Gene Overview
Target Gene: TWIST2
NCBI Official Symbol: TWIST2
Entrez ID: 117581
Ensembl ID: ENSG00000233608
Gene Full Name: twist family bHLH transcription factor 2
Strand: +
Gene Locus: 2q37.3
External Links:

TWIST2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate TWIST2   
T(co)Fs that Repress TWIST2
The Intensity of the Gene Regulated by T(co)Fs:
TWIST2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
TWIST2 HNF1B shRNA Ovary RMG2 2.01906 1.01368 0.01568 0.03681 DataSet_01_103
TWIST2 ID1 siRNA Lung H1650 0.66312 -0.59266 0.02188 0.33555 DataSet_01_118
TWIST2 ZIC2 siRNA Pancreas PANC1 2.34872 1.23187 - - DataSet_01_121
TWIST2 FOXM1 siRNA Central_nervous_system U87 0.46901 -1.09231 - - DataSet_01_122
TWIST2 HOXB7 siRNA Pancreas MIA PaCa-2 3.53554 1.82193 0.02449 0.59755 DataSet_01_169
TWIST2 GABPA shRNA Prostate C4-2B 1495.84 10.5467 0.23959 0.43934 DataSet_01_190
TWIST2 GABPA shRNA Prostate LNCaP 1149.66 10.167 0.4601 0.7048 DataSet_01_191
TWIST2 TP63 siRNA Head_and_neck SCC-6 1.5335 0.61683 - - DataSet_01_202
TWIST2 XBP1 shRNA Mammary_gland MDA-MB-231 1.63861 0.71247 0.00026 0.00883 DataSet_01_204
TWIST2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.38175 1.25202 - - DataSet_01_208
TWIST2 LIN28A siRNA Embryo H9 2.32707 1.21851 0.00228 0.02013 DataSet_01_215
TWIST2 MYC shRNA Soft_tissue HT1080 0.4248 -1.23516 - - DataSet_01_237
TWIST2 AR shRNA Prostate CWR22Pc 0.47657 -1.06924 0.08632 0.24438 DataSet_01_278
TWIST2 STAT5 shRNA Prostate CWR22Pc 2.07042 1.04992 0.00486 0.03466 DataSet_01_279
TWIST2 MSX1 siRNA Tooth Dental Pulp Cells 0.60271 -0.73046 1.25374e-05 0.00029 DataSet_01_281
TWIST2 ZIC5 siRNA Skin A375 0.27608 -1.85686 - - DataSet_01_284
TWIST2 SNAI2 siRNA Mammary_gland MCFDCIS 0.43141 -1.21288 0.00501 0.39968 DataSet_01_292
TWIST2 TFAP4 siRNA Brain BE(2)-C 0.2553 -1.96974 0.42934 0.51625 DataSet_01_295
TWIST2 PTEN shRNA Mammary_gland SKBR3 1.56779 0.64874 0.25126 0.70296 DataSet_01_303
TWIST2 SOX9 siRNA Prostate VCaP 0.50694 -0.9801 0.03606 0.9316 DataSet_01_308
TWIST2 SOX9 siRNA Prostate VCaP 0.50694 -0.9801 0.03606 0.9316 DataSet_01_309
TWIST2 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.61318 -0.70562 0.06651 0.3363 DataSet_01_313
TWIST2 ARNT siRNA Upper_aerodigestive_tract HSC3 0.22063 -2.18028 - - DataSet_01_315
TWIST2 ELK3 shRNA Mammary_gland MDA-MB-231 2.7314 1.44964 2.66721e-06 5.82972e-05 DataSet_01_318
TWIST2 PAX3 shRNA Soft_tissue Rh30 1.56472 0.64591 - - DataSet_01_359
TWIST2 SOX17 siRNA Umbilical_vein HUVEC 2.94668 1.55909 - - DataSet_01_360
TWIST2 GTF2B siRNA Cervix HeLa 0.51487 -0.95771 - - DataSet_01_362
TWIST2 ZNF622 shRNA Liver HepG2 0.125 -3 0.20448 0.27453 DataSet_02_108
TWIST2 HNRNPUL1 shRNA Liver HepG2 2 1 1 1 DataSet_02_109
TWIST2 TARDBP shRNA Liver HepG2 0.61111 -0.71049 0.16626 0.25046 DataSet_02_116
TWIST2 PTBP1 shRNA Liver HepG2 0.5 -1 0.05658 0.08476 DataSet_02_120
TWIST2 PCBP2 shRNA Liver HepG2 4 2 0.00933 0.0746 DataSet_02_123
TWIST2 FUS shRNA Liver HepG2 3 1.58496 0.04138 0.15866 DataSet_02_124
TWIST2 HNRNPLL shRNA Liver HepG2 0.16667 -2.58496 0.04285 0.08619 DataSet_02_125
TWIST2 SRSF3 shRNA Liver HepG2 0.61111 -0.71049 0.16589 0.3135 DataSet_02_127
TWIST2 ZFX siRNA Prostate C4-2B 0.28571 -1.80735 0.04097 0.09028 DataSet_02_172
TWIST2 ASCL1 siRNA Lung DMS79 2.18033 1.12454 0.303861680464062 0.873806620905198 DataSet_03_016
TWIST2 BCL6 siRNA Lymph Pfeiffer DLBCL 0.58789 -0.766381 0.182494991039915 0.660020716108199 DataSet_03_026
TWIST2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 1.57551 0.655815 - - DataSet_03_096
TWIST2 GATA2 siRNA Lymph Lymphatic endothelial cells 2.71551 1.44122 6.63505037574128e-08 7.31148525507327e-06 DataSet_03_101
TWIST2 GATA4 siRNA Stomach AGS 1.73484 0.794804 0.411493913097755 0.90650250250537 DataSet_03_105
TWIST2 GATA6 siRNA Stomach AGS 1.73254 0.792889 0.344978330634838 0.794232993990428 DataSet_03_108
TWIST2 GATA6 siRNA Stomach KatoIII 1.63368 0.708124 0.0738154821315296 0.584204974016317 DataSet_03_109
TWIST2 HNF4a siRNA Liver HepG2 1.85165 0.88881 0.197448647416886 0.797914563222443 DataSet_03_126
TWIST2 HOXC4 siRNA Skin Fibroblast 0.655546 -0.609231 0.00032016180023249 0.056811480059716 DataSet_03_128
TWIST2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.461765 -1.11477 0.286812627185773 0.999948959532916 DataSet_03_134
TWIST2 MEF2D shRNA Liver HuH7 0.530299 -0.915122 - - DataSet_03_162
TWIST2 MYC siRNA Central_nervous_system DAOY M2.1 0.663652 -0.591501 5.4598185594408e-06 3.03887253745138e-05 DataSet_03_178
TWIST2 PHB shRNA Embryo Embryonic stem cells (ESCs) 1.50333 0.588165 0.000420152422058068 0.00310843891344977 DataSet_03_211
TWIST2 RELB siRNA Immortalized_keratinocyte HaCaT 1.52593 0.609685 0.00094844539687917 0.00795774296733643 DataSet_03_227
TWIST2 SP1 siRNA Cervix HeLa 0.563313 -0.827992 5.97139984313057e-06 0.000350201452860779 DataSet_03_249
TWIST2 SP1 siRNA Mammary_gland MDA-MB-231 0.554 -0.852041 0.136216578145617 0.413972819854456 DataSet_03_250
TWIST2 STAT3 CRISPR Embryo hESC 0.582234 -0.780329 0.201921462589211 0.272021271808626 DataSet_03_258
TWIST2 TWIST2 siRNA Skin Fibroblast 0.176609 -2.50137 2.35894801902799e-10 8.16243193544066e-06 DataSet_03_284
TWIST2 ERN1 CRISPR Liver HepG2 0.5 -1 0.0461291644995975 0.183400206124112 DataSet_04_029
TWIST2 FUBP1 shRNA Liver HepG2 0.357143 -1.48543 0.0213574621088086 0.405437269786979 DataSet_04_030
TWIST2 SMAD2 CRISPR Liver HepG2 1.75 0.807355 0.443630557079534 0.824081041189235 DataSet_04_034
TWIST2 ZNF574 CRISPR Liver HepG2 1.88235 0.912537 0.00984143218434894 0.0718015715202162 DataSet_04_041
TWIST2 DDX20 CRISPR Liver HepG2 0.357143 -1.48543 0.0224349741334478 0.0963649697152827 DataSet_04_043
TWIST2 APTX CRISPR Liver HepG2 3.5 1.80735 0.596311664812941 0.957099639632747 DataSet_04_069
TWIST2 CNOT7 CRISPR Liver HepG2 1.91667 0.938599 0.200092945213884 0.348198774578807 DataSet_04_045
TWIST2 DNMT3B CRISPR Liver HepG2 2.66667 1.41504 0.567554058991048 0.793185675583568 DataSet_04_044
TWIST2 RIOK2 CRISPR Liver HepG2 2.25 1.16992 0.721980995936743 1 DataSet_04_070
TWIST2 SEPT11 CRISPR Liver HepG2 2.25 1.16992 0.322008900427073 0.585013904677224 DataSet_04_068
TWIST2 ABT1 shRNA Liver HepG2 0.181818 -2.45943 0.215512582234085 0.334091663223168 DataSet_04_052
TWIST2 CCAR1 shRNA Liver HepG2 7.33333 2.87447 0.367726978241805 0.526515181828142 DataSet_04_054
TWIST2 DDX1 shRNA Liver HepG2 3.2 1.67807 0.387274275237764 0.624281003701326 DataSet_04_057
TWIST2 ELF3 CRISPR Bile_duct HBDEC2 20.8768 4.38383 2.687243e-08 3.265845e-05 DataSet_03_304
TWIST2 SNAI2 shRNA Pancreas KLM1 0.0716912 -3.80206 2.961535e-02 0.24298164 DataSet_03_307
TWIST2 AEBP1 siRNA Central_nervous_system U87MG 0.594343 -0.750632 2.122228e-02 0.9431511 DataSet_03_338
TWIST2 BRCA1 siRNA Mammary_gland MCF7 1.71631 0.779311 1.130668e-02 0.8302312 DataSet_03_308
TWIST2 TET1 CRISPR Mammary_gland Hs578T 1.57436 0.654761 5.277452e-02 1.505956e-01 DataSet_03_355
TWIST2 PTPN14 CRISPR Brain U5-NPC 0.337972 -1.56503 4.385163e-02 0.26909166 DataSet_03_357
TWIST2 TP53 CRISPR Brain U5-NPC 1.58317 0.662816 2.157071e-01 3.483826e-01 DataSet_03_358
TWIST2 EP300 shRNA Mammary_gland MCF10AT 1.51905 0.603167 2.158491e-02 0.111209552 DataSet_03_364
TWIST2 TPR shRNA Bone_marrow U2OS 0.624845 -0.67843 1.453004e-02 1.757071e-01 DataSet_03_370
TWIST2 EZH2 CRISPR Ovary SKOV3 1.62811 0.703199 8.542934e-03 0.0693316565 DataSet_03_378
TWIST2 YY1 shRNA Brain GSC1517 0.505263 -0.984893 - - DataSet_03_384
TWIST2 YY1 shRNA Brain GSC3028 0.25 -2 - - DataSet_03_386
TWIST2 NFKBIA shRNA Bone_marrow U2OS 0.247918 -2.01206 5.039338e-01 0.87005461 DataSet_03_389
TWIST2 ILF2 siRNA Stomach SGC-7901 1.58148 0.661277 0.1258294729 0.29557328 DataSet_03_393
TWIST2 RELA CRISPR Brain T30 2.14191 1.0989 0.3094619578 0.8400824 DataSet_03_399
TWIST2 SUMO1 CRISPR Bone_marrow U2OS 0.273973 -1.8679 6.623454e-07 1.342837e-04 DataSet_03_401
TWIST2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.665114 -0.588327 4.360036e-02 0.150452233 DataSet_03_418
TWIST2 MAEL CRISPR Liver Alexander cells 0.114754 -3.12338 - - DataSet_03_423
TWIST2 FOXP3 CRISPR Peripheral_blood Naive Treg 0.110092 -3.18322 3.636689e-01 0.687233501 DataSet_03_427
TWIST2 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 6.4 2.67807 0.0604357707 1 DataSet_03_430
TWIST2 USP7 shRNA Skin xenograft cells 0.486486 -1.03953 0.28639599 0.4362749 DataSet_03_431
TWIST2 SUFU shRNA Mammary_gland HCC1954 cells 1.93827 0.954771 0.1235207081 0.6455297 DataSet_03_437
TWIST2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.28571 1.19265 1.490856e-01 0.90558273 DataSet_03_439
TWIST2 ZFP36L1 CRISPR Lung NCI-H1876 0.165574 -2.59445 8.446260e-02 0.960401433 DataSet_03_454
TWIST2 SMARCA2 shRNA Lung HCC2302 0.460245 -1.11953 1.030455e-12 1.700122e-11 DataSet_03_455
TWIST2 PARP1 knockout Embryo_kidney HEK293a 1.55564 0.637507 2.697737e-03 1.069341e-02 DataSet_03_464
TWIST2 STAT3 shRNA Liver HepG2 1.52059 0.604627 7.072796e-02 0.3967514505 DataSet_03_465
TWIST2 SMARCA1 Cas13 Embryo_kidney HEK293T 0.48 -1.05889 - - DataSet_03_466
TWIST2 EZH2 siRNA Prostate LNCaP 0.266667 -1.90689 4.137405e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate BCL11A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of TWIST2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines