Gene Overview
| Target Gene: | Alox5 |
| NCBI Official Symbol: | Alox5 |
| Entrez ID: | 11689 |
| Ensembl ID: | ENSMUSG00000025701 |
| Gene Full Name: | arachidonate 5-lipoxygenase |
| Strand: | - |
| Gene Locus: | 6 E3|6 53.79 cM |
| External Links: |
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Alox5 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Alox5
T(co)Fs
that Repress Alox5
The Intensity of the Gene Regulated by T(co)Fs:
Alox5-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Alox5 | Elf5 | knockout | Mammary_gland | Mammary gland | 1.66481 | 0.735362 | 0.110620846131267 | 0.394156840681774 | DataSet_11_035 |
| Alox5 | Foxa2 | knockout | Lung | Whole lung | 2.52765 | 1.3378 | 0.000219067823723616 | 0.046842120946923 | DataSet_11_041 |
| Alox5 | Gata2 | knockout | Kidney | renal collecting duct cells | 0.54375 | -0.878985 | - | - | DataSet_11_047 |
| Alox5 | Gata4 | knockout | Intestine | Jejunum | 1.75092 | 0.808115 | 0.142047077456053 | 0.64310390384436 | DataSet_11_049 |
| Alox5 | Gfi1 | knockout | Macrophage_cells | RAW264.7 | 0.439178 | -1.18712 | 5.02066004332634e-05 | 0.0006727342894744 | DataSet_11_052 |
| Alox5 | Hsf4 | knockout | Eye | Lens | 0.462019 | -1.11398 | 0.383119077856159 | 0.987999303842427 | DataSet_11_058 |
| Alox5 | Mafg | knockout | Embryo | Whole embryo | 0.576867 | -0.793689 | 0.302605378534612 | 1 | DataSet_11_073 |
| Alox5 | Mef2a | shRNA | Muscle | C2C12 | 0.425243 | -1.23364 | 2.07444286524704e-08 | 4.71071920691767e-06 | DataSet_11_077 |
| Alox5 | Myb | shRNA | Hematopoietic | AML cells | 3.03847 | 1.60334 | 8.65404439218738e-05 | 0.00381901137741188 | DataSet_11_084 |
| Alox5 | Neurod1 | knockout | Eye | Retina | 2.61824 | 1.3886 | 0.0129126899799324 | 0.0704813571507205 | DataSet_11_088 |
| Alox5 | Neurod1 | knockout | Eye | Pineal gland | 2.98323 | 1.57688 | 0.0124202027569335 | 0.9983937273602 | DataSet_11_089 |
| Alox5 | Nfil3 | knockout | Bone_marrow | Prepro NK cells | 0.570779 | -0.808995 | 0.267925942687355 | 0.596687909326533 | DataSet_11_090 |
| Alox5 | Nrf1 | knockdown | Liver | Liver | 3.62429 | 1.8577 | 0.0101385586771042 | 0.0467414671158995 | DataSet_11_096 |
| Alox5 | Pitx2 | knockout | Eye | Cornea | 0.375219 | -1.41419 | 0.275495638835816 | 0.673084036520709 | DataSet_11_103 |
| Alox5 | Plagl2 | knockout | Intestine | Small intestine | 0.60625 | -0.722015 | 0.0811153159566098 | 0.336218797542222 | DataSet_11_104 |
| Alox5 | Pparg | siRNA | Adipose_tissue | Preadipocytes | 1.688 | 0.755312 | 0.551670055483106 | 0.999962577291099 | DataSet_11_105 |
| Alox5 | Sall4 | shRNA | Embryo | ES cells | 0.504808 | -0.986194 | 0.0292365575859342 | 0.790999085949857 | DataSet_11_123 |
| Alox5 | Smad1 | knockout | Lung | Lung left lobe | 1.64764 | 0.720397 | 0.0837965715000552 | 0.542998753027287 | DataSet_11_126 |
| Alox5 | Sox17 | siRNA | Embryo | NG4 | 1.53875 | 0.621756 | 0.108672272873288 | 0.445536985899361 | DataSet_11_139 |
| Alox5 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 5.15662 | 2.36643 | 0.00482059204294023 | 0.0270567778699132 | DataSet_11_153 |
| Alox5 | Tbx1 | knockout | Ear | Otic vesicles | 1.70759 | 0.77196 | 0.342754321364689 | 0.996209135879357 | DataSet_11_154 |
| Alox5 | Tbx1 | knockout | Ear | Otic vesicles | 0.494441 | -1.01613 | 0.127970206964195 | 0.769373868910466 | DataSet_11_155 |
| Alox5 | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 1.51865 | 0.602793 | 8.054934e-01 | 0.9999923 | DataSet_11_187 |
| Alox5 | Cpeb1 | siRNA | Neuron | Neuro-2a | 0.269468 | -1.89181 | - | - | DataSet_11_189 |
| Alox5 | Mapk9 | knockout | Knee | Mouse total knee | 0.350754 | -1.51147 | 1.666422e-02 | 0.159683414 | DataSet_11_237 |
| Alox5 | Kdm5b | knockout | Heart | left ventricles | 1.51878 | 0.60291 | 0.5112495384 | 0.9999827 | DataSet_11_210 |
| Alox5 | Ncoa3 | shRNA | Embryo | ES cells | 1.7769 | 0.829363 | 4.844962e-11 | 5.478357e-09 | DataSet_11_194 |
| Alox5 | Ncoa3 | shRNA | Embryo | ES cells | 1.7769 | 0.829363 | 4.844962e-11 | 5.478357e-09 | DataSet_11_195 |
| Alox5 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 2.84043 | 1.50611 | - | - | DataSet_11_196 |
| Alox5 | Dnmt3b | knockout | Heart | Cardiac ventricle | 2.40957 | 1.26878 | 3.632819e-11 | 2.803537e-07 | DataSet_11_205 |
| Alox5 | Smarca4 | shRNA | Embryo | ES cells | 2.17558 | 1.1214 | - | - | DataSet_11_224 |
| Alox5 | Smarca4 | shRNA | Embryo | ES cells | 2.17558 | 1.1214 | - | - | DataSet_11_225 |
| Alox5 | Dux | siRNA | Embryo | ES cells | 1.66029 | 0.731433 | 1.870415e-01 | 0.8774371149 | DataSet_11_239 |
| Alox5 | Dnmt3a | siRNA | Embryo | iPSC | 0.467349 | -1.09743 | - | - | DataSet_11_241 |
| Alox5 | Dnmt3b | siRNA | Embryo | iPSC | 0.568148 | -0.815661 | - | - | DataSet_11_242 |
| Alox5 | Twist1 | knockout | Bone_marrow | stromal cells | 8.05347 | 3.00961 | - | - | DataSet_11_244 |
| Alox5 | Tet1 | shRNA | Muscle | MLL-ENL-ERtm | 0.429493 | -1.21929 | 1.630643e-02 | 3.720342e-02 | DataSet_11_249 |
| Alox5 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 0.340425 | -1.55459 | 7.220810e-02 | 1.883926e-01 | DataSet_11_250 |
| Alox5 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 4.79789 | 2.2624 | 2.560121e-03 | 0.031451440 | DataSet_11_252 |
| Alox5 | Crebbp | shRNA | Lung | preSC | 5 | 2.32193 | 1.534819e-02 | 0.33349609 | DataSet_11_255 |
| Alox5 | Brca1 | siRNA | Embryo | Embryonic fibroblasts | 1.73076 | 0.791408 | 0.0005124530 | 0.3808902 | DataSet_11_256 |
| Alox5 | Eed | knockout | Brain | Forebrain | 2.2242 | 1.15329 | 1.694656e-03 | 1.007471e-01 | DataSet_11_258 |
| Alox5 | Eed | knockout | Brain | hindbrain | 2.01314 | 1.00945 | 4.431765e-03 | 2.716271e-01 | DataSet_11_259 |
| Alox5 | Eed | knockout | Brain | midbrain | 1.58668 | 0.666008 | 3.720392e-02 | 6.393069e-01 | DataSet_11_260 |
| Alox5 | Fubp1 | shRNA | Bone_marrow | BM cells | 2.1878 | 1.12948 | 3.933471e-03 | 0.196481323 | DataSet_11_262 |
| Alox5 | Bcl3 | knockout | Bone | Osteoblast | 0.534483 | -0.903785 | 1.161383e-01 | 7.519931e-01 | DataSet_11_263 |
| Alox5 | Ctnnb1 | knockout | Embryo | MGE cells | 0.535243 | -0.901734 | 2.659968e-01 | 0.540920333 | DataSet_11_266 |
| Alox5 | Dux | knockout | Embryo | Embryo | 0.396362 | -1.33511 | 7.652555e-01 | 8.572444e-01 | DataSet_11_269 |
| Alox5 | Mef2d | CRISPR | Heart | Cardiac ventricle | 0.546112 | -0.872731 | 6.489866e-03 | 0.0871105856 | DataSet_11_270 |
| Alox5 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.0000637673 | -13.9368 | 3.479235e-01 | 0.81420760 | DataSet_11_272 |
| Alox5 | Dux | knockout | Embryo | Embryo | 0.396362 | -1.33511 | 7.652735e-01 | 8.572587e-01 | DataSet_11_273 |
| Alox5 | Myod1 | CRISPR | Skeletal_muscle | myoblast | 0.00644962 | -7.27657 | 1.906790e-09 | 4.998909e-07 | DataSet_11_275 |
| Alox5 | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 1.78065 | 0.8324 | 2.886192e-04 | 1.277014e-02 | DataSet_11_276 |
| Alox5 | Gsk3b | CRISPR | Neuron | mPFC D2 neurons | 0.180741 | -2.46801 | 6.263806e-01 | 0.91180839 | DataSet_11_277 |
| Alox5 | Ssrp1 | CRISPR | Embryo | ES cells | 3.06557 | 1.61616 | 3.832329e-01 | 0.7914316 | DataSet_11_278 |
| Alox5 | Usp7 | knockout | Embryo | ES cells | 3.84091 | 1.94145 | 1.439804e-03 | 0.2108785 | DataSet_11_279 |
| Alox5 | Pcgf6 | knockout | Liver | Liver | 2.42168 | 1.27601 | 2.644785e-01 | 0.9665401 | DataSet_11_281 |
| Alox5 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 1.71287 | 0.776417 | 6.613693e-02 | 0.6936949 | DataSet_11_283 |
| Alox5 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 0.155877 | -2.68152 | 2.493215e-01 | 0.5395938 | DataSet_11_284 |
| Alox5 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 2.11215 | 1.07871 | - | - | DataSet_11_285 |
| Alox5 | Pdx1 | CRISPR | Liver | Liver | 0.65 | -0.621488 | 5.727243e-01 | 0.705861738 | DataSet_11_286 |
| Alox5 | Fli1 | CRISPR | Lymph | CD8 T cells | 0.266667 | -1.90689 | 3.772120e-02 | 0.9999740103 | DataSet_11_288 |
| Alox5 | Irf8 | knockout | Brain | mice brain | 2.32476 | 1.21708 | 8.975356e-02 | 6.243205e-01 | DataSet_11_292 |
| Alox5 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 1.57439 | 0.654797 | 2.833286e-01 | 0.6162668943 | DataSet_11_294 |
| Alox5 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.48048 | -1.05745 | - | - | DataSet_11_305 |
| Alox5 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 0.168539 | -2.56884 | - | - | DataSet_11_306 |
| Alox5 | Suz12 | knockout | Lung | Alveolar macrophage | 1.5816 | 0.661389 | 1.844980e-01 | 2.623827e-01 | DataSet_11_312 |
| Alox5 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.498559 | -1.00417 | - | - | DataSet_11_313 |
| Alox5 | Actl6a | knockout | Nerve | sciatic nerve | 1.94759 | 0.961689 | 2.121031e-03 | 0.066727880 | DataSet_11_314 |
| Alox5 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 1.86628 | 0.900167 | 3.061168e-01 | 0.6567869602 | DataSet_11_317 |
| Alox5 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 1.90338 | 0.928561 | 1.223315e-01 | 0.7055669 | DataSet_11_318 |
| Alox5 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 1.69479 | 0.761103 | 1.008420e-01 | 4.224979e-01 | DataSet_11_319 |
| Alox5 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 2.15776 | 1.10953 | 1.410384e-01 | 3.411219e-01 | DataSet_11_320 |
| Alox5 | Bud31 | knockout | Testis | Spermatogonial stem cells | 0.153846 | -2.70044 | 5.742248e-01 | 0.8600602 | DataSet_11_321 |
| Alox5 | Gata2 | knockout | Brain | Pituitary gland | 3.57895 | 1.83953 | 0.150648948 | 0.9730581 | DataSet_11_322 |
| Alox5 | Setdb1 | shRNA | Neuron | NE-4C | 0.465573 | -1.10292 | - | - | DataSet_11_323 |
| Alox5 | Snai1 | knockdown | Heart | Heart | 0.637704 | -0.649041 | 2.225486e-01 | 0.44218638 | DataSet_11_326 |
| Alox5 | Dnmt1 | knockout | Brain | Cortex | 0.485441 | -1.04263 | 4.298009e-04 | 0.0356344029 | DataSet_11_329 |
| Alox5 | Kdm5b | siRNA | Embryo | ES cells | 0.653013 | -0.614817 | 0.4782990538 | 0.8933528 | DataSet_11_331 |
| Alox5 | Atrx | knockout | Embryo | ES cells | 3.71429 | 1.89309 | - | - | DataSet_11_335 |
| Alox5 | Dnmt3a | siRNA | Heart | embryonic cardiomyocytes | 1.70833 | 0.77259 | 4.501764e-02 | 0.53900308 | DataSet_11_337 |
| Alox5 | Dnmt3b | siRNA | Heart | embryonic cardiomyocytes | 2.29167 | 1.1964 | 1.739623e-02 | 0.41449475 | DataSet_11_338 |
| Alox5 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 2.65217 | 1.40717 | 0.0875645154 | 0.1718670 | DataSet_11_341 |
| Alox5 | Hnrnpk | siRNA | Embryo | ES cells | 2.97189 | 1.57138 | 1.338240e-03 | 0.008161427 | DataSet_11_342 |
| Alox5 | Pcbp1 | shRNA | Thymus | Th1 | 4 | 2 | 8.445578e-02 | 0.27591378 | DataSet_11_343 |
Regulation Region
Expression Atlas of Alox5