Gene Overview
| Target Gene: | Pitx3 |
| NCBI Official Symbol: | Pitx3 |
| Entrez ID: | 18742 |
| Ensembl ID: | ENSMUSG00000025229 |
| Gene Full Name: | paired-like homeodomain transcription factor 3 |
| Strand: | - |
| Gene Locus: | 19 C3|19 38.75 cM |
| External Links: |
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Pitx3 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Pitx3
T(co)Fs
that Repress Pitx3
The Intensity of the Gene Regulated by T(co)Fs:
Pitx3-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Pitx3 | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 0.617701 | -0.69502 | 0.273002422515376 | 0.654877428055621 | DataSet_11_013 |
| Pitx3 | Bhlha9 | knockout | Limb | Whole limb bud | 1.86083 | 0.895943 | - | - | DataSet_11_016 |
| Pitx3 | Dmrt1 | knockout | Testis | Juvenile testes | 1.79382 | 0.843036 | 0.514337817628732 | 0.886942208967735 | DataSet_11_025 |
| Pitx3 | Dmrt1 | knockout | Testis | Juvenile testes | 1.61208 | 0.688922 | 0.196656700332743 | 0.830739734023206 | DataSet_11_028 |
| Pitx3 | Erg | knockdown | Bone_marrow | HSPCs | 0.583345 | -0.777579 | 0.121242780470763 | 0.88026135071672 | DataSet_11_038 |
| Pitx3 | Gfi1 | knockout | Cord_Blood | T-cells | 0.596522 | -0.745353 | 0.068051519080044 | 0.4284484985943 | DataSet_11_053 |
| Pitx3 | Klf17 | shRNA | Mammary_gland | 168FARN | 0.5735 | -0.802135 | 0.206630654877334 | 0.325185522754323 | DataSet_11_066 |
| Pitx3 | Lhx8 | knockout | Ovary | Ovary | 2.53107 | 1.33975 | 0.152888457918815 | 0.295421977426321 | DataSet_11_070 |
| Pitx3 | Mafg | knockout | Embryo | Whole embryo | 0.48686 | -1.03842 | 0.315253112907972 | 1 | DataSet_11_073 |
| Pitx3 | Neurod1 | knockout | Eye | Retina | 2.32313 | 1.21607 | 0.272273808800884 | 0.471461612326431 | DataSet_11_088 |
| Pitx3 | Neurod1 | knockout | Eye | Pineal gland | 0.635075 | -0.655002 | 0.182588291494093 | 0.9983937273602 | DataSet_11_089 |
| Pitx3 | Nhlh2 | knockout | Eye | Retina | 0.603473 | -0.728638 | 0.244166469155604 | 0.523726874680013 | DataSet_11_092 |
| Pitx3 | Nr2f2 | knockout | Ovary | E14.5 Ovary | 1.80908 | 0.855258 | 0.0848165881920239 | 0.834975080343504 | DataSet_11_094 |
| Pitx3 | Nr2f2 | knockout | Ovary | E16.5 Ovary | 0.569515 | -0.812194 | 0.212938709961924 | 0.601968990062371 | DataSet_11_095 |
| Pitx3 | Pax6 | knockout | Embryo | Surface ectoderm | 0.500057 | -0.999837 | 0.00267185678143364 | 0.29386227962082 | DataSet_11_101 |
| Pitx3 | Pitx2 | knockout | Eye | Cornea | 0.285736 | -1.80725 | 0.00235905469118902 | 0.0799313798247557 | DataSet_11_103 |
| Pitx3 | Pparg | siRNA | Adipose_tissue | Preadipocytes | 0.519835 | -0.943873 | 0.00530534056034919 | 0.1391709483601 | DataSet_11_105 |
| Pitx3 | Runx1 | knockout | Mammary_gland | Luminal epithelial cells | 0.572454 | -0.804769 | 0.304436001200882 | 0.999784944667092 | DataSet_11_117 |
| Pitx3 | Sall1 | knockout | Kidney | Kidney | 0.609235 | -0.71493 | 0.371395908484678 | 0.996168498532493 | DataSet_11_122 |
| Pitx3 | Smad1 | knockout | Lung | Lung left lobe | 1.53175 | 0.615178 | 0.173826160411056 | 0.542998753027287 | DataSet_11_126 |
| Pitx3 | Smad4 | siRNA | Brain | bEnd3 | 0.461093 | -1.11687 | - | - | DataSet_11_127 |
| Pitx3 | Sp3 | knockout | Heart | Heart | 2.3739 | 1.24726 | 0.01762736699714 | 0.621784385863404 | DataSet_11_145 |
| Pitx3 | Spdef | knockout | Colon | Colon | 0.664382 | -0.589916 | 0.838189718225436 | 0.998614723164469 | DataSet_11_146 |
| Pitx3 | Stat4 | knockout | Lymph | Lamina propria lymphocytes | 3.03085 | 1.59972 | 0.0276852907451848 | 0.765277861379985 | DataSet_11_152 |
| Pitx3 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.437455 | -1.19279 | 0.0123054875264008 | 0.0529738723090658 | DataSet_11_153 |
| Pitx3 | Tbx1 | knockout | Ear | Otic vesicles | 3.01804 | 1.59361 | 0.351055279016838 | 0.996209135879357 | DataSet_11_154 |
| Pitx3 | Wt1 | siRNA | Embryo_kidney | LB-22 | 1.59276 | 0.671527 | 0.267531384072168 | 0.516542191903351 | DataSet_11_179 |
| Pitx3 | Pogz | knockdown | Liver | fetal liver | 0.48928 | -1.03127 | 1.060832e-01 | 0.4147653 | DataSet_11_188 |
| Pitx3 | Dnmt3a | knockout | Skeletal_muscle | Satellite cells | 0.553655 | -0.852942 | 1.580952e-01 | 1.0000000 | DataSet_11_208 |
| Pitx3 | Ncl | siRNA | Embryo | ES cells | 0.625 | -0.678072 | 2.057916e-01 | 0.5468259977 | DataSet_11_240 |
| Pitx3 | Dnmt3a | siRNA | Embryo | iPSC | 2.16149 | 1.11202 | - | - | DataSet_11_241 |
| Pitx3 | Dnmt3b | siRNA | Embryo | iPSC | 2.50256 | 1.3234 | - | - | DataSet_11_242 |
| Pitx3 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 1.55556 | 0.63743 | 2.587649e-01 | 0.6509229770 | DataSet_11_245 |
| Pitx3 | Ezh2 | knockout | Calvaria | calvaria | 0.5 | -1 | 1.504827e-01 | 0.51798464 | DataSet_11_247 |
| Pitx3 | Mecp2 | knockout | Adipose_tissue | brown adipose tissue | 3.12309 | 1.64297 | 3.648021e-03 | 0.119123045 | DataSet_11_253 |
| Pitx3 | Mecp2 | knockout | Adipose_tissue | inguinal adipose tissue | 3.26049 | 1.70509 | 6.466860e-02 | 0.2644457 | DataSet_11_254 |
| Pitx3 | Eed | knockout | Brain | Forebrain | 3.26841 | 1.70859 | 1.161431e-02 | 2.870562e-01 | DataSet_11_258 |
| Pitx3 | Eed | knockout | Brain | hindbrain | 4.61748 | 2.2071 | 2.827756e-04 | 5.764485e-02 | DataSet_11_259 |
| Pitx3 | Eed | knockout | Brain | midbrain | 0.577735 | -0.79152 | 8.468161e-01 | 9.998784e-01 | DataSet_11_260 |
| Pitx3 | Eed | knockout | Spinal_cord | spinal cord | 0.596268 | -0.745967 | 8.877989e-01 | 9.999790e-01 | DataSet_11_261 |
| Pitx3 | Fubp1 | shRNA | Bone_marrow | BM cells | 3 | 1.58496 | 3.730147e-01 | 0.846117121 | DataSet_11_262 |
| Pitx3 | Ctnnb1 | knockout | Embryo | MGE cells | 5.52115 | 2.46497 | 5.722211e-02 | 0.257452218 | DataSet_11_266 |
| Pitx3 | Mef2d | CRISPR | Heart | Cardiac ventricle | 1.5551 | 0.637004 | 6.822653e-02 | 0.2716493684 | DataSet_11_270 |
| Pitx3 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.321616 | -1.63659 | 5.238996e-02 | 0.68454873 | DataSet_11_272 |
| Pitx3 | Ssrp1 | CRISPR | Embryo | ES cells | 2.45455 | 1.29546 | 1.065451e-01 | 0.7762809 | DataSet_11_278 |
| Pitx3 | Pcgf6 | knockout | Liver | Liver | 1.55054 | 0.63277 | 4.952916e-01 | 0.9710425 | DataSet_11_281 |
| Pitx3 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 0.333333 | -1.58496 | 3.813846e-01 | 0.6936949 | DataSet_11_283 |
| Pitx3 | Med19 | knockout | White_adipose_tissue | Gonadal white adipose tissue | 0.169027 | -2.56467 | 8.205728e-02 | 3.717338e-01 | DataSet_11_289 |
| Pitx3 | Setd1a | shRNA | Eye | Retina | 0.621672 | -0.685774 | 3.462462e-01 | 0.5783193022 | DataSet_11_293 |
| Pitx3 | Ssrp1 | CRISPR | Embryo | ES cells | 3.5 | 1.80736 | 7.736098e-02 | 0.33042941 | DataSet_11_296 |
| Pitx3 | Brpf1 | shRNA | Nerve | Neural progenitor cells | 0.653776 | -0.613131 | 8.278392e-01 | 0.9999903 | DataSet_11_299 |
| Pitx3 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.654762 | -0.610958 | - | - | DataSet_11_305 |
| Pitx3 | Esr1 | knockout | Liver | Liver | 2.33333 | 1.22239 | 5.100868e-01 | 1.0000000 | DataSet_11_307 |
| Pitx3 | Cited2 | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 0.428571 | -1.22239 | - | - | DataSet_11_308 |
| Pitx3 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 31.6642 | 4.98478 | 1.019856e-04 | 0.01472294 | DataSet_11_310 |
| Pitx3 | Actl6a | knockout | Nerve | sciatic nerve | 1.80328 | 0.850622 | 5.063251e-01 | 0.706239599 | DataSet_11_314 |
| Pitx3 | Setdb1 | shRNA | Neuron | NE-4C | 0.256065 | -1.96542 | - | - | DataSet_11_323 |
| Pitx3 | Prmt1 | siRNA | Adipose_tissue | 3T3-L1 cells | 11 | 3.45943 | 9.919271e-03 | 0.9832045 | DataSet_11_325 |
| Pitx3 | Snai1 | knockdown | Heart | Heart | 1.77243 | 0.825732 | 1.960884e-03 | 0.03279055 | DataSet_11_326 |
| Pitx3 | Dnmt3l | knockout | Testis | Spermatogonial progenitor cells | 4.35464 | 2.12256 | - | - | DataSet_11_328 |
| Pitx3 | Ezh2 | knockout | Eye | Retina | 0.258621 | -1.95109 | 4.563394e-06 | 4.354572e-04 | DataSet_11_333 |
| Pitx3 | Atrx | knockout | Embryo | ES cells | 2 | 1 | - | - | DataSet_11_335 |
| Pitx3 | Gtf2ird1 | knockout | Lip | Lip | 0.531343 | -0.912284 | 2.403280e-02 | 3.019754e-01 | DataSet_11_339 |
| Pitx3 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.266667 | -1.90689 | 2.984789e-02 | 0.066574108 | DataSet_11_340 |
| Pitx3 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 0.00126103 | -9.63118 | 0.0882140513 | 0.1719706 | DataSet_11_341 |
| Pitx3 | Hnrnpk | siRNA | Embryo | ES cells | 0.422766 | -1.24207 | 2.841778e-02 | 0.059193938 | DataSet_11_342 |
| Pitx3 | Dux | shRNA | Embryo | ES cells | 2 | 1 | 3.612627e-01 | 7.534384e-01 | DataSet_11_345 |
Regulation Region
Expression Atlas of Pitx3