Gene Overview
Target Gene: CHRNB2
NCBI Official Symbol: CHRNB2
Entrez ID: 1141
Ensembl ID: ENSG00000160716
Gene Full Name: cholinergic receptor nicotinic beta 2 subunit
Strand: +
Gene Locus: 1q21.3
External Links:

CHRNB2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CHRNB2   
T(co)Fs that Repress CHRNB2
The Intensity of the Gene Regulated by T(co)Fs:
CHRNB2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CHRNB2 ZIC2 siRNA Pancreas PANC1 2.64851 1.40518 - - DataSet_01_121
CHRNB2 REST siRNA Adrenal_gland H295R/TR 2.12839 1.08977 2.48249e-06 0.0018 DataSet_01_145
CHRNB2 JUN siRNA Peripheral_blood CD4+ T cells 2.03384 1.02421 0.09385 0.27934 DataSet_01_164
CHRNB2 CREB1 shRNA Parotid_gland H3118 MEC 1.80083 0.84866 0.16286 0.51699 DataSet_01_194
CHRNB2 CREB1 shRNA Parotid_gland HSY 1.74088 0.79981 0.3346 0.96696 DataSet_01_195
CHRNB2 TP63 siRNA Head_and_neck SCC-1 1.55211 0.63423 - - DataSet_01_199
CHRNB2 TP63 siRNA Immortalized_keratinocyte HaCaT 0.63976 -0.6444 - - DataSet_01_200
CHRNB2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.64359 0.71685 - - DataSet_01_210
CHRNB2 REST siRNA Prostate LNCaP 31.5495 4.97954 0.0026 0.11752 DataSet_01_211
CHRNB2 LIN28A siRNA Embryo H9 0.43346 -1.20605 0.00175 0.01728 DataSet_01_215
CHRNB2 ESRRA shRNA Embryo_kidney 293T 2.25176 1.17105 0.06031 0.6669 DataSet_01_280
CHRNB2 POSTN shRNA Brain GSC272 2.48598 1.31382 0.09856 0.54681 DataSet_01_293
CHRNB2 TFAP4 siRNA Brain BE(2)-C 0.20589 -2.28006 0.36609 0.51625 DataSet_01_295
CHRNB2 PTEN shRNA Skin A431 2.78161 1.47592 0.03164 0.14771 DataSet_01_301
CHRNB2 NR2E1 shRNA Neuroepithelium PBT003 1.73968 0.79882 0.0076 0.42474 DataSet_01_306
CHRNB2 REST siRNA Skin NHEK 14.1418 3.82189 1.83973e-07 0.00021 DataSet_01_337
CHRNB2 REST siRNA Skin NHEK 15.6429 3.96743 1.53262e-05 0.02827 DataSet_01_338
CHRNB2 GATA3 siRNA Oral_cavity OEC-M1 0.49969 -1.0009 0.15814 0.99787 DataSet_01_347
CHRNB2 HIF1A siRNA Oral_cavity OEC-M1 1.53537 0.61859 0.12244 0.85151 DataSet_01_348
CHRNB2 RBM17 shRNA Liver HepG2 8.5 3.08746 0.01707 0.26816 DataSet_02_100
CHRNB2 U2AF2 shRNA Liver HepG2 4.66667 2.22239 0.01773 0.08743 DataSet_02_105
CHRNB2 TAF15 shRNA Liver HepG2 3.33333 1.73697 0.01781 0.04276 DataSet_02_106
CHRNB2 ZNF622 shRNA Liver HepG2 0.42857 -1.22239 0.18402 0.2523 DataSet_02_108
CHRNB2 GTF2F1 shRNA Liver HepG2 3.33333 1.73697 0.02418 0.26152 DataSet_02_110
CHRNB2 RBM39 shRNA Liver HepG2 3 1.58496 0.11086 0.3443 DataSet_02_111
CHRNB2 BCLAF1 shRNA Liver HepG2 2.69231 1.42884 0.00154 0.02576 DataSet_02_112
CHRNB2 U2AF2 shRNA Liver HepG2 5 2.32193 0.00684 0.06309 DataSet_02_113
CHRNB2 XRCC5 shRNA Liver HepG2 3 1.58496 0.05298 0.21435 DataSet_02_114
CHRNB2 PCBP1 shRNA Liver HepG2 2 1 0.17015 0.23854 DataSet_02_115
CHRNB2 TARDBP shRNA Liver HepG2 0.63636 -0.65208 0.7553 0.81578 DataSet_02_116
CHRNB2 PTBP1 shRNA Liver HepG2 3.33333 1.73697 0.02622 0.04623 DataSet_02_120
CHRNB2 EWSR1 shRNA Liver HepG2 6.8 2.76553 0.00203 0.04273 DataSet_02_122
CHRNB2 PCBP2 shRNA Liver HepG2 3 1.58496 0.0602 0.17912 DataSet_02_123
CHRNB2 FUS shRNA Liver HepG2 2.66667 1.41504 0.05276 0.17951 DataSet_02_124
CHRNB2 HNRNPLL shRNA Liver HepG2 0.18182 -2.45943 0.07983 0.1356 DataSet_02_125
CHRNB2 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.04107 0.16279 DataSet_02_142
CHRNB2 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.07907 0.27296 DataSet_02_164
CHRNB2 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.04582 1 DataSet_02_173
CHRNB2 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.65199 1 DataSet_02_174
CHRNB2 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.31579 -1.66297 0.09018 1 DataSet_02_179
CHRNB2 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 1.81818 0.8625 0.08909 1 DataSet_02_182
CHRNB2 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.27778 -1.848 0.00613 1 DataSet_02_184
CHRNB2 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.23366 1 DataSet_02_185
CHRNB2 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.30769 -1.70044 0.13562 1 DataSet_02_186
CHRNB2 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.45455 -1.1375 0.73219 1 DataSet_02_192
CHRNB2 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.42857 -1.22239 0.63732 1 DataSet_02_198
CHRNB2 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.36364 -1.45943 0.37245 1 DataSet_02_200
CHRNB2 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 0.58333 -0.77761 0.64062 1 DataSet_02_203
CHRNB2 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.25 1.16993 0.10487 1 DataSet_02_204
CHRNB2 ZFX siRNA Mammary_gland MCF7 0.52941 -0.91754 0.0152 0.11015 DataSet_02_206
CHRNB2 AR siRNA Prostate abl cells 2.04199 1.02997 0.0597925484997678 0.999852161656754 DataSet_03_004
CHRNB2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 3.03209 1.60031 - - DataSet_03_096
CHRNB2 GFP siRNA Mammary_gland BT-20 cells 0.5 -1 0.00536057642273373 0.308921715841846 DataSet_03_111
CHRNB2 MTA2 siRNA Stomach SGC-7901 2.20484 1.14067 - - DataSet_03_169
CHRNB2 MYB siRNA Cord_Blood CD34+ progenitor cells 1.83735 0.877628 - - DataSet_03_170
CHRNB2 MYC siRNA Colon HT29 1.55836 0.640024 - - DataSet_03_177
CHRNB2 REST siRNA Adrenal_gland H295R/TR 1.97005 0.978236 9.70254426397186e-07 0.000942238329834967 DataSet_03_228
CHRNB2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.288462 -1.79355 - - DataSet_03_246
CHRNB2 STAT3 CRISPR Embryo hESC 5.00731 2.32404 0.0430895636966328 0.116039906988927 DataSet_03_258
CHRNB2 ZNF746 siRNA Colon HCT116 3.58507 1.842 - - DataSet_03_293
CHRNB2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 120.765 6.91606 0.014142491689191 0.0615589577156627 DataSet_04_014
CHRNB2 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.647059 -0.628031 0.763446000509731 0.90317732448754 DataSet_04_022
CHRNB2 CIZ1 CRISPR Liver HepG2 0.642857 -0.63743 0.263516796425505 0.50151934407325 DataSet_04_026
CHRNB2 CTCF CRISPR Liver HepG2 0.5 -1 0.296715574711132 0.885833753999373 DataSet_04_027
CHRNB2 NFX1 CRISPR Liver HepG2 99.8 6.64097 4.02209915957786e-05 0.0107080024071796 DataSet_04_032
CHRNB2 SMAD2 CRISPR Liver HepG2 0.416667 -1.26303 0.41438081935269 0.808487542866792 DataSet_04_034
CHRNB2 DDX20 CRISPR Liver HepG2 0.5 -1 0.175520293867926 0.322073890864666 DataSet_04_043
CHRNB2 APTX CRISPR Liver HepG2 0.5 -1 0.568122346907123 0.953411498154345 DataSet_04_069
CHRNB2 RIOK2 CRISPR Liver HepG2 1.83333 0.874469 0.716525075470883 1 DataSet_04_070
CHRNB2 SEPT11 CRISPR Liver HepG2 2.2 1.1375 0.519071283602898 0.748503859210364 DataSet_04_068
CHRNB2 ABT1 shRNA Liver HepG2 5.4 2.43296 0.116540059876688 0.210756745959911 DataSet_04_052
CHRNB2 CALR shRNA Liver HepG2 3.33333 1.73697 0.564959577392806 0.697806142920139 DataSet_04_053
CHRNB2 CNOT7 shRNA Liver HepG2 4 2 0.347728198925401 0.456132445842878 DataSet_04_051
CHRNB2 DDX1 shRNA Liver HepG2 2.8 1.48543 0.499829928558952 0.71791092227867 DataSet_04_057
CHRNB2 NPM1 shRNA Liver HepG2 3.25 1.70044 0.631025649568035 0.915903895801973 DataSet_04_058
CHRNB2 PRPF6 shRNA Liver HepG2 25 4.64386 0.000399974801869534 0.0306260712278941 DataSet_04_056
CHRNB2 UBE2L3 shRNA Liver HepG2 0.4 -1.32193 0.787956860367733 0.882736491461383 DataSet_04_055
CHRNB2 YBX3 shRNA Liver HepG2 2.2 1.1375 0.606404579028595 0.765777294736312 DataSet_02_98
CHRNB2 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.705803558401018 0.947114275255233 DataSet_04_076
CHRNB2 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.672467524681787 0.846669730275523 DataSet_02_38
CHRNB2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.94444 0.959358 0.606966834905284 0.783873860983685 DataSet_02_32
CHRNB2 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.77778 1.91754 0.293579784819489 0.45158551728038 DataSet_02_47
CHRNB2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.590909 -0.758992 0.669269282973458 0.926608018389617 DataSet_02_49
CHRNB2 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.637698 -0.649056 1.222160e-01 0.6510154 DataSet_03_306
CHRNB2 SNAI2 shRNA Pancreas KLM1 0.589171 -0.763241 6.404489e-01 0.77438952 DataSet_03_307
CHRNB2 ACTR5 siRNA Muscle RD 5.54836 2.47206 - - DataSet_03_343
CHRNB2 INO80 siRNA Muscle RD 0.439531 -1.18596 - - DataSet_03_344
CHRNB2 EZH2 knockdown Colon HCT116 1.82017 0.86407 0.047306473 0.8488990 DataSet_03_334
CHRNB2 ZFX siRNA Mammary_gland MCF7 0.565155 -0.823281 5.291232e-02 1.765115e-01 DataSet_03_349
CHRNB2 EZH2 shRNA Mammary_gland LM2 0.654608 -0.611297 7.095903e-01 9.207961e-01 DataSet_03_350
CHRNB2 ETV5 knockdown Colon HT29 1.66667 0.736966 7.305996e-01 0.847387310 DataSet_03_353
CHRNB2 CREBBP CRISPR Brain U5-NPC 2.71429 1.44057 0.0575455826 0.7490853 DataSet_03_356
CHRNB2 TP53 CRISPR Brain U5-NPC 1.85714 0.893085 2.576907e-01 3.898702e-01 DataSet_03_358
CHRNB2 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.8982 0.924635 6.651092e-02 1.169080e-01 DataSet_03_362
CHRNB2 EP300 shRNA Mammary_gland MCF10AT 0.5 -1 7.302519e-01 0.831628217 DataSet_03_364
CHRNB2 ZFP36L1 siRNA Urinary_bladder J82 2.5 1.32193 - - DataSet_03_371
CHRNB2 E2F1 siRNA Nasopharynx HK1 0.6 -0.736966 8.526120e-01 1.000000e+00 DataSet_03_373
CHRNB2 ZNF213 siRNA Mammary_gland MCF7 0.51318 -0.962463 6.972474e-01 8.658877e-01 DataSet_03_376
CHRNB2 EZH2 CRISPR Ovary SKOV3 0.607143 -0.719892 2.638300e-01 0.4966825035 DataSet_03_378
CHRNB2 DDX5 shRNA Stomach HGC-27 0.25 -2 - - DataSet_03_379
CHRNB2 DNMT1 siRNA Skin Human melanoma cells 0.254532 -1.97408 2.669403e-05 2.061993e-04 DataSet_03_382
CHRNB2 YY1 shRNA Brain GSC1517 0.627119 -0.67319 - - DataSet_03_384
CHRNB2 TRIM8 siRNA Mammary_gland MCF7 0.37931 -1.39855 2.309571e-01 0.4455901903 DataSet_03_388
CHRNB2 NFKBIA shRNA Bone_marrow U2OS 0.0324112 -4.94736 4.549807e-01 0.87005461 DataSet_03_389
CHRNB2 KDM5A CRISPR Lung GLC16 0.634632 -0.656009 8.414148e-03 0.039044377 DataSet_03_392
CHRNB2 BMI1 shRNA Bile_duct QBC-939 0.260821 -1.93887 5.335463e-01 0.7161894365 DataSet_03_395
CHRNB2 JAZF1 siRNA Cervix HeLa Kyoto 2.23397 1.15961 4.643346e-01 0.862119084 DataSet_03_396
CHRNB2 IKZF2 CRISPR Lymph CAR T Cell 0.572107 -0.805643 8.401618e-01 0.979569948 DataSet_03_397
CHRNB2 TLE4 CRISPR Lymph CAR T Cell 0.306048 -1.70817 7.689309e-01 0.92784938 DataSet_03_398
CHRNB2 RELA CRISPR Brain T30 1.56156 0.64299 0.8731750496 0.9824373 DataSet_03_399
CHRNB2 CDK7 shRNA Bone_marrow D458 7.52632 2.91194 1.173016e-02 0.17808346 DataSet_03_404
CHRNB2 TFAP2A knockout Embryo H9 0.482972 -1.04999 7.356650e-03 0.05781474 DataSet_03_405
CHRNB2 CHD1 shRNA Prostate LNCaP 0.646258 -0.629817 2.363619e-02 3.429248e-01 DataSet_03_407
CHRNB2 STRAP knockout Nerve SK-N-AS 3.54971 1.8277 - - DataSet_03_409
CHRNB2 SIRT1 siRNA Pancreas PANC1 1.54167 0.624491 2.988971e-01 0.469463052 DataSet_03_410
CHRNB2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.625 -0.678072 6.387665e-01 0.753082926 DataSet_03_418
CHRNB2 FOXK2 shRNA Ovary OVCAR-5 2.16667 1.11548 1.090956e-01 0.29357087 DataSet_03_419
CHRNB2 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.388889 -1.36257 - - DataSet_03_422
CHRNB2 MAEL CRISPR Liver Alexander cells 3.07692 1.62149 - - DataSet_03_423
CHRNB2 IKZF2 shRNA Lymph Hut78 2.16439 1.11396 5.091491e-01 0.82276681 DataSet_03_429
CHRNB2 USP7 shRNA Skin xenograft cells 0.447412 -1.16032 0.25971084 0.4348960 DataSet_03_431
CHRNB2 EP300 knockout Pancreas HPAF-II orthotopic cells 0.102273 -3.28951 4.112073e-01 6.063364e-01 DataSet_03_436
CHRNB2 SUFU shRNA Mammary_gland HCC1954 cells 8 3 0.1672622350 0.6455297 DataSet_03_437
CHRNB2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.66667 0.736966 1.731503e-01 0.90558273 DataSet_03_439
CHRNB2 SETDB1 shRNA Colon HCT116 0.12432 -3.00786 - - DataSet_03_440
CHRNB2 CBX2 siRNA Mammary_gland MDA-MB-231 0.269829 -1.88988 5.063290e-01 7.165412e-01 DataSet_03_450
CHRNB2 CBX2 siRNA Mammary_gland MCF7 0.204007 -2.29331 2.403955e-01 0.3859379022 DataSet_03_451
CHRNB2 OGT siRNA Embryo BeWo cells 1.57143 0.652077 2.601140e-01 0.66237450 DataSet_03_453
CHRNB2 ZFP36L1 CRISPR Lung NCI-H1876 0.202733 -2.30234 3.074195e-01 0.992381486 DataSet_03_454
CHRNB2 ARID1A shRNA Bile_duct MMNK1 2.34554 1.22992 1.399545e-02 0.118827207 DataSet_03_458
CHRNB2 SOX9 knockout Liver HuH7 0.285714 -1.80735 2.845823e-01 4.338812e-01 DataSet_03_463
CHRNB2 WHSC1 siRNA Prostate PC3 2 1 7.323798e-01 0.84731784 DataSet_03_471
CHRNB2 EZH2 siRNA Prostate LNCaP 0.387249 -1.36867 - - DataSet_03_472
CHRNB2 CREBBP CRISPR Lymph U2932 6.33333 2.66297 4.475308e-02 1.0000000 DataSet_03_474
CHRNB2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.4355501 0.822935 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate REST by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CHRNB2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines