Gene Overview
| Target Gene: | Cdkn2a |
| NCBI Official Symbol: | Cdkn2a |
| Entrez ID: | 12578 |
| Ensembl ID: | ENSMUSG00000044303 |
| Gene Full Name: | cyclin dependent kinase inhibitor 2A |
| Strand: | - |
| Gene Locus: | 4 C4|4 42.15 cM |
| External Links: |
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Cdkn2a Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Cdkn2a
T(co)Fs
that Repress Cdkn2a
The Intensity of the Gene Regulated by T(co)Fs:
Cdkn2a-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Cdkn2a | Bcl6 | knockout | Bone_marrow | Myeloid cells | 0.338729 | -1.5618 | 7.625871782402e-07 | 8.02884297658882e-05 | DataSet_11_015 |
| Cdkn2a | Bhlha9 | knockout | Limb | Whole limb bud | 0.166919 | -2.58278 | - | - | DataSet_11_016 |
| Cdkn2a | Cebpb | shRNA | Mammary_gland | 4T1 mammary tumor cells | 0.209949 | -2.25189 | 0.133644112547947 | 0.999984070881864 | DataSet_11_022 |
| Cdkn2a | Cebpe | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.344979 | -1.53542 | - | - | DataSet_11_023 |
| Cdkn2a | Dmrt1 | knockout | Testis | Juvenile testes | 0.556333 | -0.845978 | 0.0103929472729354 | 0.365330030177305 | DataSet_11_025 |
| Cdkn2a | Dmrt1 | knockout | Ovary | Ovary | 1.73743 | 0.796956 | 8.20457375572961e-05 | 0.00905165235465893 | DataSet_11_030 |
| Cdkn2a | Dmrt1 | knockout | Ovary | Ovary | 1.73743 | 0.796956 | 8.20457375572961e-05 | 0.00905165235465893 | DataSet_11_031 |
| Cdkn2a | E2f4 | knockout | Brain | Forebrain | 0.6531 | -0.614623 | - | - | DataSet_11_033 |
| Cdkn2a | Elf5 | knockout | Mammary_gland | Mammary gland | 0.237237 | -2.0756 | 0.00816025463124686 | 0.202678332983165 | DataSet_11_035 |
| Cdkn2a | Foxa2 | knockout | Lung | Whole lung | 1.73873 | 0.79803 | 0.0281959349247005 | 0.323816105356154 | DataSet_11_041 |
| Cdkn2a | Foxp1 | knockout | Eye | Lens | 0.518345 | -0.948015 | - | - | DataSet_11_044 |
| Cdkn2a | Hsf4 | knockout | Eye | Lens | 2.35103 | 1.23329 | 0.454970918535297 | 0.987999303842427 | DataSet_11_058 |
| Cdkn2a | Junb | shRNA | Tibialis_anterior_muscle | Tibialis anterior muscle | 2.52528 | 1.33644 | 0.0957475576274382 | 0.322223511368363 | DataSet_11_065 |
| Cdkn2a | Lhx8 | knockout | Gonads | Oocytes | 0.640984 | -0.64164 | 0.00481703364602044 | 0.976218828789972 | DataSet_11_069 |
| Cdkn2a | Lhx8 | knockout | Ovary | Ovary | 0.299113 | -1.74124 | 0.000155461391520232 | 0.0102305911348938 | DataSet_11_070 |
| Cdkn2a | Mbd2 | knockout | Lymph | GFP+ BM leukemia cells | 1.9319 | 0.950021 | 0.00222556863816051 | 0.0196772259998141 | DataSet_11_076 |
| Cdkn2a | Meis1 | knockout | Hematopoietic | KSL hematopoietic cells | 0.636506 | -0.651753 | 0.339552595994195 | 0.995635220774426 | DataSet_11_081 |
| Cdkn2a | Myb | shRNA | Hematopoietic | AML cells | 2.10636 | 1.07475 | 0.00508426385147702 | 0.0378645301771939 | DataSet_11_084 |
| Cdkn2a | Myb | shRNA | Lung | Tracheal epithelial cell | 2.08256 | 1.05835 | 0.000220691044951843 | 0.0160780543071575 | DataSet_11_085 |
| Cdkn2a | Neurod1 | knockout | Eye | Pineal gland | 1.6592 | 0.730486 | 0.152720567240242 | 0.9983937273602 | DataSet_11_089 |
| Cdkn2a | Nhlh2 | knockout | Eye | Retina | 0.609195 | -0.715023 | 0.416668768046746 | 0.57313393709269 | DataSet_11_092 |
| Cdkn2a | Otx2 | knockout | Eye | Retina | 1.75829 | 0.814176 | 0.147543432611302 | 0.999923528647439 | DataSet_11_097 |
| Cdkn2a | Pitx2 | knockout | Eye | Cornea | 2.27749 | 1.18745 | 0.396488215933851 | 0.704301896114389 | DataSet_11_103 |
| Cdkn2a | Pparg | siRNA | Adipose_tissue | Preadipocytes | 1.51366 | 0.598037 | 0.882174881269188 | 0.999962577291099 | DataSet_11_105 |
| Cdkn2a | Prdm14 | knockout | Embryo | ES cells | 0.649429 | -0.622756 | 8.3213635034729e-06 | 0.000198346843710305 | DataSet_11_107 |
| Cdkn2a | Prdm2 | shRNA | Muscle | C2C12 | 0.558332 | -0.840805 | 0.0209621012732842 | 0.692227349198187 | DataSet_11_108 |
| Cdkn2a | Prox1 | knockout | Liver | Liver | 1.80811 | 0.854483 | - | - | DataSet_11_109 |
| Cdkn2a | Rest | knockout | Brain | Brain | 1.68116 | 0.749457 | 0.816377191764344 | 1 | DataSet_11_113 |
| Cdkn2a | Runx1 | knockout | Bone_marrow | KSL cells | 1.74988 | 0.807261 | 0.117106462635977 | 0.908882788108295 | DataSet_11_115 |
| Cdkn2a | Sall4 | shRNA | Embryo | ES cells | 2.23741 | 1.16183 | 0.139844915947518 | 0.999840995136314 | DataSet_11_123 |
| Cdkn2a | Smad4 | siRNA | Brain | bEnd3 | 0.107163 | -3.22213 | - | - | DataSet_11_127 |
| Cdkn2a | Smad4 | knockout | Aorta | Aortic arteries | 0.174433 | -2.51925 | 0.00137752588382166 | 0.0887174895769561 | DataSet_11_128 |
| Cdkn2a | Snai1 | knockout | Embryo | Embryoid body | 3.50002 | 1.80736 | - | - | DataSet_11_129 |
| Cdkn2a | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.320038 | -1.64369 | 0.0386183374133571 | 0.122963300013884 | DataSet_11_153 |
| Cdkn2a | Tbx1 | knockout | Ear | Otic vesicles | 1.86273 | 0.897416 | 0.24839539073913 | 0.996209135879357 | DataSet_11_154 |
| Cdkn2a | Tbx1 | knockout | Ear | Otic vesicles | 1.89118 | 0.919289 | 0.559298001400114 | 0.917172663428191 | DataSet_11_155 |
| Cdkn2a | Thap11 | knockout | Embryo | ES cells | 1.62363 | 0.699226 | 7.64035030535863e-05 | 0.00576329871827112 | DataSet_11_168 |
| Cdkn2a | Yy1 | knockout | White_adipose_tissue | Visceral white adipose tissue | 1.53487 | 0.618119 | 0.00253817729324592 | 0.0326233379318285 | DataSet_11_185 |
| Cdkn2a | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 0.650259 | -0.620913 | 2.064848e-01 | 0.9999923 | DataSet_11_187 |
| Cdkn2a | Pogz | knockdown | Liver | fetal liver | 0.053273 | -4.23045 | 1.427263e-02 | 0.3028267 | DataSet_11_188 |
| Cdkn2a | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.440866 | -1.18159 | 3.220658e-02 | 1.213434e-01 | DataSet_11_192 |
| Cdkn2a | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 1.61882 | 0.694942 | - | - | DataSet_11_196 |
| Cdkn2a | Ezh2 | knockout | Bone_marrow | CD45.2+LSK cells | 1.83653 | 0.876985 | - | - | DataSet_11_220 |
| Cdkn2a | Dnmt3a | siRNA | Peritoneum | peritoneal macrophages | 0.358503 | -1.47994 | - | - | DataSet_11_222 |
| Cdkn2a | Smarca4 | shRNA | Embryo | ES cells | 1.78373 | 0.8349 | - | - | DataSet_11_224 |
| Cdkn2a | Smarca4 | shRNA | Embryo | ES cells | 1.78373 | 0.8349 | - | - | DataSet_11_225 |
| Cdkn2a | Dnmt3a | siRNA | Embryo | iPSC | 2.71777 | 1.44242 | - | - | DataSet_11_241 |
| Cdkn2a | Kat6a | knockout | Embryo | Embryonic fibroblasts | 2.41429 | 1.2716 | 6.341608e-03 | 0.0760746842 | DataSet_11_245 |
| Cdkn2a | Ezh2 | knockout | Calvaria | calvaria | 3.37838 | 1.75633 | 1.041214e-03 | 0.26633444 | DataSet_11_247 |
| Cdkn2a | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 2.13342 | 1.09317 | 1.104845e-02 | 5.045460e-02 | DataSet_11_250 |
| Cdkn2a | Kdm2a | CRISPR | Embryo | ES cells | 0.370301 | -1.43323 | 0.0076481831 | 0.9447699 | DataSet_11_251 |
| Cdkn2a | Eed | knockout | Brain | Forebrain | 281.195 | 8.13543 | 4.283688e-11 | 1.143445e-06 | DataSet_11_258 |
| Cdkn2a | Eed | knockout | Brain | hindbrain | 376.649 | 8.55708 | 4.515641e-15 | 1.132252e-10 | DataSet_11_259 |
| Cdkn2a | Eed | knockout | Brain | midbrain | 381.278 | 8.5747 | 3.866244e-12 | 4.896599e-08 | DataSet_11_260 |
| Cdkn2a | Eed | knockout | Spinal_cord | spinal cord | 199.069 | 7.63712 | 4.339291e-11 | 5.569479e-07 | DataSet_11_261 |
| Cdkn2a | Fubp1 | shRNA | Bone_marrow | BM cells | 0.439836 | -1.18496 | 4.461380e-02 | 0.450079562 | DataSet_11_262 |
| Cdkn2a | Nsd2 | knockout | Bone_marrow | Bone marrow immature B cells | 3.00002 | 1.58497 | 2.159439e-03 | 0.05628985 | DataSet_11_267 |
| Cdkn2a | Dux | knockout | Embryo | Embryo | 1.98333 | 0.987927 | 2.851916e-01 | 4.690180e-01 | DataSet_11_269 |
| Cdkn2a | Mef2d | CRISPR | Heart | Cardiac ventricle | 0.478715 | -1.06276 | 3.426012e-01 | 0.5801022454 | DataSet_11_270 |
| Cdkn2a | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 2.79739 | 1.48408 | 4.912545e-01 | 0.84325664 | DataSet_11_272 |
| Cdkn2a | Dux | knockout | Embryo | Embryo | 1.98333 | 0.987927 | 2.851914e-01 | 4.690107e-01 | DataSet_11_273 |
| Cdkn2a | Ssrp1 | CRISPR | Embryo | ES cells | 2.15194 | 1.10564 | 2.758326e-03 | 0.4522622 | DataSet_11_278 |
| Cdkn2a | Usp7 | knockout | Embryo | ES cells | 1.83692 | 0.877291 | 5.383019e-02 | 0.4424360 | DataSet_11_279 |
| Cdkn2a | Pcgf6 | knockout | Brain | Brain | 1.54428 | 0.626934 | 6.496550e-01 | 0.989767855 | DataSet_11_280 |
| Cdkn2a | Pcgf6 | knockout | Liver | Liver | 0.300506 | -1.73453 | 2.927965e-01 | 0.9665401 | DataSet_11_281 |
| Cdkn2a | Pdx1 | CRISPR | Liver | Liver | 0.439394 | -1.18641 | 1.551431e-02 | 0.320198855 | DataSet_11_286 |
| Cdkn2a | Fli1 | CRISPR | Lymph | CD8 T cells | 0.372414 | -1.42502 | 1.356885e-01 | 0.9999740103 | DataSet_11_288 |
| Cdkn2a | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 1.54902 | 0.631355 | 7.225955e-01 | 0.8883859079 | DataSet_11_294 |
| Cdkn2a | Ssrp1 | CRISPR | Embryo | ES cells | 8.77778 | 3.13386 | 4.175723e-03 | 0.10683916 | DataSet_11_296 |
| Cdkn2a | Phf8 | knockout | prostate | Prostate | 2.59031 | 1.37313 | 0.0796306158 | 0.3114482 | DataSet_11_298 |
| Cdkn2a | Arid2 | knockout | Muscle | LSK | 1.625 | 0.70044 | 8.487235e-01 | 1.000000e+00 | DataSet_11_301 |
| Cdkn2a | Dnmt1 | knockout | Skin | Keratinocytes | 9.47986 | 3.24487 | 3.403113e-04 | 0.0166421767 | DataSet_11_303 |
| Cdkn2a | Satb2 | CRISPR | Colon | Colon organoid | 1.53566 | 0.618858 | 5.574042e-02 | 0.6518149 | DataSet_11_304 |
| Cdkn2a | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.42735 | -1.22651 | - | - | DataSet_11_305 |
| Cdkn2a | Esr1 | knockout | Liver | Liver | 2.14815 | 1.10309 | 1.250267e-01 | 1.0000000 | DataSet_11_307 |
| Cdkn2a | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 5.62535 | 2.49194 | 4.363711e-01 | 0.81315222 | DataSet_11_310 |
| Cdkn2a | Suz12 | knockout | Lung | Alveolar macrophage | 18.6601 | 4.22189 | 2.794436e-03 | 0.0768698741 | DataSet_11_311 |
| Cdkn2a | Suz12 | knockout | Lung | Alveolar macrophage | 18.4216 | 4.20333 | 1.915162e-04 | 6.639364e-03 | DataSet_11_312 |
| Cdkn2a | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.411706 | -1.28031 | - | - | DataSet_11_313 |
| Cdkn2a | Ahr | knockout | Liver | Liver | 0.347826 | -1.52356 | 1.997992e-02 | 0.3245111952 | DataSet_11_315 |
| Cdkn2a | Satb2 | knockout | Colon | Intestine epithelium | 2.83511 | 1.50341 | 5.377350e-01 | 0.7332566114 | DataSet_11_316 |
| Cdkn2a | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 1.89877 | 0.925067 | 2.637433e-01 | 0.7527440 | DataSet_11_318 |
| Cdkn2a | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.334029 | -1.58195 | 8.398991e-03 | 2.570001e-01 | DataSet_11_319 |
| Cdkn2a | Snai1 | knockdown | Heart | Heart | 1.62796 | 0.703062 | 2.992457e-01 | 0.51146851 | DataSet_11_326 |
| Cdkn2a | Ezh2 | knockout | Eye | Retina | 0.0138889 | -6.16993 | 2.353319e-10 | 1.569762e-07 | DataSet_11_333 |
| Cdkn2a | Ezh2 | knockout | Eye | Retina | 7.43039 | 2.89344 | 0.1242470335 | 1.0000000 | DataSet_11_334 |
| Cdkn2a | Atrx | knockout | Embryo | ES cells | 0.545455 | -0.874469 | - | - | DataSet_11_335 |
| Cdkn2a | Dnmt3a | siRNA | Heart | embryonic cardiomyocytes | 0.3097 | -1.69106 | 7.629227e-03 | 0.27452591 | DataSet_11_337 |
| Cdkn2a | Gtf2ird1 | knockout | Lip | Lip | 11 | 3.45943 | 4.864244e-04 | 3.260746e-02 | DataSet_11_339 |
| Cdkn2a | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.44765 | -1.15955 | 4.206728e-03 | 0.014139528 | DataSet_11_340 |
| Cdkn2a | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 0.5 | -1 | 0.6754379053 | 0.7227613 | DataSet_11_341 |
| Cdkn2a | Hnrnpk | siRNA | Embryo | ES cells | 0.453297 | -1.14147 | 7.786081e-03 | 0.022984277 | DataSet_11_342 |
Regulation Region
Expression Atlas of Cdkn2a