Gene Overview
| Target Gene: | Gjb2 |
| NCBI Official Symbol: | Gjb2 |
| Entrez ID: | 14619 |
| Ensembl ID: | ENSMUSG00000046352 |
| Gene Full Name: | gap junction protein, beta 2 |
| Strand: | - |
| Gene Locus: | 14 C3|14 30.1 cM |
| External Links: |
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Gjb2 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Gjb2
T(co)Fs
that Repress Gjb2
The Intensity of the Gene Regulated by T(co)Fs:
Gjb2-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Gjb2 | Adnp | knockout | Embryo | Whole embryonic body | 2.1422 | 1.09909 | 0.00235607035319998 | 0.242443615071769 | DataSet_11_001 |
| Gjb2 | Atoh1 | knockout | Gastrointestinal_tissue | Intestinal epithelial Lgr5(hi) stem cells | 0.274177 | -1.86682 | 0.000682837446229767 | 0.00509995440499286 | DataSet_11_010 |
| Gjb2 | Batf2 | knockdown | Bone_marrow | Bone marrow-derived macrophages | 0.474571 | -1.0753 | 0.000201534954222528 | 0.00252025405852527 | DataSet_11_012 |
| Gjb2 | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 0.654856 | -0.61075 | 0.0864926349762037 | 0.461501736405059 | DataSet_11_013 |
| Gjb2 | Bcl6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.617721 | -0.694972 | 0.31850097681366 | 0.669677671695819 | DataSet_11_014 |
| Gjb2 | Bhlha9 | knockout | Limb | Whole limb bud | 3.05318 | 1.61031 | - | - | DataSet_11_016 |
| Gjb2 | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 0.477145 | -1.0675 | 0.328623172058405 | 0.999788745984441 | DataSet_11_020 |
| Gjb2 | Cebpb | shRNA | Mammary_gland | 4T1 mammary tumor cells | 0.203968 | -2.29359 | 0.196346285600617 | 0.999984070881864 | DataSet_11_022 |
| Gjb2 | Dmrt1 | knockout | Testis | Juvenile testes | 0.533275 | -0.907049 | 0.0518725825218067 | 0.53559692888952 | DataSet_11_025 |
| Gjb2 | Dmrt1 | knockout | Testis | Juvenile testes | 0.625488 | -0.676946 | 0.138297643412395 | 0.932139260123802 | DataSet_11_026 |
| Gjb2 | Dmrt1 | knockout | Testis | Juvenile testes | 0.609258 | -0.714875 | 0.0330066013180292 | 0.823523031933969 | DataSet_11_028 |
| Gjb2 | Dmrt1 | knockout | Testis | Testes | 2.09284 | 1.06546 | 0.000750624505523682 | 0.0318378381780505 | DataSet_11_029 |
| Gjb2 | Dmrt1 | knockout | Testis | Testes | 2.09284 | 1.06546 | 0.000750624505523682 | 0.0318378381780505 | DataSet_11_032 |
| Gjb2 | E2f4 | knockout | Brain | Forebrain | 3.70954 | 1.89124 | - | - | DataSet_11_033 |
| Gjb2 | Elf5 | knockout | Mammary_gland | Mammary gland | 0.320714 | -1.64064 | 0.0174761206488851 | 0.234913945805914 | DataSet_11_035 |
| Gjb2 | Foxp1 | knockout | Eye | Lens | 1.88172 | 0.912052 | - | - | DataSet_11_044 |
| Gjb2 | Gata2 | knockout | Kidney | renal collecting duct cells | 0.45355 | -1.14067 | - | - | DataSet_11_047 |
| Gjb2 | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 1.62519 | 0.70061 | 0.637363687038758 | 0.987135756219234 | DataSet_11_048 |
| Gjb2 | Gfi1b | knockout | Bone_marrow | Ter119 positive erythroid cells | 0.355492 | -1.49211 | - | - | DataSet_11_054 |
| Gjb2 | Hsf4 | knockout | Eye | Lens | 0.586935 | -0.768728 | 0.550394889191636 | 0.987999303842427 | DataSet_11_058 |
| Gjb2 | Irf6 | knockout | Skin | Skin | 4.91783 | 2.29802 | 7.90956579740578e-05 | 0.0133860304273488 | DataSet_11_062 |
| Gjb2 | Klf6 | shRNA | Liver | HCC | 2.13942 | 1.09722 | 0.160242044722778 | 0.998072688143085 | DataSet_11_067 |
| Gjb2 | Lhx8 | knockout | Gonads | Oocytes | 0.551692 | -0.858065 | 0.0741699219052373 | 0.993830266659981 | DataSet_11_069 |
| Gjb2 | Lhx8 | knockout | Ovary | Ovary | 0.515033 | -0.957264 | 0.0035572996947639 | 0.0297974109434699 | DataSet_11_070 |
| Gjb2 | Mafg | knockout | Embryo | Whole embryo | 0.385481 | -1.37527 | 0.102394943784102 | 1 | DataSet_11_073 |
| Gjb2 | Mbd2 | knockout | Lymph | GFP+ BM leukemia cells | 1.68009 | 0.748541 | 0.0207913583271521 | 0.100802609411749 | DataSet_11_076 |
| Gjb2 | Meis1 | knockout | Hematopoietic | KSL hematopoietic cells | 0.650646 | -0.620056 | 0.258000500012431 | 0.995635220774426 | DataSet_11_081 |
| Gjb2 | Neurod1 | knockout | Eye | Retina | 2.93802 | 1.55484 | 0.07794766822185 | 0.21615639210301 | DataSet_11_088 |
| Gjb2 | Nhlh2 | knockout | Eye | Retina | 0.625344 | -0.677277 | 0.829707342411252 | 0.87718496364386 | DataSet_11_092 |
| Gjb2 | Nr2f2 | knockout | Ovary | E16.5 Ovary | 0.468249 | -1.09465 | 0.154193508641077 | 0.547498836069219 | DataSet_11_095 |
| Gjb2 | Nrf1 | knockdown | Liver | Liver | 1.55564 | 0.637505 | 0.0162372478628133 | 0.0587597474157878 | DataSet_11_096 |
| Gjb2 | Otx2 | knockout | Eye | Retina | 2.23333 | 1.1592 | 0.401084464298829 | 0.999923528647439 | DataSet_11_097 |
| Gjb2 | p63 | siRNA | Skin | Primary keratinocytes | 0.471469 | -1.08477 | 0.000553296716431323 | 0.00712017724144772 | DataSet_11_099 |
| Gjb2 | Pitx2 | knockout | Eye | Cornea | 0.567439 | -0.817464 | 0.0670580730807296 | 0.385332751450575 | DataSet_11_103 |
| Gjb2 | Plagl2 | knockout | Intestine | Small intestine | 0.353098 | -1.50186 | 0.00289548412994655 | 0.0515515939752088 | DataSet_11_104 |
| Gjb2 | Pparg | siRNA | Adipose_tissue | Preadipocytes | 0.338948 | -1.56087 | 0.00590825488386766 | 0.149312233581824 | DataSet_11_105 |
| Gjb2 | Rest | knockout | Brain | Brain | 2.18814 | 1.12971 | 0.276256451877174 | 1 | DataSet_11_113 |
| Gjb2 | Sall1 | knockout | Kidney | Kidney | 0.409824 | -1.28692 | 0.0050927110857047 | 0.438884044784307 | DataSet_11_122 |
| Gjb2 | Shox2 | knockout | Heart | Right atria | 2.10211 | 1.07184 | - | - | DataSet_11_124 |
| Gjb2 | Smad4 | siRNA | Brain | bEnd3 | 14.2938 | 3.83732 | - | - | DataSet_11_127 |
| Gjb2 | Smad4 | knockout | Aorta | Aortic arteries | 11.0495 | 3.46591 | 0.030970711449947 | 0.271880715847203 | DataSet_11_128 |
| Gjb2 | Snai1 | knockout | Embryo | Embryoid body | 2.38765 | 1.25559 | - | - | DataSet_11_129 |
| Gjb2 | Sox10 | siRNA | Melanoma | B16F10 | 0.393407 | -1.3459 | 5.82220854906949e-05 | 0.00133880260569774 | DataSet_11_136 |
| Gjb2 | Sox11 | knockout | Eye | Retina | 4.33333 | 2.11548 | - | - | DataSet_11_137 |
| Gjb2 | Sox17 | siRNA | Embryo | NG4 | 0.660355 | -0.598687 | 0.0167125355411969 | 0.206453067099443 | DataSet_11_139 |
| Gjb2 | Sox2 | siRNA | Embryo | NG4 | 2.46444 | 1.30126 | 0.0331894829274075 | 0.203182722962621 | DataSet_11_141 |
| Gjb2 | Spdef | knockout | Stomach | Stomach | 0.265503 | -1.9132 | 0.0663013426329466 | 0.844378361113003 | DataSet_11_147 |
| Gjb2 | Srf | knockout | Brain | Denate gyrus of hippocampus | 0.658314 | -0.603152 | 0.0735071483205367 | 0.864574303440368 | DataSet_11_149 |
| Gjb2 | Stat4 | knockout | Lymph | Lamina propria lymphocytes | 0.574181 | -0.800422 | 0.413740787328071 | 0.924261066168849 | DataSet_11_152 |
| Gjb2 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 2.46279 | 1.30029 | 0.17797187566455 | 0.369057655784687 | DataSet_11_153 |
| Gjb2 | Vdr | knockout | Bone_marrow | Bone marrow-derived macrophages | 1.74034 | 0.799372 | 0.113562122611885 | 0.999827445128963 | DataSet_11_174 |
| Gjb2 | Yy1 | knockout | White_adipose_tissue | Subcutaneous white adipose tissue | 0.0304305 | -5.03834 | 0.237009756447162 | 0.723075633346863 | DataSet_11_184 |
| Gjb2 | Cpeb1 | siRNA | Neuron | Neuro-2a | 2.45194 | 1.29392 | - | - | DataSet_11_189 |
| Gjb2 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.194827 | -2.35973 | 1.158202e-01 | 2.669531e-01 | DataSet_11_192 |
| Gjb2 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 0.237054 | -2.07671 | - | - | DataSet_11_196 |
| Gjb2 | Tet1 | knockout | Hippocampus | Hippocampus | 0.388525 | -1.36392 | 1.180392e-03 | 0.20631411 | DataSet_11_219 |
| Gjb2 | Ezh2 | knockdown | Brain | Brain | 0.456395 | -1.13164 | 1.657769e-02 | 0.1328150983 | DataSet_11_221 |
| Gjb2 | Brca1 | knockout | Brain | mouse P7 brain | 1.53585 | 0.619035 | 7.588135e-02 | 0.50168694 | DataSet_11_201 |
| Gjb2 | Brca1 | knockout | Brain | mouse P7 cortex | 1.96096 | 0.971558 | 8.272750e-05 | 7.390694e-03 | DataSet_11_203 |
| Gjb2 | Smarca4 | shRNA | Embryo | ES cells | 1.73298 | 0.793257 | - | - | DataSet_11_224 |
| Gjb2 | Smarca4 | shRNA | Embryo | ES cells | 1.73298 | 0.793257 | - | - | DataSet_11_225 |
| Gjb2 | Dux | siRNA | Embryo | ES cells | 0.571429 | -0.807355 | 1.531770e-01 | 0.8774371149 | DataSet_11_239 |
| Gjb2 | Ncl | siRNA | Embryo | ES cells | 0.253968 | -1.97728 | 1.824031e-02 | 0.2779040128 | DataSet_11_240 |
| Gjb2 | Dnmt3b | siRNA | Embryo | iPSC | 0.588837 | -0.764061 | - | - | DataSet_11_242 |
| Gjb2 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 0.306196 | -1.70747 | 6.728161e-03 | 0.0791523905 | DataSet_11_245 |
| Gjb2 | Ezh2 | knockout | Calvaria | calvaria | 0.626866 | -0.673772 | 9.935983e-02 | 0.47979348 | DataSet_11_247 |
| Gjb2 | Kdm2a | CRISPR | Embryo | ES cells | 0.333333 | -1.58496 | 0.2836771289 | 1.0000000 | DataSet_11_251 |
| Gjb2 | Eed | knockout | Brain | Forebrain | 3.20059 | 1.67834 | 2.224741e-01 | 7.188597e-01 | DataSet_11_258 |
| Gjb2 | Eed | knockout | Brain | hindbrain | 3.62318 | 1.85726 | 2.453781e-02 | 5.750103e-01 | DataSet_11_259 |
| Gjb2 | Eed | knockout | Brain | midbrain | 2.8924 | 1.53227 | 2.270123e-01 | 9.620062e-01 | DataSet_11_260 |
| Gjb2 | Bcl3 | knockout | Bone | Osteoblast | 0.304563 | -1.71519 | 5.380752e-04 | 1.846538e-01 | DataSet_11_263 |
| Gjb2 | Dux | knockout | Embryo | Embryo | 8.20469 | 3.03645 | 2.070976e-04 | 1.972197e-03 | DataSet_11_269 |
| Gjb2 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 20.1218 | 4.33069 | 3.903218e-01 | 0.81420760 | DataSet_11_272 |
| Gjb2 | Dux | knockout | Embryo | Embryo | 8.20469 | 3.03645 | 2.070968e-04 | 1.971997e-03 | DataSet_11_273 |
| Gjb2 | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 0.470588 | -1.08746 | 9.139933e-01 | 9.673643e-01 | DataSet_11_276 |
| Gjb2 | Usp7 | knockout | Embryo | ES cells | 0.333333 | -1.58496 | 3.789195e-01 | 0.6514694 | DataSet_11_279 |
| Gjb2 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 2.2379 | 1.16215 | 3.494677e-02 | 0.5395938 | DataSet_11_284 |
| Gjb2 | Usp7 | siRNA | Embryo | ES cells | 2.5 | 1.32193 | 4.651055e-01 | 0.7347604 | DataSet_11_287 |
| Gjb2 | Fli1 | CRISPR | Lymph | CD8 T cells | 1.84286 | 0.881944 | 9.955372e-01 | 0.9999740103 | DataSet_11_288 |
| Gjb2 | Ssrp1 | CRISPR | Embryo | ES cells | 0.615385 | -0.70044 | 7.661815e-02 | 0.33042941 | DataSet_11_296 |
| Gjb2 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.574553 | -0.799487 | - | - | DataSet_11_305 |
| Gjb2 | Suz12 | knockout | Lung | Alveolar macrophage | 72 | 6.16993 | 4.612548e-02 | 0.3294220763 | DataSet_11_311 |
| Gjb2 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.153846 | -2.70044 | - | - | DataSet_11_313 |
| Gjb2 | Satb2 | knockout | Colon | Intestine epithelium | 1.6375 | 0.711495 | 4.541806e-02 | 0.3366110029 | DataSet_11_316 |
| Gjb2 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.652158 | -0.616706 | 1.474662e-01 | 3.488354e-01 | DataSet_11_320 |
| Gjb2 | Bud31 | knockout | Testis | Spermatogonial stem cells | 8.90909 | 3.15528 | 2.461203e-01 | 0.8600602 | DataSet_11_321 |
| Gjb2 | Gata2 | knockout | Brain | Pituitary gland | 0.288889 | -1.79141 | 0.169200572 | 0.9730581 | DataSet_11_322 |
| Gjb2 | Setdb1 | shRNA | Neuron | NE-4C | 0.131691 | -2.92477 | - | - | DataSet_11_323 |
| Gjb2 | Prmt1 | siRNA | Adipose_tissue | 3T3-L1 cells | 0.5 | -1 | 7.548197e-01 | 0.9832045 | DataSet_11_325 |
| Gjb2 | Snai1 | knockdown | Heart | Heart | 0.346201 | -1.53032 | 2.739606e-01 | 0.48947880 | DataSet_11_326 |
| Gjb2 | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 3.68317 | 1.88095 | 2.048063e-01 | 0.9609895 | DataSet_11_327 |
| Gjb2 | Atrx | knockout | Embryo | ES cells | 0.5 | -1 | - | - | DataSet_11_335 |
| Gjb2 | Dnmt3a | siRNA | Heart | embryonic cardiomyocytes | 0.153846 | -2.70044 | 7.472875e-03 | 0.27218870 | DataSet_11_337 |
| Gjb2 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.384615 | -1.37851 | 5.665785e-02 | 0.115943196 | DataSet_11_340 |
| Gjb2 | Hnrnpk | siRNA | Embryo | ES cells | 0.429833 | -1.21815 | 7.620479e-03 | 0.022645581 | DataSet_11_342 |
| Gjb2 | Pcbp1 | shRNA | Thymus | Th1 | 2.2 | 1.1375 | 1.636119e-01 | 0.44012353 | DataSet_11_343 |
Regulation Region
Expression Atlas of Gjb2