Gene Overview
Target Gene: FGA
NCBI Official Symbol: FGA
Entrez ID: 2243
Ensembl ID: ENSG00000171560
Gene Full Name: fibrinogen alpha chain
Strand: -
Gene Locus: 4q31.3
External Links:

FGA Significantly Regulated by These T(co)Fs

T(co)Fs that Activate FGA   
T(co)Fs that Repress FGA
The Intensity of the Gene Regulated by T(co)Fs:
FGA-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
FGA SPDEF shRNA Mammary_gland MCF7 0.36019 -1.47315 0.49801 0.99999 DataSet_01_107
FGA FOXM1 siRNA Central_nervous_system U87 2.47361 1.30662 - - DataSet_01_122
FGA NFYA shRNA Cervix HeLaS3 1.58727 0.66655 0.00286 0.0342 DataSet_01_131
FGA ELK1 siRNA Peripheral_blood CD4+ T cells 0.37197 -1.42676 0.04408 0.14379 DataSet_01_162
FGA GATA3 siRNA Peripheral_blood CD4+ T cells 0.59395 -0.75159 0.31184 0.65644 DataSet_01_163
FGA JUN siRNA Peripheral_blood CD4+ T cells 0.33094 -1.59535 0.02416 0.12222 DataSet_01_164
FGA MAF siRNA Peripheral_blood CD4+ T cells 0.34987 -1.51512 0.032 0.20891 DataSet_01_165
FGA NFATC3 siRNA Peripheral_blood CD4+ T cells 0.37311 -1.42233 0.04444 0.22067 DataSet_01_166
FGA NFKB1 siRNA Peripheral_blood CD4+ T cells 0.45106 -1.14861 0.1084 0.67337 DataSet_01_167
FGA HSF1 shRNA Liver KYN2 0.63897 -0.64618 - - DataSet_01_178
FGA GABPA shRNA Prostate C4-2B 961.13 9.90859 0.23724 0.43934 DataSet_01_190
FGA GABPA shRNA Prostate LNCaP 696.611 9.44421 0.46308 0.7048 DataSet_01_191
FGA GATA2 siRNA Prostate LNCaP 0.51355 -0.96141 0.05458 0.12681 DataSet_01_193
FGA CREB1 shRNA Parotid_gland H3118 MEC 7.08267 2.82429 0.2462 0.61202 DataSet_01_194
FGA TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.169 -2.56488 - - DataSet_01_196
FGA TP63 siRNA Head_and_neck SCC-1 0.28082 -1.83231 - - DataSet_01_198
FGA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.56705 -0.81844 - - DataSet_01_208
FGA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.23726 1.16174 - - DataSet_01_209
FGA HIF1A shRNA Liver HepG2 0.43141 -1.21287 4.08668e-07 0.00105 DataSet_01_220
FGA IRX1 shRNA Bone_marrow 143B 0.50479 -0.98624 0.76914 0.88558 DataSet_01_227
FGA ESRRA shRNA Embryo_kidney 293T 0.5346 -0.90346 0.07188 0.6838 DataSet_01_280
FGA POSTN shRNA Brain GSC272 4.03422 2.01229 0.03056 0.52147 DataSet_01_293
FGA TFAP4 siRNA Brain BE(2)-C 0.2155 -2.21423 0.36666 0.51625 DataSet_01_295
FGA SOX17 siRNA Umbilical_vein HUVEC 1.51113 0.59563 0.54152 0.99998 DataSet_01_300
FGA PTEN shRNA Lung HCC827 0.54507 -0.87548 0.00434 0.36396 DataSet_01_302
FGA PTEN shRNA Mammary_gland SKBR3 1.53146 0.6149 0.42797 0.78953 DataSet_01_303
FGA SOX9 siRNA Prostate VCaP 0.47535 -1.07293 0.02621 0.9316 DataSet_01_308
FGA SOX9 siRNA Prostate VCaP 0.47535 -1.07293 0.02621 0.9316 DataSet_01_309
FGA ARNT siRNA Upper_aerodigestive_tract HSC3 0.22045 -2.1815 - - DataSet_01_315
FGA HOXC6 siRNA Prostate LNCaP 0.38409 -1.3805 0.01847 0.99927 DataSet_01_333
FGA RBM17 shRNA Liver HepG2 0.65174 -0.61763 0.09337 0.35354 DataSet_02_100
FGA SAFB2 shRNA Liver HepG2 0.23372 -2.09717 3.54293e-05 0.02192 DataSet_02_102
FGA FIP1L1 shRNA Liver HepG2 0.40102 -1.31824 0.00036 0.01124 DataSet_02_103
FGA U2AF2 shRNA Liver HepG2 1.62829 0.70336 0.95228 0.97291 DataSet_02_105
FGA SSB shRNA Liver HepG2 5.28623 2.40224 1.8692e-05 0.00314 DataSet_02_107
FGA RBM39 shRNA Liver HepG2 1.65365 0.72565 0.05713 0.26568 DataSet_02_111
FGA BCLAF1 shRNA Liver HepG2 1.99282 0.99481 0.00102 0.02512 DataSet_02_112
FGA XRCC5 shRNA Liver HepG2 0.65907 -0.60149 0.00955 0.14276 DataSet_02_114
FGA PCBP1 shRNA Liver HepG2 2.25584 1.17367 0.00015 0.01339 DataSet_02_115
FGA TARDBP shRNA Liver HepG2 3.17939 1.66875 0.00222 0.01974 DataSet_02_116
FGA PCBP2 shRNA Liver HepG2 3.15984 1.65985 0.00026 0.04878 DataSet_02_123
FGA HNRNPLL shRNA Liver HepG2 5.3472 2.41878 0.00058 0.01179 DataSet_02_125
FGA SNRNP70 shRNA Liver HepG2 8.97872 3.16651 0.00024 0.03074 DataSet_02_126
FGA TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.04827 0.30605 DataSet_02_129
FGA PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.10504 0.18648 DataSet_02_131
FGA SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.06092 0.17132 DataSet_02_134
FGA PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_135
FGA HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.49409 0.67556 DataSet_02_136
FGA RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 1.6 0.67807 0.11388 0.38702 DataSet_02_138
FGA RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 35 5.12928 0.08525 0.14475 DataSet_02_143
FGA DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.05299 0.51061 DataSet_02_145
FGA CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.85078 0.96549 DataSet_02_146
FGA HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.05508 0.51515 DataSet_02_156
FGA SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_161
FGA RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.07684 0.17506 DataSet_02_168
FGA TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.49285 0.58964 DataSet_02_169
FGA ZFX siRNA Prostate C4-2B 2 1 0.57168 0.67631 DataSet_02_172
FGA LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.32554 1 DataSet_02_175
FGA CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.20805 1 DataSet_02_176
FGA ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.07303 1 DataSet_02_177
FGA STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.61317 1 DataSet_02_182
FGA MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.45565 1 DataSet_02_183
FGA CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.27088 1 DataSet_02_185
FGA MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.17849 1 DataSet_02_189
FGA RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.91032 1 DataSet_02_190
FGA LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.90847 1 DataSet_02_191
FGA BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.06975 1 DataSet_02_202
FGA RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 6.5 2.70044 0.11914 1 DataSet_02_204
FGA AR siRNA Prostate LNCaP 1.74468 0.802963 0.248150790372103 1 DataSet_03_005
FGA ARID2 CRISPR Liver JHH4 3.13532 1.64861 0.445008275726415 1 DataSet_03_015
FGA ATF4 siRNA Skin A375 0.537632 -0.895309 0.0727676772224018 0.775512819201899 DataSet_03_018
FGA FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 2.20883 1.14328 - - DataSet_03_096
FGA GATA4 siRNA Stomach AGS 1.74307 0.801629 0.0207375406036007 0.551491957237566 DataSet_03_105
FGA GFP siRNA Mammary_gland BT-20 cells 0.578947 -0.788496 0.0195795614175532 0.45245734192902 DataSet_03_111
FGA HIC1 CRISPR Prostate PC3 0.383396 -1.38309 - - DataSet_03_118
FGA HIF3A siRNA Liver Hep3B 0.574349 -0.8 0.429427287526072 1 DataSet_03_120
FGA HIF3A siRNA Liver Hep3B 0.574349 -0.8 0.429427287526072 1 DataSet_03_121
FGA KLF5 siRNA Stomach AGS 3.17431 1.66644 0.000587178598797434 0.0963284284618063 DataSet_03_149
FGA KLF5 siRNA Stomach YCC3 3.34582 1.74236 0.00232568703806079 0.0795620107570401 DataSet_03_151
FGA MEF2D shRNA Liver HuH7 0.396306 -1.33531 - - DataSet_03_162
FGA MTA2 siRNA Stomach SGC-7901 1.68592 0.753538 - - DataSet_03_169
FGA MYB siRNA Cord_Blood CD34+ progenitor cells 2.42098 1.27559 - - DataSet_03_170
FGA MYC siRNA Colon HT29 2.34334 1.22856 - - DataSet_03_177
FGA SOX2 CRISPR Seminoma-like TCam-2 4.94973 2.30735 0.0678592821455385 0.999580851453413 DataSet_03_244
FGA SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.60131 0.67925 - - DataSet_03_246
FGA STAT3 CRISPR Embryo hESC 0.616868 -0.696966 0.470713389818456 0.542281368538405 DataSet_03_258
FGA E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0769231 -3.70044 0.0219568780369776 0.463432466188928 DataSet_04_007
FGA EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.629133988598292 0.83201832518959 DataSet_04_008
FGA ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0615385 -4.02237 0.00494848158128519 0.476887905400229 DataSet_04_009
FGA RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.571429 -0.807355 0.214025956081722 0.617370237267513 DataSet_04_017
FGA SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.107692 -3.21501 0.0105914972048202 0.394951331771279 DataSet_04_020
FGA APTX CRISPR Liver HepG2 0.107692 -3.21501 0.0095825473709036 0.4173270038609 DataSet_04_025
FGA NFX1 CRISPR Liver HepG2 3.04353 1.60575 9.42875439986597e-05 0.0107080024071796 DataSet_04_032
FGA ACTN4 CRISPR Liver HepG2 2.44854 1.29192 0.000392257016846183 0.0303319882215145 DataSet_04_042
FGA ABT1 shRNA Liver HepG2 3.23879 1.69545 9.50602779341866e-06 0.00118215111124821 DataSet_04_052
FGA CALR shRNA Liver HepG2 1.77236 0.825668 0.000123753507866476 0.00388216921868329 DataSet_04_053
FGA CCAR1 shRNA Liver HepG2 1.79276 0.842185 0.000196830832012772 0.0103075326408406 DataSet_04_054
FGA CNOT7 shRNA Liver HepG2 0.441547 -1.17936 0.000138482112259564 0.00299857923637623 DataSet_04_051
FGA DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.826838274143469 0.979655190278957 DataSet_04_047
FGA SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.25 1.16992 0.649764098858277 0.901394884465332 DataSet_04_073
FGA SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.25 1.16992 0.613491172395055 0.761149035368813 DataSet_04_049
FGA HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.57143 0.652077 0.653759011556268 0.887694456197778 DataSet_02_75
FGA HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.3 1.72247 0.461657386977223 0.825072258005318 DataSet_02_45
FGA LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.8 0.847997 0.562194013294315 0.729639878796075 DataSet_02_35
FGA NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.45 1.29278 0.449203620172267 0.674543636549182 DataSet_02_32
FGA SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.3 -1.73697 0.556965144094977 0.705125392783506 DataSet_02_47
FGA SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.272727 -1.87447 0.671746373385432 0.927453544203268 DataSet_02_49
FGA TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.42879373099693 0.589883756631005 DataSet_02_33
FGA TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.9 1.53605 0.267611210909014 0.434640516570906 DataSet_02_53
FGA ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.254545 -1.974 0.0758725000604681 0.177074623096133 DataSet_04_060
FGA UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 6.5 2.70044 0.186616086840947 0.427166462414753 DataSet_04_062
FGA CNOT3 shRNA Lung A549 0.272509 -1.87562 4.616951e-02 0.8830540 DataSet_03_340
FGA SMARCA4 siRNA Colon HCT116 0.529472 -0.917373 6.468336e-03 0.1310570 DataSet_03_302
FGA HDAC5 siRNA Liver human hepatocytes 0.343024 -1.54362 5.843704e-10 4.988755e-06 DataSet_03_346
FGA PRMT1 shRNA Lung A549 2.16967 1.11748 - - DataSet_03_342
FGA PARP1 siRNA Prostate LNCaP 2.83538 1.50354 3.219086e-01 0.611256911 DataSet_03_354
FGA TET1 CRISPR Mammary_gland Hs578T 1.80784 0.854264 5.577607e-01 7.283734e-01 DataSet_03_355
FGA USP22 shRNA Liver PLC_PRF_5 cells 2.09065 1.06395 7.922375e-03 0.10918184 DataSet_03_368
FGA TPR shRNA Bone_marrow U2OS 0.100534 -3.31424 5.634555e-01 8.907222e-01 DataSet_03_370
FGA BHLHE40 shRNA Cervix HeLaS3 27.5 4.78136 2.534516e-01 0.84447131 DataSet_03_372
FGA E2F1 siRNA Nasopharynx HK1 1.66667 0.736966 3.571404e-01 9.722824e-01 DataSet_03_373
FGA EZH2 CRISPR Ovary SKOV3 0.230769 -2.11548 8.288713e-02 0.2465983405 DataSet_03_378
FGA ASXL1 CRISPR Embryo iPSC 1.8649 0.899096 0.3767340689 0.8395482 DataSet_03_394
FGA HMGA1 shRNA Bile_duct HUCCT1 1.5641 0.645335 1.130703e-01 0.372650390 DataSet_03_400
FGA CHD1 shRNA Prostate LNCaP 0.444444 -1.16992 7.507080e-03 1.976096e-01 DataSet_03_407
FGA MAP3K7 shRNA Prostate LNCaP 0.5 -1 4.545173e-02 1.945801e-01 DataSet_03_408
FGA USP22 shRNA Liver HuH7 1.89455 0.921856 - - DataSet_03_411
FGA E2F1 siRNA Prostate LNCaP 2 1 5.300378e-01 0.8184360010 DataSet_03_413
FGA FOXK2 shRNA Ovary OVCAR-5 0.00632911 -7.30378 1.959045e-03 0.08266460 DataSet_03_419
FGA EP300 knockout Pancreas HPAF-II orthotopic cells 0.3375 -1.56704 5.761221e-01 7.364118e-01 DataSet_03_436
FGA FOSL1 siRNA Prostate MSKPCa3 0.277778 -1.848 0.0327857660 0.3983035 DataSet_03_445
FGA SMARCA2 shRNA Lung HCC2302 244.837 7.93568 1.051610e-10 8.615592e-10 DataSet_03_455
FGA ARID1A shRNA Bile_duct MMNK1 0.262481 -1.92972 2.345960e-01 0.545953811 DataSet_03_458
FGA WHSC1 siRNA Prostate PC3 3 1.58496 2.582314e-01 0.50619294 DataSet_03_471
FGA EZH2 siRNA Prostate LNCaP 0.458333 -1.12553 4.653111e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of FGA
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines