSet_01_333
MS4A4A TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.26804 -1.89947 0.08172 0.34493 DataSet_02_129
MS4A4A PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.36701 -1.44611 0.00314 0.03121 DataSet_02_131
MS4A4A SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.63711 -0.65038 0.03329 0.13264 DataSet_02_134
MS4A4A PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.58969 -0.76197 0.14071 0.37086 DataSet_02_137
MS4A4A RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.35077 -1.51141 0.00741 0.44546 DataSet_02_139
MS4A4A RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 0.58763 -0.76702 0.09934 0.30391 DataSet_02_141
MS4A4A RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.48387 -1.04731 0.04127 0.08724 DataSet_02_143
MS4A4A PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.42657 -1.22913 0.08164 0.29165 DataSet_02_144
MS4A4A FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.42017 -1.25096 0.00772 0.08537 DataSet_02_147
MS4A4A ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.36308 -1.46165 0.00132 0.2373 DataSet_02_148
MS4A4A RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.83007 0.34601 0.53609 DataSet_02_151
MS4A4A ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6378 -0.64883 0.1763 0.47724 DataSet_02_152
MS4A4A YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53231 -0.90967 0.00513 0.41577 DataSet_02_153
MS4A4A PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.5487 0.63106 0.0085 0.08073 DataSet_02_158
MS4A4A HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 1.65287 0.72497 0.11254 0.27595 DataSet_02_160
MS4A4A AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.57358 -0.80194 0.02319 0.53443 DataSet_02_162
MS4A4A U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.64362 -0.63573 0.03712 0.18384 DataSet_02_165
MS4A4A RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 0.51241 -0.96463 0.00971 0.17801 DataSet_02_166
MS4A4A EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.59536 -0.74817 0.0313 0.23057 DataSet_02_167
MS4A4A U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.59397 -0.75153 0.04452 0.12756 DataSet_02_170
MS4A4A RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.71986 0.78229 0.02248 0.2135 DataSet_02_171
MS4A4A CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 1.795 0.84398 0.29037 1 DataSet_02_176
MS4A4A CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 1.97917 0.98489 0.20773 1 DataSet_02_185
MS4A4A CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.44 1.28688 0.65489 1 DataSet_02_187
MS4A4A RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.57639 0.65662 0.94007 1 DataSet_02_190
MS4A4A UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 1.57377 0.65423 0.66498 1 DataSet_02_198
MS4A4A ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 0.56 -0.8365 0.0695 1 DataSet_02_203
MS4A4A ARID1A siRNA Mammary_gland MDA-MB-157 3.19065 1.67385 - - DataSet_03_014
MS4A4A ASCL1 siRNA Lung DMS79 1.94444 0.959358 0.0409581380502087 0.646808950312483 DataSet_03_016
MS4A4A ATF4 siRNA Skin A375 0.56063 -0.83488 0.0677026159659266 0.775512819201899 DataSet_03_018
MS4A4A BCL6 siRNA Lymph Pfeiffer DLBCL 0.646007 -0.630377 0.338780277980337 0.765941813363676 DataSet_03_026
MS4A4A CEBPB siRNA Embryo hESC 1.77695 0.829405 0.997834484213852 0.999415292917901 DataSet_03_049
MS4A4A GATA2 siRNA Uterus Decidual stromal cells 1.72567 0.78716 0.0779835552818536 0.700992095545108 DataSet_03_100
MS4A4A GATA4 siRNA Stomach KatoIII 0.596124 -0.746317 0.237427037138819 0.914908611202096 DataSet_03_106
MS4A4A GATA6 siRNA Stomach AGS 1.56439 0.645601 0.427622637300742 0.833873769540529 DataSet_03_108
MS4A4A HIC1 CRISPR Prostate PC3 1.93283 0.950714 - - DataSet_03_118
MS4A4A HNF4a siRNA Liver HepG2 1.74427 0.802627 0.192358730453992 0.793347729704853 DataSet_03_126
MS4A4A MEF2D shRNA Liver HuH7 1.69122 0.758065 - - DataSet_03_162
MS4A4A MYB siRNA Cord_Blood CD34+ progenitor cells 2.87681 1.52447 - - DataSet_03_170
MS4A4A NR2F2 siRNA Uterus Primary eutopic stromal cells 0.599801 -0.737444 0.0921842041566405 0.99947668859931 DataSet_03_202
MS4A4A PHB shRNA Embryo Embryonic stem cells (ESCs) 1.68641 0.753959 0.240735420440531 0.379882352957786 DataSet_03_211
MS4A4A SOX2 siRNA Mammary_gland GSC-11 1.53375 0.617064 0.0879033764305133 0.281851846393202 DataSet_03_245
MS4A4A STAT6 siRNA Umbilical_vein HUVEC 1.92672 0.94615 0.311328961595083 0.876741320594925 DataSet_03_264
MS4A4A TFE3 siRNA Kidney UOK257-2 0.486486 -1.03953 - - DataSet_03_275
MS4A4A ZNF746 siRNA Colon HCT116 0.615999 -0.699 - - DataSet_03_293
MS4A4A CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.475807 -1.07155 0.00210203551719846 0.0219421918313695 DataSet_04_004
MS4A4A FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.513514 -0.961526 0.0221020293593958 0.0884798824661244 DataSet_04_010
MS4A4A MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.27572 -1.85872 0.0111458231049878 0.0320150890382864 DataSet_04_012
MS4A4A NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 125.122 6.96719 0.175724851353002 0.311630868014623 DataSet_04_014
MS4A4A NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.245885 -2.02395 0.00191554358069903 0.0163746447695341 DataSet_04_015
MS4A4A ANXA2 CRISPR Liver HepG2 0.643766 -0.635392 0.0187388147634067 0.586260907069394 DataSet_04_024
MS4A4A ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.642424 -0.638402 0.0130057683635684 0.0861955128584968 DataSet_04_048
MS4A4A HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.88889 1.53051 0.4339685708292 0.770023768447679 DataSet_02_75
MS4A4A SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.40909 2.43539 0.0235016917713924 0.0693542396943344 DataSet_02_47
MS4A4A SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.44 -1.18442 0.535703504318037 0.859109520286393 DataSet_02_49
MS4A4A TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.81818 1.49476 0.450763539104818 0.638620306217992 DataSet_02_43
MS4A4A TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.95455 0.966833 0.249529275986005 0.415019022491734 DataSet_02_53
MS4A4A ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.559459 -0.837894 0.0265209999543227 0.0900136541200619 DataSet_04_060
MS4A4A CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.351562 -1.50815 0.00296046833815552 0.0441763862554782 DataSet_04_064
MS4A4A DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.326172 -1.6163 0.000597732030733049 0.295295723370632 DataSet_04_063
MS4A4A HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.395062 -1.33985 0.00140882635912231 0.00846361088682529 DataSet_04_059
MS4A4A SMARCA4 siRNA Colon HCT116 1.61495 0.69149 4.568200e-01 0.7039399 DataSet_03_302
MS4A4A SNAI2 shRNA Pancreas KLM1 0.536329 -0.898809 3.415764e-02 0.25632994 DataSet_03_307
MS4A4A BRCA1 siRNA Mammary_gland MCF7 1.81359 0.858852 6.189640e-03 0.7791568 DataSet_03_308
MS4A4A TET1 CRISPR Mammary_gland MDA-MB-231 13.2879 3.73204 3.631252e-01 5.809509e-01 DataSet_03_347
MS4A4A SKI CRISPR Blood HL60 0.378601 -1.40125 1.335247e-02 0.216634883 DataSet_03_351
MS4A4A RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 3.45295 1.78783 1.424073e-02 1.617510e-01 DataSet_03_359
MS4A4A ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.586212 -0.770506 4.124973e-01 5.213702e-01 DataSet_03_362
MS4A4A E2F1 siRNA Nasopharynx HK1 0.1875 -2.41504 1.095759e-01 5.574194e-01 DataSet_03_373
MS4A4A EZH2 CRISPR Ovary SKOV3 2 1 7.222732e-01 0.8315380784 DataSet_03_378
MS4A4A NFKB2 siRNA Bone_marrow U2OS 0.625 -0.678072 6.485529e-01 0.83078621 DataSet_03_381
MS4A4A NFKBIA shRNA Bone_marrow U2OS 0.0106635 -6.55117 5.647932e-01 0.87005461 DataSet_03_389
MS4A4A ILF2 siRNA Stomach SGC-7901 2.08333 1.05889 0.9087579678 0.94075476 DataSet_03_393
MS4A4A IKZF2 CRISPR Lymph CAR T Cell 0.362474 -1.46405 3.395938e-01 0.759688072 DataSet_03_397
MS4A4A TLE4 CRISPR Lymph CAR T Cell 1.90079 0.926598 6.422476e-01 0.86055280 DataSet_03_398
MS4A4A EHF shRNA Stomach MKN7 0.357214 -1.48514 - - DataSet_03_402
MS4A4A JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 4 2 8.945167e-03 0.3239928 DataSet_03_403
MS4A4A PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.485348 -1.04291 - - DataSet_03_432
MS4A4A CIC knockout Brain Immortalized Astrocyte Cells 3.08333 1.62449 1.695397e-01 6.421568e-01 DataSet_03_438
MS4A4A OGT siRNA Embryo BeWo cells 0.5 -1 7.297592e-01 0.90946370 DataSet_03_453
MS4A4A SREBF2 siRNA Umbilical_vein HUVEC 0.108576 -3.20322 4.304158e-02 3.362333e-01 DataSet_03_457
MS4A4A IRF2 shRNA Cord_Blood CD34+ cells 2.04545 1.03242 - - DataSet_03_460
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MS4A4A
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines